2026 ICD-10-CM Diagnosis Code E84.8Cystic fibrosis with other manifestations

ICD-10-CM Codes›E00–E89›E70-E88›E84

ICD-10-CM E84.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E84.8 is a billable ICD-10-CM diagnosis code for cystic fibrosis with other manifestations. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Cystic fibrosis.

Code Identity

ICD-10-CM Code
E84.8
Billable Status
Yes — Valid for Submission
Code Describes
Cystic fibrosis with other manifestations
Short Description
Cystic fibrosis with other manifestations
Same as the full description in the CMS dataset.
Parent Code
E84
Cystic fibrosis

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE84Cystic fibrosis
This CodeE84.8Cystic fibrosis with other manifestations

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Arthropathy associated with cystic fibrosis
  • Azoospermia with absent vasa in association with cystic fibrosis trait
  • Congenital obstructive azoospermia
  • Cystic fibrosis of pancreas
  • Cystic fibrosis transmembrane conductance regulator-related metabolic syndrome
  • Cystic fibrosis with gastritis and megaloblastic anemia syndrome
  • Exocrine pancreatic manifestation co-occurrent and due to cystic fibrosis
  • Female infertility due to cystic fibrosis
  • Female infertility due to genetic disease
  • Gastritis caused by Helicobacter
  • Helicobacter pylori-associated gastritis
  • Liver cirrhosis due to classical cystic fibrosis
  • Liver disease due to cystic fibrosis
  • Liver enzymes level above reference range due to cystic fibrosis
  • Male infertility due to cystic fibrosis
  • Male infertility of genetic origin
  • Osteoporosis due to cystic fibrosis
  • Otorhinolaryngological manifestation co-occurrent and due to cystic fibrosis
  • Pancreatic insufficiency
  • Pancreatic insufficiency due to cystic fibrosis of pancreas
  • Polyneuropathy due to classical cystic fibrosis
  • Portal hypertension
  • Portal hypertension due to cystic fibrosis
  • Venous hypertension

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Fibrosis, fibrotic
      • cystic (of pancreas)
        • with
          • specified manifestations NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END012
Cystic fibrosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Calgranulin A

    a 10.8-kda member of the s-100 family of calcium-binding proteins that can form homo- or heterocomplexes with calgranulin b and a variety of other proteins. the calgranulin a/b heterodimer is known as leukocyte l1 antigen complex. calgranulin a is found in many cell types including granulocytes; keratinocytes; and myelomonocytes, and has been shown to act as a chemotactic substance for neutrophils. because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.

  • Cystic Fibrosis

    an autosomal recessive genetic disease of the exocrine glands. it is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator expressed in several organs including the lung, the pancreas, the biliary system, and the sweat glands. cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in airway obstruction; chronic respiratory infections; pancreatic insufficiency; maldigestion; salt depletion; and heat prostration.

  • Cystic Fibrosis Transmembrane Conductance Regulator

    a chloride channel that regulates secretion in many exocrine tissues. abnormalities in the cftr gene have been shown to cause cystic fibrosis. (hum genet 1994;93(4):364-8)

Patient EducationClinical

Cystic Fibrosis

Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses, and sex organs. CF causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E84.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
277.09 Cystic fibrosis NEC
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E84.8Overview

Is E84.8 (Cystic fibrosis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report cystic fibrosis with other manifestations on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E84.8 group to?

When cystic fibrosis with other manifestations is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E84.8?

Under the General Equivalence Mappings, cystic fibrosis with other manifestations converts to ICD-9-CM 277.09 (cystic fibrosis NEC). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.