2026 ICD-10-CM Diagnosis Code D57.1Sickle-cell disease without crisis
ICD-10-CM Codes›D50–D89›D55-D59›D57
- Billable — Valid for Submission
- Risk Adjusts — HCC 107
- Chronic Condition
D57.1 is a billable ICD-10-CM diagnosis code for sickle-cell disease without crisis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sickle cell trait/anemia.
For Medicare Advantage risk adjustment, D57.1 maps to CMS-HCC Category 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) under the V28 model, adding a risk factor of about 0.457 for a community, non-dual, aged beneficiary in payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D57.1 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2026.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Arthropathy secondary to hemoglobinopathy
- Bilateral nonproliferative retinopathy due to sickle cell disease
- Bilateral proliferative retinopathy due to sickle cell disease
- Disorder of myocardium due to sickle cell hemoglobinopathy
- Double heterozygous sickling disorder
- Focal segmental glomerulosclerosis
- Focal segmental glomerulosclerosis due to sickle cell disease
- Glomerular disease due to double heterozygous sickling disorder
- Glomerular disease due to hematological disease
- Gouty arthropathy due to double heterozygous sickling disorder
- Hemoglobin S sickling disorder without crisis
- Hemoglobin SS disease without crisis
- Hereditary persistence of fetal hemoglobin
- Hereditary persistence of fetal hemoglobin with sickle cell disease syndrome
- Nondiabetic proliferative retinopathy
- Non-diabetic proliferative retinopathy of bilateral eyes
- Nonproliferative retinopathy of left eye due to sickle cell disease
- Nonproliferative retinopathy of right eye due to sickle cell disease
- Nonproliferative sickle cell retinopathy
- Papillary necrosis
- Priapism
- Priapism due to sickle cell disease
- Proliferative retinopathy due to sickle cell disease
- Proliferative retinopathy of bilateral eyes
- Proliferative retinopathy of left eye due to sickle cell disease
- Proliferative retinopathy of right eye due to sickle cell disease
- Renal papillary necrosis due to sickle cell disease
- Sickle cell anemia in mother complicating childbirth
- Sickle cell anemia with coexistent alpha-thalassemia
- Sickle cell arthropathy
- Sickle cell hepatopathy
- Sickle cell nephropathy
- Sickle cell retinopathy
- Sickle cell-hemoglobin SS disease
- Sickle cell-thalassemia disease
- Sickling disorder due to hemoglobin S
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Hb-SS disease without crisis
- Sickle-cell anemia NOS
- Sickle-cell disease NOS
- Sickle-cell disorder NOS
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
Herrick's D57.1
Disease, diseased See Also: Syndrome;
S or SS D57.1
sickle-cell D57.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Priapism
a prolonged painful erection that may lasts hours and is not associated with sexual activity. it is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma; and certain drug treatments.Sickle Cell Nephropathy
nephropathy secondary to sickle cell disease, characterized by the presence of sickled erythrocytes in the renal medullary vessels, renal ischemia and microinfarctions, renal papillary necrosis, and renal tubular abnormalities.Hereditary Persistence of Fetal Hemoglobin
the persistence of substantial fetal hemoglobin production into adulthood, usually associated with hemoglobinopathies due to mutations in the alpha and/or beta chain of hemoglobin.Priapism
persistent and usually painful erection that lasts for at least four hours in the absence of physical or psychological stimulation, which can be caused by hematologic disorders, including sickle cell disease and leukemia, spinal cord injuries, and medications.
Patient EducationClinical
Sickle Cell Disease
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.
The full article covers:
- What is sickle cell disease (SCD)?
- What causes sickle cell disease (SCD)?
- Who is more likely to have sickle cell disease (SCD)?
- What are the symptoms of sickle cell disease (SCD)?
- How is sickle cell disease (SCD) diagnosed?
- What are the treatments for sickle cell disease (SCD)?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D57.1 to ICD-9-CMHistory
Code HistoryHistory
Questions About D57.1Overview
What is the ICD-10 code for sickle-cell disease without crisis?
The ICD-10-CM code for sickle-cell disease without crisis is D57.1 (sometimes written as D571). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is D57.1 (Sickle-cell disorders) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report sickle-cell disease without crisis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D57.1 group to?
When sickle-cell disease without crisis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D57.1?
Under the General Equivalence Mappings, sickle-cell disease without crisis converts to ICD-9-CM 282.60 (sickle cell disease NOS) and 282.61 (Hb-SS disease w/o crisis). The mapping is approximate, so confirm the match fits the documentation.
What HCC is D57.1?
D57.1 (sickle-cell disease without crisis) maps to CMS-HCC Category 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero), commonly written as HCC 107, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2026. It mapped to HCC 46 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 95.
Does D57.1 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D57.1 adds a risk adjustment factor of about 0.457 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.303 to 1.939 depending on the payment segment). HCC 107 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 107 category page.
