2026 ICD-10-CM Diagnosis Code E78.2Mixed hyperlipidemia

ICD-10-CM Codes›E00–E89›E70-E88›E78

ICD-10-CM E78.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E78.2 is a billable ICD-10-CM diagnosis code for mixed hyperlipidemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Disorders of lipid metabolism.

Code Identity

ICD-10-CM Code
E78.2
Billable Status
Yes — Valid for Submission
Code Describes
Mixed hyperlipidemia
Short Description
Mixed hyperlipidemia
Same as the full description in the CMS dataset.
Parent Code
E78
Disorders of lipoprotein metabolism and other lipidemias

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE78Disorders of lipoprotein metabolism and other lipidemias
This CodeE78.2Mixed hyperlipidemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Cutaneous xanthoma
  • Diffuse normolipemic plane xanthomatosis
  • Diffuse plane xanthoma due to hyperlipidemia
  • Endogenous hyperlipidemia
  • Eruptive xanthoma
  • Familial type 3 hyperlipoproteinemia
  • Generalized plane xanthoma
  • Hyperlipoproteinemia
  • Mixed hypercholesterolemia and hypertriglyceridemia
  • Mixed hyperlipidemia
  • Mixed hyperlipidemia due to type 1 diabetes mellitus
  • Mixed hyperlipidemia due to type 2 diabetes mellitus
  • Palmar xanthoma
  • Plane xanthoma
  • Primary combined hyperlipidemia
  • Primary genetic hyperlipidemia
  • Primary genetic mixed hyperlipidemia
  • Primary polygenic type IIb combined hyperlipidemia
  • Secondary combined hyperlipidemia
  • Secondary xanthomatous infiltration of the skin
  • Tubero-eruptive xanthoma
  • Tuberous xanthoma
  • Xanthoma diabeticorum
  • Xanthoma disseminatum
  • Xanthoma due to abnormality of lipid metabolism
  • Xanthoma due to lymphedema
  • Xanthoma due to primary combined hyperlipidemia
  • Xanthomatosis
  • Xanthomatosis, familial

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Broad- or floating-betalipoproteinemia
  • Combined hyperlipidemia NOS
  • Elevated cholesterol with elevated triglycerides NEC
  • Fredrickson's hyperlipoproteinemia, type IIb or III
  • Hyperbetalipoproteinemia with prebetalipoproteinemia
  • Hypercholesteremia with endogenous hyperglyceridemia
  • Hyperlipidemia, group C
  • Tubo-eruptive xanthoma
  • Xanthoma tuberosum

Type 1 Excludes

  • cerebrotendinous cholesterosis van Bogaert-Scherer- Epstein E75.5
  • familial combined hyperlipidemia E78.49

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Betalipoproteinemia, broad or floating
    • Broad
      • beta disease
    • Broad- or floating-betalipoproteinemia
    • Cholesterol
      • elevated (high)
        • with elevated (high) triglycerides
    • Cirrhosis, cirrhotic(hepatic) (liver)
      • due to
        • xanthomatosis
    • Cirrhosis, cirrhotic(hepatic) (liver)
      • xanthomatous (biliary)
        • due to xanthomatosis (familial) (metabolic) (primary)
    • Disease, diseased
      • broad
        • beta
    • Dysbetalipoproteinemia(familial)
    • Elevated, elevation
      • cholesterol
        • with high triglycerides
    • Elevated, elevation
      • triglycerides
        • with high cholesterol
    • Findings, abnormal, inconclusive, without diagnosis
      • cholesterol
        • high
          • with high triglycerides
    • Findings, abnormal, inconclusive, without diagnosis
      • triglycerides
        • high
          • with high cholesterol
    • Frederickson's hyperlipoproteinemia, type
      • IIB and III
    • High
      • cholesterol
        • with high triglycerides
    • High
      • triglycerides
        • with high cholesterol
    • Hyperbetalipoproteinemia(familial)
      • with prebetalipoproteinemia
    • Hypercholesterolemia(essential) (primary) (pure)
      • with hyperglyceridemia, endogenous
    • Hyperlipemia, hyperlipidemia
      • combined
    • Hyperlipemia, hyperlipidemia
      • group
        • C
    • Hyperlipemia, hyperlipidemia
      • mixed
    • Hyperlipoproteinemia
      • Fredrickson's type
        • IIb
    • Hyperlipoproteinemia
      • Fredrickson's type
        • III
    • Lipoproteinemia
      • broad-beta
    • Lipoproteinemia
      • floating-beta
    • Xanthelasmatosis(essential)
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • with
        • hyperlipoproteinemia
          • Type III
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • disseminatum (skin)
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • eruptive
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • multiple (skin)
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • tubo-eruptive
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • tuberosum
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • tuberous

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END010
Disorders of lipid metabolism
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hyperlipoproteinemia Type II

    a group of familial disorders characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins (pre-beta lipoproteins).

