2026 ICD-10-CM Diagnosis Code E79.89Other specified disorders of purine and pyrimidine metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E79

ICD-10-CM E79.89
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E79.89 is a billable ICD-10-CM diagnosis code for other specified disorders of purine and pyrimidine metabolism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E79.89
Billable Status
Yes — Valid for Submission
Code Describes
Other specified disorders of purine and pyrimidine metabolism
Short Description
Oth disrd of purine and pyrimidine metabolism
Parent Code
E79.8
Other disorders of purine and pyrimidine metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE79Disorders of purine and pyrimidine metabolism
This CodeE79.89Other specified disorders of purine and pyrimidine metabolism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • 5-amino-4-imidazole carboxamide ribosiduria
  • Adenine phosphoribosyl transferase deficiency type I
  • Adenine phosphoribosyl transferase deficiency type II
  • Adenylosuccinate lyase deficiency
  • APRT deficiency, Japanese type
  • Beta-aminoisobutyric aciduria
  • Congenital anomaly of macula
  • Cytosine diphosphate choline phosphotransferase deficiency
  • Deficiency of 3'-nucleotidase
  • Deficiency of 5'-nucleotidase
  • Deficiency of adenine deaminase
  • Deficiency of allantoicase
  • Deficiency of allantoinase
  • Deficiency of AMP deaminase
  • Deficiency of AMP nucleosidase
  • Deficiency of AMP pyrophorylase
  • Deficiency of aspartate carbamoyltransferase
  • Deficiency of beta-ureidopropionase
  • Deficiency of cytidine deaminase
  • Deficiency of dihydrouracil dehydrogenase
  • Deficiency of DNA repair
  • Deficiency of glycine formiminotransferase
  • Deficiency of GMP synthase
  • Deficiency of homologous recombination deoxyribonucleic acid repair
  • Deficiency of phosphoribosylaminoimidazole carboxylase
  • Deficiency of phosphoribosylaminoimidazolecarboxamide formyltransferase
  • Deficiency of phosphoribosylaminoimidazole-succinocarboxamide synthase
  • Deficiency of phosphoribosylformylglycinamidine cyclo-ligase
  • Deficiency of phosphoribosylformylglycinamidine synthase
  • Deficiency of thymidine phosphorylase
  • Deficiency of trimetaphosphatase
  • Deficiency of uridine phosphorylase
  • Deficiency of xanthine oxidase
  • Dihydropyrimidinase deficiency
  • Dihydropyrimidine dehydrogenase deficiency
  • DNA repair
  • Hereditary orotic aciduria
  • Hereditary orotic aciduria, type 1
  • Hereditary orotic aciduria, type 2
  • Hyperuricuria
  • Hypouricemia
  • Inosine triphosphate pyrophosphohydrolase deficiency
  • NUDT15 deficiency
  • Orotic aciduria
  • Phosphoribosylpyrophosphate synthetase superactivity
  • Ribose-phosphate pyrophosphokinase overactivity
  • Secondary orotic aciduria
  • Uridine monophosphate hydrolase deficiency

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Aciduria
      • orotic (congenital) (hereditary) (pyrimidine deficiency)
    • Disorder(of)
      • metabolism NOS
        • purine
          • specified NEC
    • Disorder(of)
      • metabolism NOS
        • pyrimidine
          • specified NEC
    • Orotaciduria, oroticaciduria(congenital) (hereditary) (pyrimidine deficiency)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • DNA End-Joining Repair

    the repair of double-strand dna breaks by rejoining the broken ends of dna to each other directly.

  • DNA Repair

    the removal of dna lesions and/or restoration of intact dna strands without base pair mismatches, intrastrand or interstrand crosslinks, or discontinuities in the dna sugar-phosphate backbones.

  • DNA Repair Enzymes

    enzymes that are involved in the reconstruction of a continuous two-stranded dna molecule without mismatch from a molecule, which contained damaged regions.

  • DNA Repair-Deficiency Disorders

    disorders resulting from defective dna repair processes or the associated cellular responses to dna damage.

  • O(6)-Methylguanine-DNA Methyltransferase

    an enzyme that transfers methyl groups from o(6)-methylguanine, and other methylated moieties of dna, to a cysteine residue in itself, thus repairing alkylated dna in a single-step reaction. ec 2.1.1.63.

  • Rad52 DNA Repair and Recombination Protein

    a dna-binding protein that mediates dna repair of double strand breaks, and homologous recombination.

  • Recombinational DNA Repair

    repair of dna damage by exchange of dna between matching sequences, usually between the allelic dna (alleles) of sister chromatids.

  • Dihydropyrimidine Dehydrogenase Deficiency

    an autosomal recessive disorder affecting dihydropyrimidine dehydrogenase and causing familial pyrimidinemia. it is characterized by thymine-uraciluria in homozygous deficient patients. even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-fluorouracil-associated toxicity.

  • DNA

    a deoxyribonucleotide polymer that is the primary genetic material of all cells. eukaryotic and prokaryotic organisms normally contain dna in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. dna, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

  • Hereditary Orotic Aciduria

    an extremely rare autosomal recessive inherited disorder caused by mutations in the umps gene. it is characterized by deficiency of the activity of the pyrimidine pathway enzyme uridine 5'-monophosphate (ump) synthase. clinical manifestations include growth retardation, anemia, and increased excretion of orotic acid in the urine.

Code History & ChangesHistory

Replacement E79.89 replaces the following previously assigned code(s):

  • E79.8 - Other disorders of purine and pyrimidine metabolism
FY 2024AddedAdded to the ICD-10-CM code setEffective October 1, 2023.
FY 2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E79.89Overview

Is E79.89 (Other disorders of purine and pyrimidine metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other specified disorders of purine and pyrimidine metabolism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.