2027 ICD-10-CM Diagnosis Code D57.1Sickle-cell disease without crisis
ICD-10-CM Codes›D50–D89›D55-D59›D57
- Billable — Valid for Submission
- Risk Adjusts — HCC 107
- Chronic Condition
D57.1 is a billable ICD-10-CM diagnosis code for sickle-cell disease without crisis. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sickle cell trait/anemia.
For Medicare Advantage risk adjustment, D57.1 maps to CMS-HCC Category 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) under the V28 model, adding a risk factor of about 0.457 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D57.1 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Arthropathy secondary to hemoglobinopathy
- Bilateral nonproliferative retinopathy due to sickle cell disease
- Bilateral proliferative retinopathy due to sickle cell disease
- Disorder of myocardium due to sickle cell hemoglobinopathy
- Double heterozygous sickling disorder
- Focal segmental glomerulosclerosis
- Focal segmental glomerulosclerosis due to sickle cell disease
- Glomerular disease due to double heterozygous sickling disorder
- Glomerular disease due to hematological disease
- Gouty arthropathy due to double heterozygous sickling disorder
- Hemoglobin S sickling disorder without crisis
- Hemoglobin SS disease without crisis
- Hereditary persistence of fetal hemoglobin
- Hereditary persistence of fetal hemoglobin with sickle cell disease syndrome
- Nondiabetic proliferative retinopathy
- Non-diabetic proliferative retinopathy of bilateral eyes
- Nonproliferative retinopathy of left eye due to sickle cell disease
- Nonproliferative retinopathy of right eye due to sickle cell disease
- Nonproliferative sickle cell retinopathy
- Papillary necrosis
- Priapism
- Priapism due to sickle cell disease
- Proliferative retinopathy due to sickle cell disease
- Proliferative retinopathy of bilateral eyes
- Proliferative retinopathy of left eye due to sickle cell disease
- Proliferative retinopathy of right eye due to sickle cell disease
- Renal papillary necrosis due to sickle cell disease
- Sickle cell anemia in mother complicating childbirth
- Sickle cell anemia with coexistent alpha-thalassemia
- Sickle cell arthropathy
- Sickle cell hepatopathy
- Sickle cell nephropathy
- Sickle cell retinopathy
- Sickle cell-hemoglobin SS disease
- Sickle cell-thalassemia disease
- Sickling disorder due to hemoglobin S
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D57.1: its own notes plus those printed at D57 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Hb-SS disease without crisis
- Sickle-cell anemia NOS
- Sickle-cell disease NOS
- Sickle-cell disorder NOS
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D57.1, its category, or a range that includes it.
Excludes1 2
These codes carry an Excludes1 note naming D57.1: they are not reported together with it, unless the two conditions are unrelated.
- D56.8 Other thalassemiassickle-cell anemia (D57.-) names D57.-, which includes this code
- Block P50-P61 Hemorrhagic and hematological disorders of newborn
Code First 4
These codes say to code first a condition named in the note, and D57.1 is one of the conditions named.
- H36 Retinal disorders in diseases classified elsewheresickle-cell disorders (D57.-) names D57.-, which includes this code
- M14.8 Arthropathies in other specified diseases classified elsewheresickle-cell disorders (D57.-) names D57.-, which includes this code
- R50.81 Fever presenting with conditions classified elsewheresickle-cell disease (D57.-) names D57.-, which includes this code
- N08 Glomerular disorders in diseases classified elsewhere
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
Herrick's D57.1
Disease, diseased See Also: Syndrome;
S or SS D57.1
sickle-cell D57.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Anemia, Sickle Cell
a disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. it is the clinical expression of homozygosity for hemoglobin s.
Patient EducationClinical
Sickle Cell Disease
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.
The full article covers:
- What is sickle cell disease (SCD)?
- What causes sickle cell disease (SCD)?
- Who is more likely to have sickle cell disease (SCD)?
- What are the symptoms of sickle cell disease (SCD)?
- How is sickle cell disease (SCD) diagnosed?
- What are the treatments for sickle cell disease (SCD)?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D57.1 to ICD-9-CMHistory
Code HistoryHistory
Questions About D57.1Overview
What is the ICD-10 code for sickle-cell disease without crisis?
The ICD-10-CM code for sickle-cell disease without crisis is D57.1 (sometimes written as D571). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D57.1 (Sickle-cell disorders) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report sickle-cell disease without crisis on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D57.1 group to?
When sickle-cell disease without crisis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 812, 811, with relative weights from 0.9237 to 1.3991 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D57.1 be reported with a code from D58?
Not as a rule. The Excludes1 note at D57, which applies to D57.1, lists "other hemoglobinopathies (D58.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does D57.1 need an additional code?
When the condition applies, yes. The Use Additional Code note at D57, which applies to D57.1, reads: code for any associated fever (R50.81). The additional code is reported after D57.1.
What HCC is D57.1?
D57.1 (sickle-cell disease without crisis) maps to CMS-HCC Category 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero), commonly written as HCC 107, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 46 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 95.
Does D57.1 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D57.1 adds a risk adjustment factor of about 0.457 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.303 to 1.939 depending on the payment segment). HCC 107 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 107 category page.
