2026 ICD-10-CM Diagnosis Code T45.0X2SPoisoning by antiallergic and antiemetic drugs, intentional self-harm, sequela
T45.0X2S is a billable ICD-10-CM diagnosis code for poisoning by antiallergic and antiemetic drugs, intentional self-harm, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders; sequela; and Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T45.0X2S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- 5-HT3-receptor antagonist overdose
- 5-HT3-receptor antagonist poisoning
- Antitussive agent overdose
- Chlorphenamine overdose
- Chlorphenamine poisoning
- Diphenhydramine overdose
- Diphenylpyraline overdose
- Domperidone overdose
- Domperidone poisoning
- Intentional 5-HT3-receptor antagonist overdose
- Intentional 5-HT3-receptor antagonist poisoning
- Intentional chlorphenamine overdose
- Intentional chlorphenamine poisoning
- Intentional diphenhydramine overdose
- Intentional diphenhydramine poisoning
- Intentional diphenylpyraline overdose
- Intentional diphenylpyraline poisoning
- Intentional domperidone overdose
- Intentional domperidone poisoning
- Intentional metoclopramide overdose
- Intentional metoclopramide poisoning
- Intentional thonzylamine overdose
- Intentional tripelennamine overdose
- Metoclopramide overdose
- Metoclopramide poisoning
- Poisoning by diphenhydramine
- Poisoning by diphenylpyraline
- Poisoning by thonzylamine
- Poisoning by tripelennamine
- Thonzylamine overdose
- Tripelennamine overdose
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (T45). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Astemizole
antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.Brompheniramine
histamine h1 antagonist used in treatment of allergies, rhinitis, and urticaria.Cetirizine
a potent second-generation histamine h1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.Chlorpheniramine
a histamine h1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. it has also been used in veterinary applications. one of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.Cinnarizine
a piperazine derivative having histamine h1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces parkinsonian disorders.Clemastine
a histamine h1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. it causes drowsiness.Cyclizine
a histamine h1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (from martindale, the extra pharmacopoeia, 30th ed, p935)Cyproheptadine
a serotonin antagonist and a histamine h1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.Dimenhydrinate
a drug combination that contains diphenhydramine and theophylline. it is used for treating vertigo, motion sickness, and nausea associated with pregnancy.Dimethindene
a histamine h1 antagonist. it is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.Diphenhydramine
a histamine h1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. it has some undesired antimuscarinic and sedative effects.Domperidone
a specific blocker of dopamine receptors. it speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.Doxylamine
histamine h1 antagonist with pronounced sedative properties. it is used in allergies and as an antitussive, antiemetic, and hypnotic. doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.Granisetron
a serotonin receptor (5ht-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.Ketotifen
a cycloheptathiophene blocker of histamine h1 receptors and release of inflammatory mediators. it has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.Methapyrilene
histamine h1 antagonist with sedative action used as a hypnotic and in allergies.Metoclopramide
a dopamine d2 antagonist that is used as an antiemetic.Ondansetron
a competitive serotonin type 3 receptor antagonist. it is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.Pheniramine
one of the histamine h1 antagonists with little sedative action. it is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.Pyrilamine
a histamine h1 antagonist. it has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. it is a common ingredient of cold remedies.Terfenadine
a selective histamine h1-receptor antagonist devoid of central nervous system depressant activity. the drug was used for allergy but withdrawn due to causing long qt syndrome.Tripelennamine
a histamine h1 antagonist with low sedative action but frequent gastrointestinal irritation. it is used to treat asthma; hay fever; urticaria; and rhinitis; and also in veterinary applications. tripelennamine is administered by various routes, including topically.Triprolidine
histamine h1 antagonist used in allergic rhinitis; asthma; and urticaria. it is a component of cough and cold medicines. it may cause drowsiness.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Convert T45.0X2S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T45.0X2SOverview
Is T45.0X2S a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by antiallergic and antiemetic drugs, intentional self-harm, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T45.0X2S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the poisoning by antiallergic and antiemetic drugs, intentional self-harm itself has resolved, not the original event.
What MS-DRG does T45.0X2S group to?
When poisoning by antiallergic and antiemetic drugs, intentional self-harm, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T45.0X2S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for poisoning by antiallergic and antiemetic drugs, intentional self-harm, sequela on inpatient claims.
What is the ICD-9 equivalent of T45.0X2S?
Under the General Equivalence Mappings, poisoning by antiallergic and antiemetic drugs, intentional self-harm, sequela converts to ICD-9-CM 909.0 (late eff drug poisoning) and E959 (late eff of self-injury). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
