ICD-10 Code T45.1X5A

Adverse effect of antineoplastic and immunosuppressive drugs, initial encounter

Version 2019 Replaced Code Billable Code Unacceptable Principal Diagnosis
Short Description:Adverse effect of antineoplastic and immunosup drugs, init
Long Description:Adverse effect of antineoplastic and immunosuppressive drugs, initial encounter

Valid for Submission

ICD-10 T45.1X5A is a billable code used to specify a medical diagnosis of adverse effect of antineoplastic and immunosuppressive drugs, initial encounter. The code is valid for the year 2019 for the submission of HIPAA-covered transactions.

Deleted Code

This code was deleted in the 2019 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2018. This code was replaced for the FY 2019 (October 1, 2018 - September 30, 2019).

  • K59.03 - Drug induced constipation

Code Classification

  • Injury, poisoning and certain other consequences of external causes (S00–T98)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50)
      • Primarily systemic and hematological agents, NEC (T45)

Information for Medical Professionals

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10 Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual’s health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Convert T45.1X5A to ICD-9

The following crosswalk between ICD-10 to ICD-9 is based based on the General Equivalence Mappings (GEMS) information:

  • 995.29 - Adv eff med/biol NEC/NOS (Combination Flag)
  • E933.1 - Adv eff antineoplastic (Combination Flag)


The following clinical terms are approximate synonyms:

  • Accelerated rheumatoid nodulosis
  • Accelerated rheumatoid nodulosis due to methotrexate
  • Aclarubicin adverse reaction
  • Acral erythema
  • Acral erythema due to cytotoxic therapy
  • Adverse reaction to antineoplastic antibiotics
  • Adverse reaction to drug or medicament administered by infusion
  • Adverse reaction to drug or medicament administered by infusion
  • Adverse reaction to rituximab administered by infusion
  • Adverse reaction to trastuzumab administered by infusion
  • Aldesleukin adverse reaction
  • Alkylating drug adverse reaction
  • Amifostine adverse reaction
  • Amsacrine adverse reaction
  • Antimetabolite adverse reaction
  • Antineoplastic adverse reaction
  • Aplastic anemia caused by antineoplastic agent
  • Aplastic anemia due to drugs
  • Azathioprine adverse reaction
  • Azoospermia
  • Azoospermia caused by chemotherapy
  • Bleomycin adverse reaction
  • Busulfan adverse reaction
  • Carboplatin adverse reaction
  • Carmustine adverse reaction
  • Cellular atypia due to antineoplastic agent
  • Chemotherapy-induced nausea and vomiting
  • Chemotherapy-induced neutropenia
  • Chemotherapy-induced peripheral neuropathy
  • Chlorambucil adverse reaction
  • Chlormethine adverse reaction
  • Chronic cyclosporin A nephrotoxicity
  • Chronic drug-induced renal disease
  • Chronic drug-induced renal disease
  • Chronic drug-induced renal disease
  • Cirrhosis of liver caused by methotrexate
  • Cisplatin adverse reaction
  • Cis-platinum nephropathy
  • Complication of chemotherapy
  • Complication of chemotherapy
  • Complication of chemotherapy
  • Crisantaspase adverse reaction
  • Cutaneous ulceration due to cytotoxic therapy
  • Cyclophosphamide adverse reaction
  • Cyclosporin adverse reaction
  • Cytarabine adverse reaction
  • Cytotoxic antibiotic adverse reaction
  • Dacarbazine adverse reaction
  • Dactinomycin adverse reaction
  • Dermatosis resulting from immunosuppressive therapy
  • Dimethyl sulfoxide adverse reaction
  • Doxorubicin adverse reaction
  • Drug-induced cirrhosis of liver
  • Drug-induced neutropenia
  • Epirubicin adverse reaction
  • Esophagitis due to chemotherapy
  • Esophagitis medicamentosa
  • Estramustine adverse reaction
  • Ethoglucid adverse reaction
  • Etoposide adverse reaction
  • Fatigue due to chemotherapy or radiation therapy
  • Fatigue due to treatment
  • Fludarabine adverse reaction
  • Fluorouracil adverse reaction
  • Gonad regulating hormone adverse reaction
  • Gonad regulating hormone adverse reaction
  • Gonad regulating hormone adverse reaction
  • Goserelin adverse reaction
  • Hydroxycarbamide adverse reaction
  • Idarubicin adverse reaction
  • Ifosfamide adverse reaction
  • Immunodeficiency secondary to chemotherapy
  • Immunosuppressant adverse reaction
  • Leuprorelin adverse reaction
  • Lomustine adverse reaction
  • Malignant neoplasm after immunosuppressive therapy
  • Melphalan adverse reaction
  • Mercaptopurine adverse reaction
  • Methotrexate adverse reaction
  • Methotrexate poisoning
  • Methotrexate skin ulceration
  • Methyl CCNU nephropathy
  • Mitobronitol adverse reaction
  • Mitomycin adverse reaction
  • Mitoxantrone adverse reaction
  • Mucositis following chemotherapy
  • Mucositis following therapy
  • Nausea and vomiting
  • Nephropathy induced by cyclosporine
  • Nephropathy induced by tacrolimus
  • Neurotoxicity
  • Neurotoxicity
  • Neurotoxicity
  • Neurotoxicity
  • Neurotoxicity
  • Neurotoxicity due to L-asparaginase
  • Neurotoxicity due to methotrexate
  • Neurotoxicity due to procarbazine
  • Neurotoxicity due to vinblastine
  • Neurotoxicity due to vincristine
  • Nitrogen mustard derivative adverse reaction
  • Nitrosurea adverse reaction
  • Oral ulcerative mucositis due to antineoplastic therapy
  • Paclitaxel adverse reaction
  • Pentostatin adverse reaction
  • Plicamycin adverse reaction
  • Poisoning by L-asparaginase
  • Procarbazine adverse reaction
  • Procarbazine poisoning
  • Razoxane adverse reaction
  • Retinoid adverse reaction
  • Rheumatoid nodulosis
  • Secondary aplastic anemia
  • Stomatitis due to cytotoxic therapy
  • Stomatitis medicamentosa
  • Stomatitis medicamentosa
  • Subcutaneous rheumatoid nodule
  • Terpenes adverse reaction
  • Terpenes adverse reaction
  • Thioguanine adverse reaction
  • Thiotepa adverse reaction
  • Thrombophilia due to antineoplastic agent therapy
  • Thrombophilia due to drug therapy
  • Treosulfan adverse reaction
  • Triazene antineoplastic adverse reaction
  • Triptorelin adverse reaction
  • Ulcerative stomatitis
  • Vinblastine adverse reaction
  • Vinblastine poisoning
  • Vinca alkaloid adverse reaction
  • Vincristine adverse reaction
  • Vincristine poisoning
  • Vindesine adverse reaction

Information for Patients

Drug Reactions

Also called: Side effects

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

  • Angioedema (Medical Encyclopedia)
  • Drug allergies (Medical Encyclopedia)
  • Drug-induced diarrhea (Medical Encyclopedia)
  • Drug-induced tremor (Medical Encyclopedia)
  • Taking multiple medicines safely (Medical Encyclopedia)

[Read More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.