HCC 50: Amyloidosis, Porphyria, and Other Specified Metabolic Disorders ICD-10-CM
CMS-HCC Category 50 (Amyloidosis, Porphyria, and Other Specified Metabolic Disorders) is a payment HCC in the V28 Medicare Advantage risk adjustment model. For payment year 2026 it adds a risk adjustment factor between 0.362 and 0.883 to a beneficiary's RAF score depending on the payment segment (0.648 for a community, non-dual, aged enrollee). 32 ICD-10-CM diagnosis codes map to HCC 50. It sits at the top of its hierarchy: no other condition category supersedes it.
RAF Weight by Payment Segment 7 segments
| Payment Segment | Relative Factor |
|---|---|
| Community, non-dual, aged | 0.648 |
| Community, partial-benefit dual, aged | 0.435 |
| Community, full-benefit dual, aged | 0.555 |
| Community, non-dual, disabled | 0.883 |
| Community, partial-benefit dual, disabled | 0.529 |
| Community, full-benefit dual, disabled | 0.789 |
| Institutional | 0.362 |
A beneficiary is scored in exactly one segment, set by Medicaid (dual) status, aged or disabled entitlement, and residence. Factors are relative weights, not dollar amounts; new-enrollee segments score on demographics only. HCC 50 neither supersedes nor is superseded by any other category, so it always counts alongside unrelated HCCs.
ICD-10-CM Codes That Map to HCC 50 32 codes
- E72.53 Primary hyperoxaluria Non-billable from V24 HCC 23
- E72.530 Primary hyperoxaluria, type 1 new to V28
- E72.538 Other specified primary hyperoxaluria new to V28
- E72.539 Primary hyperoxaluria, unspecified new to V28
- E74.00 Glycogen storage disease, unspecified from V24 HCC 23
- E74.01 von Gierke disease from V24 HCC 23
- E74.03 Cori disease from V24 HCC 23
- E74.04 McArdle disease from V24 HCC 23
- E74.05 Lysosome-associated membrane protein 2 [LAMP2] deficiency from V24 HCC 23
- E74.09 Other glycogen storage disease from V24 HCC 23
- E79.1 Lesch-Nyhan syndrome from V24 HCC 23
- E80.0 Hereditary erythropoietic porphyria from V24 HCC 23
- E80.1 Porphyria cutanea tarda from V24 HCC 23
- E80.20 Unspecified porphyria from V24 HCC 23
- E80.21 Acute intermittent (hepatic) porphyria from V24 HCC 23
- E80.29 Other porphyria from V24 HCC 23
- E80.3 Defects of catalase and peroxidase from V24 HCC 23
- E83.00 Disorder of copper metabolism, unspecified new to V28
- E83.01 Wilson's disease new to V28
- E83.09 Other disorders of copper metabolism new to V28
- E83.31 Familial hypophosphatemia new to V28
- E85.0 Non-neuropathic heredofamilial amyloidosis from V24 HCC 23
- E85.1 Neuropathic heredofamilial amyloidosis from V24 HCC 23
- E85.2 Heredofamilial amyloidosis, unspecified from V24 HCC 23
- E85.3 Secondary systemic amyloidosis from V24 HCC 23
- E85.4 Organ-limited amyloidosis from V24 HCC 23
- E85.81 Light chain (AL) amyloidosis from V24 HCC 23
- E85.82 Wild-type transthyretin-related (ATTR) amyloidosis from V24 HCC 23
- E85.89 Other amyloidosis from V24 HCC 23
- E85.9 Amyloidosis, unspecified from V24 HCC 23
- E88.01 Alpha-1-antitrypsin deficiency from V24 HCC 23
- E88.89 Other specified metabolic disorders from V24 HCC 23
Every code above carries the full HCC 50 weight when documented and reported on a Medicare Advantage encounter. The code link opens its full page with the complete risk adjustment card.
Questions About HCC 50
What is HCC 50 in the CMS-HCC model?
HCC 50 is CMS-HCC Category 50 (Amyloidosis, Porphyria, and Other Specified Metabolic Disorders) in the V28 risk adjustment model. It covers 32 ICD-10-CM diagnosis codes that raise a Medicare Advantage beneficiary's risk score when documented.
What is the RAF weight for HCC 50?
For payment year 2026, HCC 50 adds 0.648 to the RAF score of a community, non-dual, aged beneficiary. The published weights range from 0.362 to 0.883 across the seven payment segments shown above.
Related References
Source: Centers for Medicare & Medicaid Services, Payment Year 2026 risk adjustment mapping and model software releases (CMS-HCC V28), applied to the FY 2026 ICD-10-CM code set. ICD List is not affiliated with CMS.
