2027 ICD-10-CM Diagnosis Code E72.51Non-ketotic hyperglycinemia
ICD-10-CM Codes›E00–E89›E70-E88›E72
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
E72.51 is a billable ICD-10-CM diagnosis code for non-ketotic hyperglycinemia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 140 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
E72.51 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E72.51 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Aminomethyltransferase deficiency
- Atypical glycine encephalopathy
- Childhood-onset spasticity with hyperglycinemia
- Glucoglycinuria
- Glycine dehydrogenase deficiency
- Glycosuria
- Hyperglycinemia
- Infantile glycine encephalopathy
- Neonatal glycine encephalopathy
- Non-ketotic hyperglycinemia
- Non-ketotic hyperglycinemia H protein deficiency
- Non-ketotic hyperglycinemia L protein deficiency
- Spastic ataxia
- Transient neonatal hyperglycinemia
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E72.51: its own notes plus those printed at E72, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E72.51, its category, or a range that includes it.
Excludes1 3
These codes carry an Excludes1 note naming E72.51: they are not reported together with it, unless the two conditions are unrelated.
- R79 Other abnormal findings of blood chemistry
- R79.83 Abnormal findings of blood amino-acid level
- Block R80-R82 Abnormal findings on examination of urine, without diagnosis
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disorder (of) See Also: Disease;
Glucoglycinuria E72.51
Glycinemia E72.51
Non-ketotic hyperglycinemia E72.51
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Hyperglycinemia, Nonketotic
an autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial glycine cleavage system.
Patient EducationClinical
Amino Acid Metabolism Disorders
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E72.51 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E72.51Overview
What is the ICD-10 code for non-ketotic hyperglycinemia?
The ICD-10-CM code for non-ketotic hyperglycinemia is E72.51 (sometimes written as E7251). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E72.51 (Disorders of glycine metabolism) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report non-ketotic hyperglycinemia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E72.51 group to?
When non-ketotic hyperglycinemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Is E72.51 a CC or MCC?
CMS lists E72.51 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 140 closely related codes in its exclusion list.
Can E72.51 be reported with a code from E70?
Not as a rule. The Excludes1 note at E72, which applies to E72.51, lists "aromatic amino-acid metabolism (E70.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E72.51 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E72.51 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
