HCC 50: Amyloidosis, Porphyria, and Other Specified Metabolic Disorders ICD-10-CM
CMS-HCC Category 50 (Amyloidosis, Porphyria, and Other Specified Metabolic Disorders) is a payment HCC in the V28 Medicare Advantage risk adjustment model. For payment year 2026 it adds a risk adjustment factor between 0.362 and 0.883 to a beneficiary's RAF score depending on the payment segment (0.648 for a community, non-dual, aged enrollee). 32 ICD-10-CM diagnosis codes map to HCC 50. It sits at the top of its hierarchy: no other condition category supersedes it.
RAF Weight by Payment Segment 7 segments
| Payment Segment | Relative Factor |
|---|---|
| Community, non-dual, aged | 0.648 |
| Community, partial-benefit dual, aged | 0.435 |
| Community, full-benefit dual, aged | 0.555 |
| Community, non-dual, disabled | 0.883 |
| Community, partial-benefit dual, disabled | 0.529 |
| Community, full-benefit dual, disabled | 0.789 |
| Institutional | 0.362 |
A beneficiary is scored in exactly one segment, set by Medicaid (dual) status, aged or disabled entitlement, and residence. Factors are relative weights, not dollar amounts; new-enrollee segments score on demographics only. HCC 50 neither supersedes nor is superseded by any other category, so it always counts alongside unrelated HCCs.
ICD-10-CM Codes That Map to HCC 50 32 codes
- E72.53 Primary hyperoxaluria Non-billable from V24 HCC 23
- E72.530 Primary hyperoxaluria, type 1 new to V28
- E72.538 Other specified primary hyperoxaluria new to V28
- E72.539 Primary hyperoxaluria, unspecified new to V28
- E74.00 Glycogen storage disease, unspecified from V24 HCC 23
- E74.01 von Gierke disease from V24 HCC 23
- E74.03 Cori disease from V24 HCC 23
- E74.04 McArdle disease from V24 HCC 23
- E74.05 Lysosome-associated membrane protein 2 [LAMP2] deficiency from V24 HCC 23
- E74.09 Other glycogen storage disease from V24 HCC 23
- E79.1 Lesch-Nyhan syndrome from V24 HCC 23
- E80.0 Hereditary erythropoietic porphyria from V24 HCC 23
- E80.1 Porphyria cutanea tarda from V24 HCC 23
- E80.20 Unspecified porphyria from V24 HCC 23
- E80.21 Acute intermittent (hepatic) porphyria from V24 HCC 23
- E80.29 Other porphyria from V24 HCC 23
- E80.3 Defects of catalase and peroxidase from V24 HCC 23
- E83.00 Disorder of copper metabolism, unspecified new to V28
- E83.01 Wilson's disease new to V28
- E83.09 Other disorders of copper metabolism new to V28
- E83.31 Familial hypophosphatemia new to V28
- E85.0 Non-neuropathic heredofamilial amyloidosis from V24 HCC 23
- E85.1 Neuropathic heredofamilial amyloidosis from V24 HCC 23
- E85.2 Heredofamilial amyloidosis, unspecified from V24 HCC 23
- E85.3 Secondary systemic amyloidosis from V24 HCC 23
- E85.4 Organ-limited amyloidosis from V24 HCC 23
- E85.81 Light chain (AL) amyloidosis from V24 HCC 23
- E85.82 Wild-type transthyretin-related (ATTR) amyloidosis from V24 HCC 23
- E85.89 Other amyloidosis from V24 HCC 23
- E85.9 Amyloidosis, unspecified from V24 HCC 23
- E88.01 Alpha-1-antitrypsin deficiency from V24 HCC 23
- E88.89 Other specified metabolic disorders from V24 HCC 23
Every code above carries the full HCC 50 weight when documented and reported on a Medicare Advantage encounter. The code link opens its full page with the complete risk adjustment card.
Questions About HCC 50
What is HCC 50 in the CMS-HCC model?
HCC 50 is CMS-HCC Category 50 (Amyloidosis, Porphyria, and Other Specified Metabolic Disorders) in the V28 risk adjustment model. It covers 32 ICD-10-CM diagnosis codes that raise a Medicare Advantage beneficiary's risk score when documented.
What is the RAF weight for HCC 50?
For payment year 2026, HCC 50 adds 0.648 to the RAF score of a community, non-dual, aged beneficiary (living at home, age 65 or over, not also enrolled in Medicaid). The published weights range from 0.362 to 0.883 across the seven payment segments shown above.
Related References
Source: Centers for Medicare & Medicaid Services, Payment Year 2026 risk adjustment mapping and model software releases (CMS-HCC V28), applied to the FY 2026 ICD-10-CM code set. ICD List is not affiliated with CMS.
