2026 ICD-10-CM Diagnosis Code E34.321Primary insulin-like growth factor-1 (IGF-1) deficiency

ICD-10-CM Codes›E00–E89›E20-E35›E34

ICD-10-CM E34.321
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E34.321 is a billable ICD-10-CM diagnosis code for primary insulin-like growth factor-1 (IGF-1) deficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. Coders also document this condition as growth delay due to insulin-like growth factor type 1 deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E34.321
Billable Status
Yes — Valid for Submission
Code Describes
Primary insulin-like growth factor-1 (IGF-1) deficiency
Short Description
Primary insulin-like growth factor-1 (IGF-1) deficiency
Same as the full description in the CMS dataset.
Parent Code
E34.32
Genetic causes of short stature

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE34Other endocrine disorders
This CodeE34.321Primary insulin-like growth factor-1 (IGF-1) deficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Growth delay due to insulin-like growth factor type 1 deficiency
  • Growth hormone receptor abnormality
  • Growth hormone receptor absent
  • Hereditary growth hormone deficiency
  • Laron syndrome with immunodeficiency
  • Laron-type isolated somatotropin defect
  • Short stature due to primary acid labile subunit deficiency

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Acid-labile subunit gene (IGFALS) defect
  • Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
  • Growth hormone insensitivity syndrome (GHIS)
  • Insulin-like growth factor 1 gene (IGF1) defect
  • Laron type short stature
  • Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
  • Signal transducer and activator of transcription 5B gene (STAT5b) defect

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dwarfism
      • Laron-type
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • due to
          • genetic causes
            • acid-labile subunit gene (IGFALS) defect
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • due to
          • genetic causes
            • growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • due to
          • genetic causes
            • growth hormone insensitivity syndrome (GHIS)
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • due to
          • genetic causes
            • insulin-like growth factor 1 gene (IGF1) defect
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • due to
          • genetic causes
            • primary insulin-like growth factor-1 (IGF-1) deficiency
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • due to
          • genetic causes
            • severe primary insulin-like growth factor-1 deficiency (SPIGFD)
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • due to
          • genetic causes
            • signal transducer and activator of transcription 5B gene (STAT5b) defect
    • Short, shortening, shortness
      • stature (child) (hereditary) (idiopathic) NEC
        • Laron-type

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Growth Disorders

Does your child seem much shorter - or much taller - than other kids his or her age? It could be normal. Some children may be small for their age but still be developing normally. Some children are short or tall because their parents are.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement E34.321 replaces the following previously assigned code(s):

  • E34.3 - Short stature due to endocrine disorder
FY 2023AddedAdded to the ICD-10-CM code setEffective October 1, 2022.
FY 2024–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E34.321Overview

Is E34.321 (Genetic causes of short stature) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report primary insulin-like growth factor-1 (IGF-1) deficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E34.321 group to?

When primary insulin-like growth factor-1 (IGF-1) deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.