HCC 108: Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major ICD-10-CM
CMS-HCC Category 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major) is a payment HCC in the V28 Medicare Advantage risk adjustment model. For payment year 2026 it adds a risk adjustment factor between 0.098 and 0.416 to a beneficiary's RAF score depending on the payment segment (0.146 for a community, non-dual, aged enrollee). 39 ICD-10-CM diagnosis codes map to HCC 108. A more severe related category (HCC 107) supersedes it when both are reported.
RAF Weight by Payment Segment 7 segments
| Payment Segment | Relative Factor |
|---|---|
| Community, non-dual, aged | 0.146 |
| Community, partial-benefit dual, aged | 0.303 |
| Community, full-benefit dual, aged | 0.103 |
| Community, non-dual, disabled | 0.386 |
| Community, partial-benefit dual, disabled | 0.416 |
| Community, full-benefit dual, disabled | 0.408 |
| Institutional | 0.098 |
A beneficiary is scored in exactly one segment, set by Medicaid (dual) status, aged or disabled entitlement, and residence. Factors are relative weights, not dollar amounts; new-enrollee segments score on demographics only. In the hierarchy, HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) supersedes HCC 108 when reported together.
ICD-10-CM Codes That Map to HCC 108 39 codes
- D56.1 Beta thalassemia from V24 HCC 48
- D56.2 Delta-beta thalassemia from V24 HCC 48
- D56.5 Hemoglobin E-beta thalassemia from V24 HCC 48
- D57.20 Sickle-cell/Hb-C disease without crisis from V24 HCC 46
- D57.211 Sickle-cell/Hb-C disease with acute chest syndrome from V24 HCC 46
- D57.212 Sickle-cell/Hb-C disease with splenic sequestration from V24 HCC 46
- D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement from V24 HCC 46
- D57.214 Sickle-cell/Hb-C disease with dactylitis from V24 HCC 46
- D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication from V24 HCC 46
- D57.219 Sickle-cell/Hb-C disease with crisis, unspecified from V24 HCC 46
- D57.40 Sickle-cell thalassemia without crisis from V24 HCC 46
- D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome from V24 HCC 46
- D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration from V24 HCC 46
- D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement from V24 HCC 46
- D57.414 Sickle-cell thalassemia, unspecified, with dactylitis from V24 HCC 46
- D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication from V24 HCC 46
- D57.419 Sickle-cell thalassemia, unspecified, with crisis from V24 HCC 46
- D57.44 Sickle-cell thalassemia beta plus without crisis from V24 HCC 46
- D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome from V24 HCC 46
- D57.452 Sickle-cell thalassemia beta plus with splenic sequestration from V24 HCC 46
- D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement from V24 HCC 46
- D57.454 Sickle-cell thalassemia beta plus with dactylitis from V24 HCC 46
- D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication from V24 HCC 46
- D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified from V24 HCC 46
- D57.80 Other sickle-cell disorders without crisis from V24 HCC 46
- D57.811 Other sickle-cell disorders with acute chest syndrome from V24 HCC 46
- D57.812 Other sickle-cell disorders with splenic sequestration from V24 HCC 46
- D57.813 Other sickle-cell disorders with cerebral vascular involvement from V24 HCC 46
- D57.814 Other sickle-cell disorders with dactylitis from V24 HCC 46
- D57.818 Other sickle-cell disorders with crisis with other specified complication from V24 HCC 46
- D57.819 Other sickle-cell disorders with crisis, unspecified from V24 HCC 46
- H36.811 Nonproliferative sickle-cell retinopathy, right eye from V24 HCC 46
- H36.812 Nonproliferative sickle-cell retinopathy, left eye from V24 HCC 46
- H36.813 Nonproliferative sickle-cell retinopathy, bilateral from V24 HCC 46
- H36.819 Nonproliferative sickle-cell retinopathy, unspecified eye from V24 HCC 46
- H36.821 Proliferative sickle-cell retinopathy, right eye from V24 HCC 46, HCC 122
- H36.822 Proliferative sickle-cell retinopathy, left eye from V24 HCC 46, HCC 122
- H36.823 Proliferative sickle-cell retinopathy, bilateral from V24 HCC 46, HCC 122
- H36.829 Proliferative sickle-cell retinopathy, unspecified eye from V24 HCC 46, HCC 122
Every code above carries the full HCC 108 weight when documented and reported on a Medicare Advantage encounter. The code link opens its full page with the complete risk adjustment card.
Questions About HCC 108
What is HCC 108 in the CMS-HCC model?
HCC 108 is CMS-HCC Category 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major) in the V28 risk adjustment model. It covers 39 ICD-10-CM diagnosis codes that raise a Medicare Advantage beneficiary's risk score when documented.
What is the RAF weight for HCC 108?
For payment year 2026, HCC 108 adds 0.146 to the RAF score of a community, non-dual, aged beneficiary (living at home, age 65 or over, not also enrolled in Medicaid). The published weights range from 0.098 to 0.416 across the seven payment segments shown above.
Which categories supersede HCC 108?
HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) sits above HCC 108 in the hierarchy: when a beneficiary has diagnoses in both, only the more severe category is paid.
Related References
Source: Centers for Medicare & Medicaid Services, Payment Year 2026 risk adjustment mapping and model software releases (CMS-HCC V28), applied to the FY 2026 ICD-10-CM code set. ICD List is not affiliated with CMS.
