2027 ICD-10-CM Diagnosis Code E74.810Glucose transporter protein type 1 deficiency
ICD-10-CM Codes›E00–E89›E70-E88›E74
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
E74.810 is a billable ICD-10-CM diagnosis code for glucose transporter protein type 1 deficiency. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 55 closely related codes. Coders also document this condition as epilepsy due to glucose transporter protein type 1 deficiency syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
E74.810 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E74.810 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Epilepsy due to glucose transporter protein type 1 deficiency syndrome
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E74.810: its own notes plus those printed at E74, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- De Vivo syndrome
- Glucose transport defect, blood-brain barrier
- Glut1 deficiency
- GLUT1 deficiency syndrome 1, infantile onset
- GLUT1 deficiency syndrome 2, childhood onset
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E74.810, its category, or a range that includes it.
Excludes1 3
These codes carry an Excludes1 note naming E74.810: they are not reported together with it, unless the two conditions are unrelated.
- D55.2 Anemia due to disorders of glycolytic enzymesdisorders of glycolysis not associated with anemia (E74.81-) names E74.81-, which includes this code
- R79 Other abnormal findings of blood chemistry
- Block R80-R82 Abnormal findings on examination of urine, without diagnosis
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Glut1 E74.810
Syndrome See Also: Disease;
de Vivo syndrome E74.810
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Carbohydrate Metabolism Disorders
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code History & ChangesHistory
Replacement E74.810 replaces the following previously assigned code(s):
- E74.8 - Other specified disorders of carbohydrate metabolism
Questions About E74.810Overview
What is the ICD-10 code for glucose transporter protein type 1 deficiency?
The ICD-10-CM code for glucose transporter protein type 1 deficiency is E74.810 (sometimes written as E74810). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E74.810 (Disorders of glucose transport, not elsewhere classified) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report glucose transporter protein type 1 deficiency on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E74.810 group to?
When glucose transporter protein type 1 deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Is E74.810 a CC or MCC?
CMS lists E74.810 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 55 closely related codes in its exclusion list.
Can E74.810 be reported with E16.2?
Not as a rule. The Excludes1 note at E74, which applies to E74.810, lists "hypoglycemia NOS (E16.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E74.810 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E74.810 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
