2026 ICD-10-CM Diagnosis Code E72.89Other specified disorders of amino-acid metabolism
ICD-10-CM Codes›E00–E89›E70-E88›E72
- Billable — Valid for Submission
- Chronic Condition
E72.89 is a billable ICD-10-CM diagnosis code for other specified disorders of amino-acid metabolism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- 2-hydroxyglutaric aciduria
- 3-Phosphoglycerate dehydrogenase deficiency
- 3-phosphoglycerate dehydrogenase deficiency infantile form
- 3-phosphoglycerate dehydrogenase deficiency juvenile form
- 5-Oxoprolinase deficiency
- Alaninemia
- Alpha ketoadipic aciduria
- Aminoacidemia
- Camptodactyly of finger
- Camptodactyly taurinuria syndrome
- Combined D-2-hydroxyglutaric aciduria and L-2-hydroxyglutaric aciduria
- Congenital porphyria
- Deficiency of 3-hydroxyisobutyrate dehydrogenase
- Deficiency of 4-hydroxy-2-oxoglutarate aldolase
- Deficiency of acid-aminoacid ligase
- Deficiency of adenosylhomocysteinase
- Deficiency of alanine aminotransferase
- Deficiency of alanine dehydrogenase
- Deficiency of alanine-oxo-acid aminotransferase
- Deficiency of alanine-tRNA ligase
- Deficiency of aminoacylase 1
- Deficiency of aminoacyl-histidine dipeptidase
- Deficiency of aminoacyltransferase
- Deficiency of aminopeptidase
- Deficiency of aminotransferase
- Deficiency of ammonia-lyase
- Deficiency of asparaginase
- Deficiency of asparagine-oxo-acid aminotransferase
- Deficiency of aspartate 4-decarboxylase
- Deficiency of aspartate aminotransferase
- Deficiency of aspartate kinase
- Deficiency of betaine-aldehyde dehydrogenase
- Deficiency of betaine-homocysteine methyltransferase
- Deficiency of carboxy-lyase
- Deficiency of carboxypeptidase A
- Deficiency of carboxypeptidase B
- Deficiency of carnosinase
- Deficiency of choline dehydrogenase
- Deficiency of cysteamine dioxygenase
- Deficiency of cysteine aminotransferase
- Deficiency of cysteine carboxypeptidase
- Deficiency of cysteine proteinase
- Deficiency of cysteinyl-glycine dipeptidase
- Deficiency of cystine reductase
- Deficiency of D-amino-acid oxidase
- Deficiency of D-aspartate oxidase
- Deficiency of glutamate decarboxylase
- Deficiency of glutamate dehydrogenase
- Deficiency of glutamate-ammonia ligase
- Deficiency of glutaminase
- Deficiency of glutamine phenylacetyltransferase
- Deficiency of glutamine-fructose-6-phosphate aminotransferase
- Deficiency of glutamine-pyruvate aminotransferase
- Deficiency of glycine amidinotransferase
- Deficiency of glycine hydroxymethyltransferase
- Deficiency of guanidinoacetate kinase
- Deficiency of guanidinoacetate methyltransferase
- Deficiency of homoserine kinase
- Deficiency of hydrolase
- Deficiency of L-amino-acid oxidase
- Deficiency of L-serine ammonia-lyase
- Deficiency of malonate CoA-transferase
- Deficiency of N-methyl-L-amino-acid oxidase
- Deficiency of phosphoserine phosphatase
- Deficiency of pyrroline-5-carboxylate reductase
- Deficiency of serine carboxypeptidase
- Deficiency of serine-tRNA ligase
- Deficiency of threonine aldolase
- Deficiency of threonine dehydratase
- Deficiency of threonine-tRNA ligase
- Dibasic aminoaciduria
- Dicarboxylic aminoaciduria syndrome
- Disorder of beta alanine, carnosine AND/OR homocarnosine metabolism
- Disorder of beta and omega amino acid metabolism
- Disorder of creatine synthesis
- Disorder of gamma aminobutyric acid metabolism
- Disorder of glutamine metabolism
- Disorder of phenylalanine metabolism
- Disorder of proline AND/OR hydroxyproline metabolism
- Disorder of serine metabolism
- Disorder of tetrahydrobiopterin metabolism
