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  6. 2026 ICD-10-CM Code T45

2026 ICD-10-CM Diagnosis Code T45

Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified

ICD-10-CM Code:
T45
ICD-10 Code for:
Primarily systemic and hematological agents, NEC
Is Billable?
Not Valid for Submission
Code Navigator:

T45 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified. The code is not specific and is NOT valid for the year 2026 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Primarily systemic and hematological agents, NEC

Non-specific codes like T45 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for primarily systemic and hematological agents, nec:

  • T45.0 for Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs - NON-BILLABLE CODE

  • T45.0X for Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs - NON-BILLABLE CODE

  • T45.1 for Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs - NON-BILLABLE CODE

  • T45.1X for Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs - NON-BILLABLE CODE

  • T45.2 for Poisoning by, adverse effect of and underdosing of vitamins - NON-BILLABLE CODE

  • T45.2X for Poisoning by, adverse effect of and underdosing of vitamins - NON-BILLABLE CODE

  • T45.3 for Poisoning by, adverse effect of and underdosing of enzymes - NON-BILLABLE CODE

  • T45.3X for Poisoning by, adverse effect of and underdosing of enzymes - NON-BILLABLE CODE

  • T45.4 for Poisoning by, adverse effect of and underdosing of iron and its compounds - NON-BILLABLE CODE

  • T45.4X for Poisoning by, adverse effect of and underdosing of iron and its compounds - NON-BILLABLE CODE

  • T45.5 for Poisoning by, adverse effect of and underdosing of anticoagulants and antithrombotic drugs - NON-BILLABLE CODE

  • T45.51 for Poisoning by, adverse effect of and underdosing of anticoagulants - NON-BILLABLE CODE

  • T45.52 for Poisoning by, adverse effect of and underdosing of antithrombotic drugs - NON-BILLABLE CODE

  • T45.6 for Poisoning by, adverse effect of and underdosing of fibrinolysis-affecting drugs - NON-BILLABLE CODE

  • T45.60 for Poisoning by, adverse effect of and underdosing of unspecified fibrinolysis-affecting drugs - NON-BILLABLE CODE

  • T45.61 for Poisoning by, adverse effect of and underdosing of thrombolytic drugs - NON-BILLABLE CODE

  • T45.62 for Poisoning by, adverse effect of and underdosing of hemostatic drugs - NON-BILLABLE CODE

  • T45.69 for Poisoning by, adverse effect of and underdosing of other fibrinolysis-affecting drugs - NON-BILLABLE CODE

  • T45.7 for Poisoning by, adverse effect of and underdosing of anticoagulant antagonists, vitamin K and other coagulants - NON-BILLABLE CODE

  • T45.7X for Poisoning by, adverse effect of and underdosing of anticoagulant antagonists, vitamin K and other coagulants - NON-BILLABLE CODE

  • T45.8 for Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents - NON-BILLABLE CODE

  • T45.8X for Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents - NON-BILLABLE CODE

  • T45.9 for Poisoning by, adverse effect of and underdosing of unspecified primarily systemic and hematological agent - NON-BILLABLE CODE

  • T45.91 for Poisoning by unspecified primarily systemic and hematological agent, accidental (unintentional) - NON-BILLABLE CODE

  • T45.92 for Poisoning by unspecified primarily systemic and hematological agent, intentional self-harm - NON-BILLABLE CODE

  • T45.93 for Poisoning by unspecified primarily systemic and hematological agent, assault - NON-BILLABLE CODE

  • T45.94 for Poisoning by unspecified primarily systemic and hematological agent, undetermined - NON-BILLABLE CODE

  • T45.95 for Adverse effect of unspecified primarily systemic and hematological agent - NON-BILLABLE CODE

  • T45.96 for Underdosing of unspecified primarily systemic and hematological agent - NON-BILLABLE CODE

  • T45.A for Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs - NON-BILLABLE CODE

  • T45.AX for Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs - NON-BILLABLE CODE

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    S00–T88
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      T36-T50
      • Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified
        T45

Coding Guidelines

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (T45). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


7th Character Note

7th Character Note
Certain ICD-10-CM categories have applicable 7th characters. The applicable 7th character is required for all codes within the category, or as the notes in the Tabular List instruct. The 7th character must always be the 7th character in the data field. If a code that requires a 7th character is not 6 characters, a placeholder X must be used to fill in the empty characters.
  • The appropriate 7th character is to be added to each code from category T45

7th Character

7th Character
Indicates that a seventh character is to be assigned to codes in a subcategory.
  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Code History

  • FY 2026 - No Change, effective from 10/1/2025 through 9/30/2026
  • FY 2025 - No Change, effective from 10/1/2024 through 9/30/2025
  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.