  • Wolman Disease

    the severe infantile form of inherited lysosomal lipid storage diseases due to deficiency of acid lipase (sterol esterase). it is characterized by the accumulation of neutral lipids, particularly cholesterol esters in leukocytes, fibroblasts, and hepatocytes. it is also known as wolman's xanthomatosis and is an allelic variant of cholesterol ester storage disease.

  • Xanthomatosis

    a condition marked by the development of widespread xanthomas, yellow tumor-like structures filled with lipid deposits. xanthomas can be found in a variety of tissues including the skin; tendons; joints of knees and elbows. xanthomatosis is associated with disturbance of lipid metabolism and formation of foam cells.

  • Xanthomatosis, Cerebrotendinous

    an autosomal recessive lipid storage disorder due to mutation of the gene cyp27a1 encoding a cholestanetriol 26-monooxygenase. it is characterized by large deposits of cholesterol and cholestanol in various tissues resulting in xanthomatous swelling of tendons, early cataract, and progressive neurological symptoms.

  • Mixed Hyperlipidemia

    a dyslipidemia characterized by elevated serum levels of total and low-density cholesterol, and triglycerides.

  • Hyperlipoproteinemia

    an elevated concentration of lipoproteins.

  • Hyperlipoproteinemia, Type I|Familial Essential Hyperlipemia|Familial Hyperchylomicronemia|Hyperlipoproteinemia Type 1A|Lipoprotein Lipase Deficiency

    a genetic disorder of lipoprotein metabolism caused by mutations in the lpl and apolipoprotein (apo) c-ii genes. it is characterized by increased levels of chylomicrons and triglycerides in the blood.

  • Hyperlipoproteinemia, Type I|Familial Essential Hyperlipemia|Familial Hyperchylomicronemia|Hyperlipoproteinemia Type 1A|Lipoprotein Lipase Deficiency

    a genetic condition caused by mutation(s) in the lpl gene, encoding lipoprotein lipase, resulting in reduced activity of the enzyme lipoprotein lipase.

  • Hyperlipoproteinemia, Type II|Type II Hyperlipidemia

    an inheritable form of hyperlipidemia, in which there are excess lipids in the blood.

  • Hyperlipoproteinemia, Type IIa|FH|Familial Hypercholesterolemia|Hyperlipidemia Type IIa|Type IIa Hyperlipidemia

    an autosomal dominant inherited disorder characterized by very high levels of low-density lipoprotein cholesterol (ldl-c) and total cholesterol in the blood. it is usually caused by mutations in the ldlr gene which is located on the short arm of chromosome 19.

  • Hyperlipoproteinemia, Type IIb|Familial Combined Hyperlipidemia|Hyperlipidemia Type IIb|Type IIb Hyperlipidemia|Type IIb Hyperlipoproteinemia

    a disorder of lipoprotein metabolism characterized by high levels of cholesterol and triglycerides in the blood. it is caused by elevation of low density and very low density lipoproteins.

Patient EducationClinical

Cholesterol

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your body needs some cholesterol to make hormones, vitamin D, and substances that help you digest foods. Your body makes all the cholesterol it needs. Cholesterol is also found in foods from animal sources, such as egg yolks, meat, and cheese.

The full article covers:

  • What is cholesterol?
  • What are HDL, LDL, and VLDL?
  • What causes high cholesterol?
  • What can raise my risk of high cholesterol?
  • What other health problems can high cholesterol cause?
  • How is high cholesterol diagnosed?
  • How can I lower my cholesterol?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E78.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
272.2 Mixed hyperlipidemia
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E78.2Overview

Is E78.2 (Disorders of lipoprotein metabolism and other lipidemias) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report mixed hyperlipidemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of E78.2?

Under the General Equivalence Mappings, mixed hyperlipidemia converts to ICD-9-CM 272.2 (mixed hyperlipidemia). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.