2027 ICD-10-CM Diagnosis Code E83.825CD73 deficiency causing arterial calcification

ICD-10-CM Codes›E00–E89›E70-E88›E83

ICD-10-CM E83.825
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E83.825 is a billable ICD-10-CM diagnosis code for CD73 deficiency causing arterial calcification. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 299 through 301. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 4 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified circulatory disease and Other specified and unspecified nutritional and metabolic disorders.

E83.825 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.

Code Identity

ICD-10-CM Code
E83.825
Billable Status
Yes — Valid for Submission
Code Describes
CD73 deficiency causing arterial calcification
Short Description
CD73 deficiency causing arterial calcification
Same as the full description in the CMS dataset.
Parent Code
E83.82
Disorders of pyrophosphate metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE83Disorders of mineral metabolism
This CodeE83.825CD73 deficiency causing arterial calcification

Medicare Risk Adjustment (HCC)Billing

E83.825 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
no payment category in the model that pays 100% of MA risk scores
Prior Model (CMS-HCC V24)
Not mapped under V24
this diagnosis newly risk-adjusts under the V28 model
Other CMS Models
PACE (CMS-HCC V22): HCC 23 · ESRD (V21): HCC 23 · ESRD (V24): HCC 23
ESRD V21 weights: 0.013 dialysis, 0.234–0.359 functioning graft · ESRD V24 weights: 0.036 dialysis, 0.217–0.390 functioning graft
Part D (RxHCC)
RxHCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E83.825: its own notes plus those printed at E83, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E83 Disorders of mineral metabolism applies to 31 codes
  • dietary mineral deficiency (E58-E61)
  • parathyroid disorders (E20-E21)
  • vitamin D deficiency (E55.-)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E83.825, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming E83.825: they are not reported together with it, unless the two conditions are unrelated.

  • E61 Deficiency of other nutrient elements
    disorders of mineral metabolism (E83.-) names E83.-, which includes this code
  • R79.0 Abnormal level of blood mineral
    disorders of mineral metabolism (E83.-) names E83.-, which includes this code

Excludes2 4

These codes carry an Excludes2 note naming E83.825: its condition is not part of those codes, and both may be reported when the patient has both.

  • E83.3 Disorders of phosphorus metabolism and phosphatases
    disorders of pyrophosphate metabolism (E83.82-) names E83.82-, which includes this code
  • I70.9 Other and unspecified atherosclerosis
    disorders of pyrophosphate metabolism (E83.82-) names E83.82-, which includes this code
  • Q28.8 Other specified congenital malformations of circulatory system
    disorders of pyrophosphate metabolism (E83.82-) names E83.82-, which includes this code
  • Q82.8 Other specified congenital malformations of skin
    disorders of pyrophosphate metabolism (E83.82-) names E83.82-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR CIR032
Other specified and unspecified circulatory disease
Default principal diagnosis: inpatient No · outpatient No
CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Atherosclerosis

Atherosclerosis is a condition in which plaque builds up inside your arteries. Plaque is a sticky substance made up of cholesterol, fat, blood cells, calcium, and other substances found in the blood. Over time, plaque hardens and causes your arteries to narrow. That limits the flow of oxygen-rich blood to your body.

The full article covers:

  • What is atherosclerosis?
  • What causes atherosclerosis?
  • Who is more likely to develop atherosclerosis?
  • What are the symptoms of atherosclerosis?
  • What other problems can atherosclerosis cause?
  • How is atherosclerosis diagnosed?
  • What are the treatments for atherosclerosis?
  • Can atherosclerosis be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement E83.825 replaces the following previously assigned code(s):

  • E83.89 - Other disorders of mineral metabolism
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E83.825Overview

What is the ICD-10 code for CD73 deficiency causing arterial calcification?

The ICD-10-CM code for CD73 deficiency causing arterial calcification is E83.825 (sometimes written as E83825). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E83.825 (Disorders of pyrophosphate metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report CD73 deficiency causing arterial calcification on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E83.825 group to?

When CD73 deficiency causing arterial calcification is the principal diagnosis on an inpatient stay, it groups to MS-DRG 301, 300, 299, with relative weights from 0.7132 to 1.5840 depending on complications. Higher weights mean higher Medicare reimbursement.

Is E83.825 a CC or MCC?

CMS lists E83.825 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 4 closely related codes in its exclusion list.

Can E83.825 be reported with a code from E55?

Not as a rule. The Excludes1 note at E83, which applies to E83.825, lists "vitamin D deficiency (E55.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E83.825 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage: E83.825 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).