2024 ICD-10-CM Diagnosis Code T45.0X5D

Adverse effect of antiallergic and antiemetic drugs, subsequent encounter

ICD-10-CM Code:
T45.0X5D
ICD-10 Code for:
Adverse effect of antiallergic and antiemetic drugs, subs
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified
        (T45)

T45.0X5D is a billable diagnosis code used to specify a medical diagnosis of adverse effect of antiallergic and antiemetic drugs, subsequent encounter. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

T45.0X5D is a subsequent encounter code, includes a 7th character and should be used after the patient has completed active treatment for a condition like adverse effect of antiallergic and antiemetic drugs. According to ICD-10-CM Guidelines a "subsequent encounter" occurs when the patient is receiving routine care for the condition during the healing or recovery phase of treatment. Subsequent diagnosis codes are appropriate during the recovery phase, no matter how many times the patient has seen the provider for this condition. If the provider needs to adjust the patient's care plan due to a setback or other complication, the encounter becomes active again.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • 5-HT3-receptor antagonist adverse reaction
  • Acrivastine adverse reaction
  • Adverse reaction to antihistamines
  • Adverse reaction to mast cell stabilizer
  • Adverse reaction to meclizine
  • Adverse reaction to xanthine and/or xanthine derivative
  • Antazoline adverse reaction
  • Antiemetic adverse reaction
  • Astemizole adverse reaction
  • Azatadine adverse reaction
  • Azelastine adverse reaction
  • Brompheniramine adverse reaction
  • Cetirizine adverse reaction
  • Chlorphenamine adverse reaction
  • Cinnarizine adverse reaction
  • Clemastine adverse reaction
  • Cough suppressant adverse reaction
  • Cyclizine adverse reaction
  • Cyproheptadine adverse reaction
  • Dimenhydrinate adverse reaction
  • Dimethindene adverse reaction
  • Diphenhydramine adverse reaction
  • Diphenylpyraline adverse reaction
  • Domperidone adverse reaction
  • H1 antihistamine adverse reaction
  • Ketotifen adverse reaction
  • Lodoxamide adverse reaction
  • Loratadine adverse reaction
  • Mebhydrolin adverse reaction
  • Mepyramine adverse reaction
  • Metoclopramide adverse reaction
  • Oxatomide adverse reaction
  • Phenindamine adverse reaction
  • Pheniramine adverse reaction
  • Terfenadine adverse reaction
  • Triprolidine adverse reaction

Clinical Classification

Clinical Information

  • Astemizole

    antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
  • Brompheniramine

    histamine h1 antagonist used in treatment of allergies, rhinitis, and urticaria.
  • Cetirizine

    a potent second-generation histamine h1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
  • Chlorpheniramine

    a histamine h1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. it has also been used in veterinary applications. one of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
  • Cinnarizine

    a piperazine derivative having histamine h1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces parkinsonian disorders.
  • Clemastine

    a histamine h1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. it causes drowsiness.
  • Cyclizine

    a histamine h1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (from martindale, the extra pharmacopoeia, 30th ed, p935)
  • Cyproheptadine

    a serotonin antagonist and a histamine h1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
  • Dimenhydrinate

    a drug combination that contains diphenhydramine and theophylline. it is used for treating vertigo, motion sickness, and nausea associated with pregnancy.
  • Dimethindene

    a histamine h1 antagonist. it is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
  • Diphenhydramine

    a histamine h1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. it has some undesired antimuscarinic and sedative effects.
  • Domperidone

    a specific blocker of dopamine receptors. it speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
  • Doxylamine

    histamine h1 antagonist with pronounced sedative properties. it is used in allergies and as an antitussive, antiemetic, and hypnotic. doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
  • Granisetron

    a serotonin receptor (5ht-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
  • Ketotifen

    a cycloheptathiophene blocker of histamine h1 receptors and release of inflammatory mediators. it has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
  • Methapyrilene

    histamine h1 antagonist with sedative action used as a hypnotic and in allergies.
  • Metoclopramide

    a dopamine d2 antagonist that is used as an antiemetic.
  • Ondansetron

    a competitive serotonin type 3 receptor antagonist. it is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
  • Pheniramine

    one of the histamine h1 antagonists with little sedative action. it is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
  • Pyrilamine

    a histamine h1 antagonist. it has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. it is a common ingredient of cold remedies.
  • Terfenadine

    a selective histamine h1-receptor antagonist devoid of central nervous system depressant activity. the drug was used for allergy but withdrawn due to causing long qt syndrome.
  • Tripelennamine

    a histamine h1 antagonist with low sedative action but frequent gastrointestinal irritation. it is used to treat asthma; hay fever; urticaria; and rhinitis; and also in veterinary applications. tripelennamine is administered by various routes, including topically.
  • Triprolidine

    histamine h1 antagonist used in allergic rhinitis; asthma; and urticaria. it is a component of cough and cold medicines. it may cause drowsiness.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (T45). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10-CM Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)

T45.0X5D is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA IndicatorReason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert T45.0X5D to ICD-9-CM

  • ICD-9-CM Code: V58.89 - Other specfied aftercare
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Table of Drugs and Chemicals

The parent code T45.0X5 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AcrivastineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
AlizaprideT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Antazolin (e)T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Antiallergic NECT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Antiemetic drugT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
AntihistamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Antinausea drugT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
AntistineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Antivertigo drugT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
AstemizoleT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
AzatadineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
AzelastineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BamipineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BenadrylT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Benzhydramine (chloride)T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BenzquinamideT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Bisulepin (hydrochloride)T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BonineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BromazineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BromodiphenhydramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BrompheniramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
BuclizineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
CarbinoxamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Cerium oxalateT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Cerous oxalateT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
CetirizineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
CetoximeT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ChlorcyclizineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ChloropyramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ChloropyrileneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ChlorothenT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ChlorphenamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ChlorpheniramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ChlorphenoxamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Chlor-TrimetonT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
CinnarizineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ClemastineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ClemizoleT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Clemizole
  »penicillin
T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ClorfenamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
CyclizineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
CyproheptadineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DeptropineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DexbrompheniramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DexchlorpheniramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DibenzheptropineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DifenidolT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DimenhydrinateT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DimetaneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DimethindeneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DimetindeneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DiphenhydramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DiphenidolT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DiphenylpyralineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DomperidoneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DoxylamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
DramamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
EmbramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
GranisetronT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
HomochlorcyclizineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
IsothipendylT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
KetotifenT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Levocabastine (hydrochloride)T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
LoratidineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MarezineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MebhydrolinT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Meclizine (hydrochloride)T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MeclozineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MephenhydramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MepyramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MethaphenileneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MethapyrileneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MetoclopramideT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
MoxastineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
NytolT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
OndansetronT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
OxatomideT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Percogesic [See Also: acetaminophen]T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PeriactinT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PhenindamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PheniramineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PhenyltoloxamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PimethixeneT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PipamazineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PipoxizineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PiprinhydrinateT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PropiomazineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PyrathiazineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PyribenzamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PyrilamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
PyrrobutamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
RotoxamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
SetastineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Sleep-ezeT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
SominexT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TerfenadineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
ThenyldiamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Thonzylamine (systemic)T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
Thonzylamine (systemic)
  »mucosal decongestant
T45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TiganT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TranilastT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TrimethobenzamideT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TrimetonT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TripelennamineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TriprolidineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6
TritoqualineT45.0X1T45.0X2T45.0X3T45.0X4T45.0X5T45.0X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.