2027 ICD-10-CM Diagnosis Code T45.525AAdverse effect of antithrombotic drugs, initial encounter

ICD-10-CM T45.525A

CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T45.525A is a billable ICD-10-CM diagnosis code for adverse effect of antithrombotic drugs, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. Coders also document this condition as a series prostaglandin adverse reaction. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code

T45.525A

Billable Status

Yes — Valid for Submission

Code Describes

Adverse effect of antithrombotic drugs, initial encounter

Short Description

Adverse effect of antithrombotic drugs, initial encounter

Same as the full description in the CMS dataset.

Parent Code

T45.525

Adverse effect of antithrombotic drugs

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes

SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

CategoryT45Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified

This CodeT45.525AAdverse effect of antithrombotic drugs, initial encounter

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T45.525A.

Unacceptable principal diagnosis

There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

A series prostaglandin adverse reaction
Adverse reaction to clopidogrel
Adverse reaction to platelet aggregation inhibitor
Duodenal ulcer caused by drug
Duodenal ulcer induced by platelet aggregation inhibitor
Epoprostenol adverse reaction
Gastric ulcer caused by drug
Gastric ulcer induced by platelet aggregation inhibitor
I series prostaglandin adverse reaction
Prostaglandin adverse reaction

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (T45). Use the following options for the applicable episode of care:

A - initial encounter
D - subsequent encounter
S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T45.525A: its own notes plus those printed at T45.52, T45, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.