2024 ICD-10-CM Diagnosis Code T44.995

Adverse effect of other drug primarily affecting the autonomic nervous system

ICD-10-CM Code:
T44.995
ICD-10 Code for:
Adverse effect of drug aff the autonomic nervous system
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system
        (T44)

T44.995 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of other drug primarily affecting the autonomic nervous system. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Adverse effect of drug aff the autonomic nervous system

Non-specific codes like T44.995 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of drug aff the autonomic nervous system:

  • Use T44.995A for initial encounter - BILLABLE CODE

  • Use T44.995D for subsequent encounter - BILLABLE CODE

  • Use T44.995S for sequela - BILLABLE CODE

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adverse reaction caused by decongestant
  • Adverse reaction caused by decongestant
  • Adverse reaction to dopamine receptor agonist
  • Adverse reaction to phenylpropanolamine
  • Dopamine adverse reaction
  • Ephedrine adverse reaction
  • Pseudoephedrine adverse reaction
  • Vasopressor adverse reaction

Clinical Information

  • Arylsulfotransferase

    a sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. a number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. ec 2.8.2.1.
  • Dopamine

    one of the catecholamine neurotransmitters in the brain. it is derived from tyrosine and is the precursor to norepinephrine and epinephrine. dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. a family of receptors (receptors, dopamine) mediate its action.
  • Dopamine Agents

    any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
  • Dopamine Agonists

    drugs that bind to and activate dopamine receptors.
  • Dopamine and cAMP-Regulated Phosphoprotein 32

    a phosphoprotein that was initially identified as a major target of dopamine activated adenylyl cyclase in the corpus striatum. it regulates the activities of protein phosphatase-1 and protein kinase a, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of dopamine.
  • Dopamine Antagonists

    drugs that bind to but do not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. many drugs used in the treatment of psychotic disorders (antipsychotic agents) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. dopamine antagonists have been used for several other clinical purposes including as antiemetics, in the treatment of tourette syndrome, and for hiccup. dopamine receptor blockade is associated with neuroleptic malignant syndrome.
  • Dopamine beta-Hydroxylase

  • Dopamine D2 Receptor Antagonists

    compounds and drugs that bind to and inhibit or block the activation of dopamine d2 receptors.
  • Dopamine Plasma Membrane Transport Proteins

    sodium chloride-dependent neurotransmitter symporters located primarily on the plasma membrane of dopaminergic neurons. they remove dopamine from the extracellular space by high affinity reuptake into presynaptic terminals and are the target of dopamine uptake inhibitors.
  • Dopamine Uptake Inhibitors

    drugs that block the transport of dopamine into axon terminals or into storage vesicles within terminals. most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
  • Dopaminergic Imaging

    functional brain imaging techniques that utilize various radionuclide tracers that bind to different targets in the synapses of dopaminergic neurons.
  • Dopaminergic Neurons

    neurons whose primary neurotransmitter is dopamine.
  • Receptors, Dopamine

    cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.
  • Receptors, Dopamine D1

    a subfamily of g-protein-coupled receptors that bind the neurotransmitter dopamine and modulate its effects. d1-class receptor genes lack introns, and the receptors stimulate adenylyl cyclases.
  • Receptors, Dopamine D2

    a subfamily of g-protein-coupled receptors that bind the neurotransmitter dopamine and modulate its effects. d2-class receptor genes contain introns, and the receptors inhibit adenylyl cyclases.
  • Receptors, Dopamine D3

    a subtype of dopamine d2 receptors that are highly expressed in the limbic system of the brain.
  • Receptors, Dopamine D4

    a subtype of dopamine d2 receptors that has high affinity for the antipsychotic clozapine.
  • Receptors, Dopamine D5

    a subtype of dopamine d1 receptors that has higher affinity for dopamine and differentially couples to gtp-binding proteins.
  • Ephedra

    a plant genus of the family ephedraceae, order ephedrales, class gnetopsida, division gnetophyta.
  • Ephedra sinica

    a plant species of the family ephedraceae, order ephedrales, class gnetopsida, division gnetophyta. it is a source of ephedrine and other alkaloids.
  • Ephedrine

    a phenethylamine found in ephedra sinica. pseudoephedrine is an isomer. it is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. it has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. it has become less extensively used with the advent of more selective agonists.
  • Pseudoephedrine

    a phenethylamine that is an isomer of ephedrine which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
  • Mephentermine

    a sympathomimetic agent with specificity for alpha-1 adrenergic receptors. it is used to maintain blood pressure in hypotensive states such as following spinal anesthesia.
  • Phenylpropanolamine

    a sympathomimetic that acts mainly by causing release of norepinephrine but also has direct agonist activity at some adrenergic receptors. it is most commonly used as a nasal vasoconstrictor and an appetite depressant.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (T44). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
Amezinium metilsulfateT44.991T44.992T44.993T44.994T44.995T44.996
AngiotensinamideT44.991T44.992T44.993T44.994T44.995T44.996
BenzedrexT44.991T44.992T44.993T44.994T44.995T44.996
DopamineT44.991T44.992T44.993T44.994T44.995T44.996
EphedraT44.991T44.992T44.993T44.994T44.995T44.996
EphedrineT44.991T44.992T44.993T44.994T44.995T44.996
IbopamineT44.991T44.992T44.993T44.994T44.995T44.996
IsoephedrineT44.991T44.992T44.993T44.994T44.995T44.996
MephentermineT44.991T44.992T44.993T44.994T44.995T44.996
PhenylpropanolamineT44.991T44.992T44.993T44.994T44.995T44.996
PseudoephedrineT44.991T44.992T44.993T44.994T44.995T44.996

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.