2027 ICD-10-CM Diagnosis Code E72.548Other secondary hyperoxaluria

ICD-10-CM Codes›E00–E89›E70-E88›E72

ICD-10-CM E72.548
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E72.548 is a billable ICD-10-CM diagnosis code for other secondary hyperoxaluria. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 695 through 696. Coders also document this condition as antifreeze oxalosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E72.548
Billable Status
Yes — Valid for Submission
Code Describes
Other secondary hyperoxaluria
Short Description
Other secondary hyperoxaluria
Same as the full description in the CMS dataset.
Parent Code
E72.54
Secondary hyperoxaluria

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE72Other disorders of amino-acid metabolism
This CodeE72.548Other secondary hyperoxaluria

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Antifreeze oxalosis
  • Secondary oxalosis

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E72.548: its own notes plus those printed at E72.54, E72, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E72.54 Secondary hyperoxaluria applies to 4 codes
From E72 Other disorders of amino-acid metabolism applies to 31 codes
  • disorders of:
  • aromatic amino-acid metabolism (E70.-)
  • branched-chain amino-acid metabolism (E71.0-E71.2)
  • fatty-acid metabolism (E71.3)
  • purine and pyrimidine metabolism (E79.-)
  • gout (M1A.-, M10.-)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E72.548, its category, or a range that includes it.

Excludes1 5

These codes carry an Excludes1 note naming E72.548: they are not reported together with it, unless the two conditions are unrelated.

  • E72.53 Primary hyperoxaluria
    secondary hyperoxaluria (E72.54-) names E72.54-, which includes this code
  • R82.992 Hyperoxaluria
    secondary hyperoxaluria (E72.54-) names E72.54-, which includes this code
  • R79 Other abnormal findings of blood chemistry
    specific findings indicating disorder of amino-acid metabolism (E70-E72) names E70-E72, which includes this code
  • R79.83 Abnormal findings of blood amino-acid level
    disorders of amino-acid metabolism (E70-E72) names E70-E72, which includes this code
  • Block R80-R82 Abnormal findings on examination of urine, without diagnosis
    specific findings indicating disorder of amino-acid metabolism (E70-E72) names E70-E72, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement E72.548 replaces the following previously assigned code(s):

  • R82.992 - Hyperoxaluria
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E72.548Overview

What is the ICD-10 code for other secondary hyperoxaluria?

The ICD-10-CM code for other secondary hyperoxaluria is E72.548 (sometimes written as E72548). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E72.548 (Secondary hyperoxaluria) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other secondary hyperoxaluria on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E72.548 group to?

When other secondary hyperoxaluria is the principal diagnosis on an inpatient stay, it groups to MS-DRG 696, 695, with relative weights from 0.6677 to 1.1136 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E72.548 be reported with a code from E72.53?

Not as a rule. The Excludes1 note at E72.54, which applies to E72.548, lists "primary hyperoxaluria (E72.53-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).