2026 ICD-10-CM Diagnosis Code E74.04McArdle disease

ICD-10-CM Codes›E00–E89›E70-E88›E74

ICD-10-CM E74.04
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E74.04 is a billable ICD-10-CM diagnosis code for McArdle disease. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as glycogen storage disease, muscular form. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E74.04
Billable Status
Yes — Valid for Submission
Code Describes
McArdle disease
Short Description
McArdle disease
Same as the full description in the CMS dataset.
Parent Code
E74.0
Glycogen storage disease

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE74Other disorders of carbohydrate metabolism
This CodeE74.04McArdle disease

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Glycogen storage disease, muscular form
  • Glycogen storage disease, type V

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Type V glycogen storage disease

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Deficiency, deficient
      • myophosphorylase
    • Disease, diseased
      • glycogen storage
        • McArdle's
    • Disease, diseased
      • glycogen storage
        • type V
    • Disease, diseased
      • McArdle (-Schmid-Pearson) (glycogenosis V)
    • McArdle(-Schmid)(-Pearson) disease (glycogen storage)
    • Syndrome
      • McArdle (-Schmidt) (-Pearson)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Glycogen Storage Disease Type V

    glycogenosis due to muscle phosphorylase deficiency. characterized by painful cramps following sustained exercise.

  • Glycogen Storage Disease Type VI

    a hepatic glycogen storage disease in which there is an apparent deficiency of hepatic phosphorylase (glycogen phosphorylase, liver form) activity.

  • Glycogen Storage Disease Type VII

    an autosomal recessive glycogen storage disease in which there is deficient expression of 6-phosphofructose 1-kinase in muscle (phosphofructokinase-1, muscle type) resulting in abnormal deposition of glycogen in muscle tissue. these patients have severe congenital muscular dystrophy and are exercise intolerant.

  • Glycogen Storage Disease Type VIII

    an x-linked recessive hepatic glycogen storage disease resulting from lack of expression of phosphorylase-b-kinase activity. symptoms are relatively mild; hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase are present. liver shrinkage occurs in response to glucagon.

  • Glycogen Storage Disease Type V

    an autosomal recessive inherited type of glycogen storage disease caused by deficiency of myophosphorylase. it results in myalgias, muscle cramping and stiffness, and exercise intolerance.

  • Glycogen Storage Disease Type VI

    an autosomal recessive sub-type of glycogen storage disease caused by mutation(s) in the pygl gene, encoding glycogen phosphorylase, liver form. the condition is characterized by mild-moderate hypoglycemia, growth retardation and hepatomegaly.

  • Glycogen Storage Disease Type VII|GSD7|GSDVII|Glycogen Storage Disease VII|Muscle Phosphofructokinase Deficiency|PFKM Deficiency|Phosphofructokinase Deficiency|Phosphofructokinase Deficiency|Tarui Disease

    a rare, autosomal recessive inherited metabolic disorder caused by mutation in the pfkm gene. it results in the deficiency of the m subunit of the phosphofructokinase enzyme. it is characterized by the presence of muscle pain and weakness and sometimes rhabdomyolysis with myoglobinuria, following exercise. affected infants develop muscle weakness. patients with the hemolytic form of this disorder develop hemolytic anemia without signs or symptoms of muscle pain and weakness.

  • PYGL wt Allele|GSD6|Glycogen Phosphorylase L wt Allele|Glycogen Phosphorylase, Liver Gene|Glycogen Storage Disease Type VI Gene|Hers Disease Gene|Phosphorylase, Glycogen, Liver Gene|Phosphorylase, Glycogen; Liver Gene

    human pygl wild-type allele is located in the vicinity of 14q22.1 and is approximately 87 kb in length. this allele, which encodes glycogen phosphorylase, liver form protein, is involved in glycogen catabolism yielding glucose-1-phosphate. mutation of the gene is associated with glycogen storage disease 6.

  • PYGM wt Allele|GSD5|Glycogen Phosphorylase, Muscle Associated wt Allele|Glycogen Phosphorylase, Muscle Gene|Glycogen Storage Disease Type V Gene|McArdle Syndrome Gene|Phosphorylase, Glycogen, Muscle Gene|Phosphorylase, Glycogen; Muscle Gene

    human pygm wild-type allele is located in the vicinity of 11q13.1 and is approximately 14 kb in length. this allele, which encodes glycogen phosphorylase, muscle form protein, plays a role in the catabolism of glycogen. mutations in the gene are associated with glycogen storage disease 5 (mcardle syndrome).

Patient EducationClinical

Carbohydrate Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E74.04 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
271.0 Glycogenosis
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E74.04Overview

Is E74.04 (Glycogen storage disease) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report McArdle disease on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of E74.04?

Under the General Equivalence Mappings, McArdle disease converts to ICD-9-CM 271.0 (glycogenosis). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.