HCC 108: Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major ICD-10-CM
CMS-HCC Category 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major) is a payment HCC in the V28 Medicare Advantage risk adjustment model. For payment year 2026 it adds a risk adjustment factor between 0.098 and 0.416 to a beneficiary's RAF score depending on the payment segment (0.146 for a community, non-dual, aged enrollee). 39 ICD-10-CM diagnosis codes map to HCC 108. A more severe related category (HCC 107) supersedes it when both are reported.
RAF Weight by Payment Segment 7 segments
| Payment Segment | Relative Factor |
|---|---|
| Community, non-dual, aged | 0.146 |
| Community, partial-benefit dual, aged | 0.303 |
| Community, full-benefit dual, aged | 0.103 |
| Community, non-dual, disabled | 0.386 |
| Community, partial-benefit dual, disabled | 0.416 |
| Community, full-benefit dual, disabled | 0.408 |
| Institutional | 0.098 |
A beneficiary is scored in exactly one segment, set by Medicaid (dual) status, aged or disabled entitlement, and residence. Factors are relative weights, not dollar amounts; new-enrollee segments score on demographics only. In the hierarchy, HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) supersedes HCC 108 when reported together.
ICD-10-CM Codes That Map to HCC 108 39 codes
- D56.1 Beta thalassemia from V24 HCC 48
- D56.2 Delta-beta thalassemia from V24 HCC 48
- D56.5 Hemoglobin E-beta thalassemia from V24 HCC 48
- D57.20 Sickle-cell/Hb-C disease without crisis from V24 HCC 46
- D57.211 Sickle-cell/Hb-C disease with acute chest syndrome from V24 HCC 46
- D57.212 Sickle-cell/Hb-C disease with splenic sequestration from V24 HCC 46
- D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement from V24 HCC 46
- D57.214 Sickle-cell/Hb-C disease with dactylitis from V24 HCC 46
- D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication from V24 HCC 46
- D57.219 Sickle-cell/Hb-C disease with crisis, unspecified from V24 HCC 46
- D57.40 Sickle-cell thalassemia without crisis from V24 HCC 46
- D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome from V24 HCC 46
- D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration from V24 HCC 46
- D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement from V24 HCC 46
- D57.414 Sickle-cell thalassemia, unspecified, with dactylitis from V24 HCC 46
- D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication from V24 HCC 46
- D57.419 Sickle-cell thalassemia, unspecified, with crisis from V24 HCC 46
- D57.44 Sickle-cell thalassemia beta plus without crisis from V24 HCC 46
- D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome from V24 HCC 46
- D57.452 Sickle-cell thalassemia beta plus with splenic sequestration from V24 HCC 46
- D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement from V24 HCC 46
- D57.454 Sickle-cell thalassemia beta plus with dactylitis from V24 HCC 46
- D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication from V24 HCC 46
- D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified from V24 HCC 46
- D57.80 Other sickle-cell disorders without crisis from V24 HCC 46
- D57.811 Other sickle-cell disorders with acute chest syndrome from V24 HCC 46
- D57.812 Other sickle-cell disorders with splenic sequestration from V24 HCC 46
- D57.813 Other sickle-cell disorders with cerebral vascular involvement from V24 HCC 46
- D57.814 Other sickle-cell disorders with dactylitis from V24 HCC 46
- D57.818 Other sickle-cell disorders with crisis with other specified complication from V24 HCC 46
- D57.819 Other sickle-cell disorders with crisis, unspecified from V24 HCC 46
- H36.811 Nonproliferative sickle-cell retinopathy, right eye from V24 HCC 46
- H36.812 Nonproliferative sickle-cell retinopathy, left eye from V24 HCC 46
- H36.813 Nonproliferative sickle-cell retinopathy, bilateral from V24 HCC 46
- H36.819 Nonproliferative sickle-cell retinopathy, unspecified eye from V24 HCC 46
- H36.821 Proliferative sickle-cell retinopathy, right eye from V24 HCC 46, HCC 122
- H36.822 Proliferative sickle-cell retinopathy, left eye from V24 HCC 46, HCC 122
- H36.823 Proliferative sickle-cell retinopathy, bilateral from V24 HCC 46, HCC 122
- H36.829 Proliferative sickle-cell retinopathy, unspecified eye from V24 HCC 46, HCC 122
Every code above carries the full HCC 108 weight when documented and reported on a Medicare Advantage encounter. The code link opens its full page with the complete risk adjustment card.
Questions About HCC 108
What is HCC 108 in the CMS-HCC model?
HCC 108 is CMS-HCC Category 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major) in the V28 risk adjustment model. It covers 39 ICD-10-CM diagnosis codes that raise a Medicare Advantage beneficiary's risk score when documented.
What is the RAF weight for HCC 108?
For payment year 2026, HCC 108 adds 0.146 to the RAF score of a community, non-dual, aged beneficiary. The published weights range from 0.098 to 0.416 across the seven payment segments shown above.
Which categories supersede HCC 108?
HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) sits above HCC 108 in the hierarchy: when a beneficiary has diagnoses in both, only the more severe category is paid.
Related References
Source: Centers for Medicare & Medicaid Services, Payment Year 2026 risk adjustment mapping and model software releases (CMS-HCC V28), applied to the FY 2026 ICD-10-CM code set. ICD List is not affiliated with CMS.
