2024 ICD-10-CM Diagnosis Code T45.615
Adverse effect of thrombolytic drugs
- ICD-10-CM Code:
- T45.615
- ICD-10 Code for:
- Adverse effect of thrombolytic drugs
- Is Billable?
- Not Valid for Submission
- Code Navigator:
T45.615 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of thrombolytic drugs. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.
Specific Coding Applicable to Adverse effect of thrombolytic drugs
Non-specific codes like T45.615 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of thrombolytic drugs:
Approximate Synonyms
The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:
- Adverse reaction to fibrinolytic drugs
- Alteplase adverse reaction
- Anistreplase adverse reaction
- Drug-induced fibrinolytic disorder
- Fibrinolytic disorder caused by tissue plasminogen activator
- Fibrinolytic disorder caused by urokinase
- Hemorrhage after administration of thrombolytic agent
- Intracranial hemorrhage following administration of thrombolytic agent
- Streptokinase adverse reaction
- Streptokinase streptodornase adverse reaction
- Urokinase adverse reaction
Clinical Information
Anistreplase
an acylated inactive complex of streptokinase and human lysine-plasminogen. after injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. its half-life is about 90 minutes compared to 5 minutes for tpa; (tissue plasminogen activator); 16 minutes for urokinase-type plasminogen activator and 23 minutes for streptokinase. if treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. bleeding complications are similar to other thrombolytic agents.Streptodornase and Streptokinase
a mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. it is used topically on surface lesions and by instillation in closed body cavities to remove clotted blood or fibrinous or purulent accumulations. it is also used as a skin test antigen in evaluating generalized cell-mediated immunodeficiency. (dorland, 27th ed) ec 3.-.Streptokinase
streptococcal fibrinolysin . an enzyme produced by hemolytic streptococci. it hydrolyzes amide linkages and serves as an activator of plasminogen. it is used in thrombolytic therapy and is used also in mixtures with streptodornase (streptodornase and streptokinase). ec 3.4.-.
Coding Guidelines
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (T45). Use the following options for the aplicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Table of Drugs and Chemicals
The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.
According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.
Substance | Poisoning Accidental (unintentional) |
Poisoning Accidental (self-harm) |
Poisoning Assault |
Poisoning Undetermined |
Adverse effect |
Underdosing |
---|---|---|---|---|---|---|
Alteplase | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Anistreplase | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Fibrinolytic drug | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Plasminogen (tissue) activator | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Rt-PA | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Streptokinase | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Thrombolysin | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Urokinase | T45.611 | T45.612 | T45.613 | T45.614 | T45.615 | T45.616 |
Patient Education
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
What is a drug interaction?
A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:
- Two drugs, such as aspirin and blood thinners
- Drugs and food, such as statins and grapefruit
- Drugs and supplements, such as gingko and blood thinners
- Drugs and medical conditions, such as aspirin and peptic ulcers
Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.
What are side effects?
Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.
What are drug allergies?
Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.
How can I stay safe when taking medicines?
When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.
[Learn More in MedlinePlus]
Code History
- FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
- FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
- FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
- FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
- FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
- FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
- FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
- FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
- FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.