2027 ICD-10-CM Diagnosis Code E84.8Cystic fibrosis with other manifestations
ICD-10-CM Codes›E00–E89›E70-E88›E84
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 277
- Chronic Condition
E84.8 is a billable ICD-10-CM diagnosis code for cystic fibrosis with other manifestations. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 640 through 641. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 5 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Cystic fibrosis.
For Medicare Advantage risk adjustment, E84.8 maps to CMS-HCC Category 277 (Cystic Fibrosis) under the V28 model, adding a risk factor of about 0.998 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E84.8 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Arthropathy associated with cystic fibrosis
- Azoospermia with absent vasa in association with cystic fibrosis trait
- Congenital obstructive azoospermia
- Cystic fibrosis of pancreas
- Cystic fibrosis transmembrane conductance regulator-related metabolic syndrome
- Cystic fibrosis with gastritis and megaloblastic anemia syndrome
- Exocrine pancreatic manifestation co-occurrent and due to cystic fibrosis
- Female infertility due to cystic fibrosis
- Female infertility due to genetic disease
- Gastritis caused by Helicobacter
- Helicobacter pylori-associated gastritis
- Liver cirrhosis due to classical cystic fibrosis
- Liver disease due to cystic fibrosis
- Liver enzymes level above reference range due to cystic fibrosis
- Male infertility due to cystic fibrosis
- Male infertility of genetic origin
- Osteoporosis due to cystic fibrosis
- Otorhinolaryngological manifestation co-occurrent and due to cystic fibrosis
- Pancreatic insufficiency
- Pancreatic insufficiency due to cystic fibrosis of pancreas
- Polyneuropathy due to classical cystic fibrosis
- Portal hypertension
- Portal hypertension due to cystic fibrosis
- Venous hypertension
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E84.8: its own notes plus those printed at E84, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Code Also
A second code may be needed to fully describe the condition; the note gives no sequencing direction.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E84.8, its category, or a range that includes it.
Excludes1 3
These codes carry an Excludes1 note naming E84.8: they are not reported together with it, unless the two conditions are unrelated.
Excludes2 2
These codes carry an Excludes2 note naming E84.8: its condition is not part of those codes, and both may be reported when the patient has both.
- Block J40-J4B Chronic lower respiratory diseasescystic fibrosis (E84.-) names E84.-, which includes this code
- K86 Other diseases of pancreasfibrocystic disease of pancreas (E84.-) names E84.-, which includes this code
Code First 3
These codes say to code first a condition named in the note, and E84.8 is one of the conditions named.
- E08 Diabetes mellitus due to underlying conditioncystic fibrosis (E84.-) names E84.-, which includes this code
- J93.12 Secondary spontaneous pneumothoraxcystic fibrosis (E84.-) names E84.-, which includes this code
- Q55.3 Atresia of vas deferensany associated cystic fibrosis (E84.-) names E84.-, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Cystic Fibrosis
an autosomal recessive genetic disease of the exocrine glands. it is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator expressed in several organs including the lung, the pancreas, the biliary system, and the sweat glands. cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in airway obstruction; chronic respiratory infections; pancreatic insufficiency; maldigestion; salt depletion; and heat prostration.
Patient EducationClinical
Cystic Fibrosis
Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses, and sex organs. CF causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E84.8 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E84.8Overview
What is the ICD-10 code for cystic fibrosis with other manifestations?
The ICD-10-CM code for cystic fibrosis with other manifestations is E84.8 (sometimes written as E848). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E84.8 (Cystic fibrosis) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report cystic fibrosis with other manifestations on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E84.8 group to?
When cystic fibrosis with other manifestations is the principal diagnosis on an inpatient stay, it groups to MS-DRG 641, 640, with relative weights from 0.7864 to 1.3392 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E84.8 a CC or MCC?
CMS lists E84.8 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 5 closely related codes in its exclusion list.
Can E84.8 be reported with a code from E34.5?
Not as a rule. The Excludes1 note at block E70-E88, which applies to E84.8, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is E84.8?
E84.8 (cystic fibrosis with other manifestations) maps to CMS-HCC Category 277 (Cystic Fibrosis), commonly written as HCC 277, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 110 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 225.
Does E84.8 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, E84.8 adds a risk adjustment factor of about 0.998 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.650 to 3.829 depending on the payment segment). A more severe related category (HCC 276) supersedes it when both are reported. See the full factor table on the HCC 277 category page.
