2026 ICD-10-CM Diagnosis Code D57.1Sickle-cell disease without crisis

ICD-10-CM Codes›D50–D89›D55-D59›D57

ICD-10-CM D57.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D57.1 is a billable ICD-10-CM diagnosis code for sickle-cell disease without crisis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sickle cell trait/anemia.

Code Identity

ICD-10-CM Code
D57.1
Billable Status
Yes — Valid for Submission
Code Describes
Sickle-cell disease without crisis
Short Description
Sickle-cell disease without crisis
Same as the full description in the CMS dataset.
Parent Code
D57
Sickle-cell disorders

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD57Sickle-cell disorders
This CodeD57.1Sickle-cell disease without crisis

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Arthropathy secondary to hemoglobinopathy
  • Bilateral nonproliferative retinopathy due to sickle cell disease
  • Bilateral proliferative retinopathy due to sickle cell disease
  • Disorder of myocardium due to sickle cell hemoglobinopathy
  • Double heterozygous sickling disorder
  • Focal segmental glomerulosclerosis
  • Focal segmental glomerulosclerosis due to sickle cell disease
  • Glomerular disease due to double heterozygous sickling disorder
  • Glomerular disease due to hematological disease
  • Gouty arthropathy due to double heterozygous sickling disorder
  • Hemoglobin S sickling disorder without crisis
  • Hemoglobin SS disease without crisis
  • Hereditary persistence of fetal hemoglobin
  • Hereditary persistence of fetal hemoglobin with sickle cell disease syndrome
  • Nondiabetic proliferative retinopathy
  • Non-diabetic proliferative retinopathy of bilateral eyes
  • Nonproliferative retinopathy of left eye due to sickle cell disease
  • Nonproliferative retinopathy of right eye due to sickle cell disease
  • Nonproliferative sickle cell retinopathy
  • Papillary necrosis
  • Priapism
  • Priapism due to sickle cell disease
  • Proliferative retinopathy due to sickle cell disease
  • Proliferative retinopathy of bilateral eyes
  • Proliferative retinopathy of left eye due to sickle cell disease
  • Proliferative retinopathy of right eye due to sickle cell disease
  • Renal papillary necrosis due to sickle cell disease
  • Sickle cell anemia in mother complicating childbirth
  • Sickle cell anemia with coexistent alpha-thalassemia
  • Sickle cell arthropathy
  • Sickle cell hepatopathy
  • Sickle cell nephropathy
  • Sickle cell retinopathy
  • Sickle cell-hemoglobin SS disease
  • Sickle cell-thalassemia disease
  • Sickling disorder due to hemoglobin S

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Hb-SS disease without crisis
  • Sickle-cell anemia NOS
  • Sickle-cell disease NOS
  • Sickle-cell disorder NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • Herrick's
    • Disease, diseased
      • hemoglobin or Hb
        • S or SS
    • Disease, diseased
      • sickle-cell
    • Hemoglobinopathy(mixed)
      • sickle-cell

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD005
Sickle cell trait/anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Priapism

    a prolonged painful erection that may lasts hours and is not associated with sexual activity. it is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma; and certain drug treatments.

  • Sickle Cell Nephropathy

    nephropathy secondary to sickle cell disease, characterized by the presence of sickled erythrocytes in the renal medullary vessels, renal ischemia and microinfarctions, renal papillary necrosis, and renal tubular abnormalities.

  • Hereditary Persistence of Fetal Hemoglobin

    the persistence of substantial fetal hemoglobin production into adulthood, usually associated with hemoglobinopathies due to mutations in the alpha and/or beta chain of hemoglobin.

  • Priapism

    persistent and usually painful erection that lasts for at least four hours in the absence of physical or psychological stimulation, which can be caused by hematologic disorders, including sickle cell disease and leukemia, spinal cord injuries, and medications.

Patient EducationClinical

Sickle Cell Disease

Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.

The full article covers:

  • What is sickle cell disease (SCD)?
  • What causes sickle cell disease (SCD)?
  • Who is more likely to have sickle cell disease (SCD)?
  • What are the symptoms of sickle cell disease (SCD)?
  • How is sickle cell disease (SCD) diagnosed?
  • What are the treatments for sickle cell disease (SCD)?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D57.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
282.60 Sickle cell disease NOS
Approximate The match is approximate rather than exact.
ICD-9-CM
282.61 Hb-SS disease w/o crisis
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D57.1Overview

Is D57.1 (Sickle-cell disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report sickle-cell disease without crisis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D57.1 group to?

When sickle-cell disease without crisis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D57.1?

Under the General Equivalence Mappings, sickle-cell disease without crisis converts to ICD-9-CM 282.60 (sickle cell disease NOS) and 282.61 (Hb-SS disease w/o crisis). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.