- Disorder of the gamma-glutamyl cycle
- Disorder of threonine metabolism
- Erythropoietic protoporphyria
- Erythropoietic protoporphyria due to gain of function of erythroid-specific aminolevulinic acid synthase 2
- Ferrochelatase deficiency
- Gamma-glutamyl transpeptidase deficiency
- Glutamate-cysteine ligase deficiency
- Glutathione synthase deficiency with 5-oxoprolinuria
- Glutathione synthase deficiency without 5-oxoprolinuria
- Glutathione synthetase deficiency
- Glutathionemia
- Glycoprolinuria
- Hereditary camptodactyly
- Homocarnosinase deficiency
- Hyper-beta-alaninemia
- Hyper-beta-carnosinemia
- Hyperdicarboxylicaminoaciduria AND hyperprolinemia
- Hyperhydroxyprolinemia
- Hyperprolinemia
- Iminoacidopathy
- Inborn error of glutathione metabolism
- Inherited aminoaciduria
- Lysinuric protein intolerance
- Neonatal epileptic encephalopathy due to glutaminase deficiency
- Phosphoserine aminotransferase deficiency
- Pipecolic acidemia
- Prolinuria
- Serine biosynthesis pathway deficiency, infantile/juvenile form
- Spastic ataxia, dysarthria due to glutaminase deficiency
- SSADH deficiency
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Disorders of beta-amino-acid metabolism
- Disorders of gamma-glutamyl cycle
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Disorder (of) - See Also: Disease;
- metabolism - See: Disturbance, metabolism, amino-acid;
- specified NEC - E72.89
- beta-amino-acid metabolism - E72.89
- gamma-glutamyl cycle - E72.89
- metabolism NOS - E88.9
- amino-acid - E72.9
- other specified - E72.89
- beta-amino acid - E72.89
- gamma-glutamyl cycle - E72.89
- straight-chain - E72.89
- glutamine - E72.89
- serine - E72.89
- threonine - E72.89
- Disturbance (s) - See Also: Disease;
- metabolism - E88.9
- amino-acid - E72.9
- straight-chain - E72.89
- glutamine - E72.89
- threonine - E72.89
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Disorder(of)
- amino-acid
- metabolism
- specified NEC
- Disorder(of)
- beta-amino-acid metabolism
- Disorder(of)
- gamma-glutamyl cycle
- Disorder(of)
- metabolism NOS
- amino-acid
- other specified
- Disorder(of)
- metabolism NOS
- amino-acid
- other specified
- beta-amino acid
- Disorder(of)
- metabolism NOS
- amino-acid
- other specified
- gamma-glutamyl cycle
- Disorder(of)
- metabolism NOS
- amino-acid
- straight-chain
- Disorder(of)
- metabolism NOS
- glutamine
- Disorder(of)
- metabolism NOS
- serine
- Disorder(of)
- metabolism NOS
- threonine
- Disturbance(s)
- metabolism
- amino-acid
- straight-chain
- Disturbance(s)
- metabolism
- glutamine
- Disturbance(s)
- metabolism
- threonine
- Syndrome
- fish odor
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Lysinuric Protein Intolerance
a disorder caused by the inability to digest and use lysine, arginine, and ornithine. lysinuric protein intolerance is caused by mutations in the slc7a7 gene. y+l amino acid transporter 1, the product of the slc7a7 gene, is involved in transporting lysine, arginine, and ornithine between cells in the body.
Patient EducationClinical
Amino Acid Metabolism Disorders
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code History & ChangesHistory
Replacement E72.89 replaces the following previously assigned code(s):
- E72.8 - Other specified disorders of amino-acid metabolism
Questions About E72.89Overview
Is E72.89 (Other specified disorders of amino-acid metabolism) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other specified disorders of amino-acid metabolism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
