2026 ICD-10-CM Diagnosis Code E72.59Other disorders of glycine metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E72

ICD-10-CM E72.59
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E72.59 is a billable ICD-10-CM diagnosis code for other disorders of glycine metabolism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as deficiency of dimethylglycine dehydrogenase. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E72.59
Billable Status
Yes — Valid for Submission
Code Describes
Other disorders of glycine metabolism
Short Description
Other disorders of glycine metabolism
Same as the full description in the CMS dataset.
Parent Code
E72.5
Disorders of glycine metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE72Other disorders of amino-acid metabolism
This CodeE72.59Other disorders of glycine metabolism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Deficiency of dimethylglycine dehydrogenase
  • Deficiency of glycine acyltransferase
  • Deficiency of sarcosine oxidase
  • Hyperprolinemia
  • Hyperprolinemia type 2
  • Proline dehydrogenase deficiency
  • Sarcosine dehydrogenase deficiency

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • D-glycericacidemia
  • Hyperhydroxyprolinemia
  • Hyperprolinemia (types I, II)
  • Sarcosinemia

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • d-glycericacidemia
    • Disorder(of)
      • glycine metabolism
        • d-glycericacidemia
    • Disorder(of)
      • glycine metabolism
        • hyperhydroxyprolinemia
    • Disorder(of)
      • glycine metabolism
        • hyperprolinemia
    • Disorder(of)
      • glycine metabolism
        • sarcosinemia
    • Disorder(of)
      • metabolism NOS
        • amino-acid
          • glycine
            • d-glycericacidemia
    • Disorder(of)
      • metabolism NOS
        • amino-acid
          • glycine
            • hyperhydroxyprolinemia
    • Disorder(of)
      • metabolism NOS
        • amino-acid
          • glycine
            • hyperprolinemia
    • Disorder(of)
      • metabolism NOS
        • amino-acid
          • glycine
            • other specified
    • Disorder(of)
      • metabolism NOS
        • amino-acid
          • glycine
            • sarcosinemia
    • Hydroxyprolinemia
    • Hyperhydroxyprolinemia
    • Hyperprolinemia(type I) (type II)
    • Sarcosinemia

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Amino Acid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E72.59 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
270.7 Straig amin-acid met NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E72.59Overview

Is E72.59 (Disorders of glycine metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of glycine metabolism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of E72.59?

Under the General Equivalence Mappings, other disorders of glycine metabolism converts to ICD-9-CM 270.7 (straig amin-acid met NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.