2027 ICD-10-CM Diagnosis Code D70.4Cyclic neutropenia
ICD-10-CM Codes›D50–D89›D70-D77›D70
- Billable — Valid for Submission
- Risk Adjusts — HCC 115
- Chronic Condition
D70.4 is a billable ICD-10-CM diagnosis code for cyclic neutropenia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 808 through 810. Coders also document this condition as agranulocytosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.
For Medicare Advantage risk adjustment, D70.4 maps to CMS-HCC Category 115 (Specified Immunodeficiencies and White Blood Cell Disorders) under the V28 model, adding a risk factor of about 0.565 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D70.4 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Agranulocytosis
- Cyclical neutropenia
- Periodontitis exacerbated by cyclical neutropenia
- Secondary agranulocytosis
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D70.4: its own notes plus those printed at D70 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- agranulocytosis
- decreased absolute neurophile count (ANC)
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Cyclic hematopoiesis
- Periodic neutropenia
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Code Also
A second code may be needed to fully describe the condition; the note gives no sequencing direction.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D70.4, its category, or a range that includes it.
Excludes2 4
These codes carry an Excludes2 note naming D70.4: its condition is not part of those codes, and both may be reported when the patient has both.
- D61 Other aplastic anemias and other bone marrow failure syndromesneutropenia (D70.-) names D70.-, which includes this code
- D72 Other disorders of white blood cellsneutropenia (D70) names D70, which includes this code
- D72.81 Decreased white blood cell countneutropenia (D70) names D70, which includes this code
- Block R70-R79 Abnormal findings on examination of blood, without diagnosis
Code First 1
These codes say to code first a condition named in the note, and D70.4 is one of the conditions named.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Agranulocytosis (chronic) (cyclical) (genetic) (infantile) (periodic) (pernicious) See Also: Neutropenia; D70.9
secondary D70.4
Hematopoiesis, cyclic D70.4
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Cyclic Neutropenia
a hematologic disorder caused by a mutation in the elane (ela2) gene; clinical manifestations include recurrent neutropenia with resultant susceptibility to infection leading to fever.Neutropenia
a decrease in the number of neutrophils found in the blood.
Patient EducationClinical
Blood Disorders
Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D70.4 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D70.4Overview
What is the ICD-10 code for cyclic neutropenia?
The ICD-10-CM code for cyclic neutropenia is D70.4 (sometimes written as D704). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D70.4 (Neutropenia) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report cyclic neutropenia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D70.4 group to?
When cyclic neutropenia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0749 to 2.1706 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D70.4 be reported with D73.81?
Not as a rule. The Excludes1 note at D70, which applies to D70.4, lists "neutropenic splenomegaly (D73.81)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does D70.4 need an additional code?
When the condition applies, yes. The Use Additional Code note at D70, which applies to D70.4, reads: code for any associated: fever (R50.81). The additional code is reported after D70.4.
What HCC is D70.4?
D70.4 (cyclic neutropenia) maps to CMS-HCC Category 115 (Specified Immunodeficiencies and White Blood Cell Disorders), commonly written as HCC 115, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 47 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. It does not map to any RxHCC in the Part D prescription drug model.
Does D70.4 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D70.4 adds a risk adjustment factor of about 0.565 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.302 to 0.692 depending on the payment segment). A more severe related category (HCC 114) supersedes it when both are reported. See the full factor table on the HCC 115 category page.
