2027 ICD-10-CM Diagnosis Code E78.1Pure hyperglyceridemia
ICD-10-CM Codes›E00–E89›E70-E88›E78
- Billable — Valid for Submission
- Chronic Condition
E78.1 is a billable ICD-10-CM diagnosis code for pure hyperglyceridemia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Disorders of lipid metabolism.
E78.1 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 47 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E78.1 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Endogenous hyperlipidemia
- Familial hypertriglyceridemia
- Fredrickson type IV hyperlipoproteinemia
- Hyperlipoproteinemia
- Hypertriglyceridemia
- Primary genetic hyperlipidemia
- Primary hypertriglyceridemia
- Pure hyperglyceridemia
- Secondary hypertriglyceridemia
- Sporadic primary hypertriglyceridemia
- Transient infantile hypertriglyceridemia and hepatosteatosis
- Very low density lipoprotinemia
- Xanthoma due to abnormality of lipid metabolism
- Xanthoma due to primary hypertriglyceridemia
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E78.1: its own notes plus those printed at E78, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Elevated fasting triglycerides
- Endogenous hyperglyceridemia
- Fredrickson's hyperlipoproteinemia, type IV
- Hyperlipidemia, group B
- Hyperprebetalipoproteinemia
- Very-low-density-lipoprotein-type [VLDL] hyperlipoproteinemia
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E78.1, its category, or a range that includes it.
Excludes2 2
These codes carry an Excludes2 note naming E78.1: its condition is not part of those codes, and both may be reported when the patient has both.
- E88.0 Disorders of plasma-protein metabolism, not elsewhere classifieddisorder of lipoprotein metabolism (E78.-) names E78.-, which includes this code
- Block R70-R79 Abnormal findings on examination of blood, without diagnosisabnormalities of lipids (E78.-) names E78.-, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
fasting triglycerides E78.1
triglycerides E78.1
Findings, abnormal, inconclusive, without diagnosis See Also: Abnormal;
high E78.1
triglycerides E78.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Hyperlipoproteinemia Type IV
a hypertriglyceridemia disorder, often with autosomal dominant inheritance. it is characterized by the persistent elevations of plasma triglycerides, endogenously synthesized and contained predominantly in very-low-density lipoproteins (pre-beta lipoproteins). in contrast, the plasma cholesterol and phospholipids usually remain within normal limits.Hypertriglyceridemia
a condition of elevated levels of triglycerides in the blood.
Patient EducationClinical
Triglycerides
Triglycerides are a type of fat. They are the most common type of fat in your body. They come from foods, especially butter, oils, and other fats you eat. Triglycerides also come from extra calories.
The full article covers:
- What are triglycerides?
- What causes high triglycerides?
- How are high triglycerides diagnosed?
- What are the treatments for high triglycerides?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E78.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E78.1Overview
What is the ICD-10 code for pure hyperglyceridemia?
The ICD-10-CM code for pure hyperglyceridemia is E78.1 (sometimes written as E781). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E78.1 (Disorders of lipoprotein metabolism and other lipidemias) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report pure hyperglyceridemia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E78.1 group to?
When pure hyperglyceridemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Can E78.1 be reported with a code from E34.5?
Not as a rule. The Excludes1 note at block E70-E88, which applies to E78.1, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of E78.1?
Under the General Equivalence Mappings, pure hyperglyceridemia converts to ICD-9-CM 272.1 (pure hyperglyceridemia). The mapping is a direct match.
Does E78.1 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage: E78.1 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 47 (Disorders of Lipoid Metabolism).
