2026 ICD-10-CM Diagnosis Code E72.538Other specified primary hyperoxaluria

ICD-10-CM Codes›E00–E89›E70-E88›E72

ICD-10-CM E72.538
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E72.538 is a billable ICD-10-CM diagnosis code for other specified primary hyperoxaluria. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as primary hyperoxaluria.

Code Identity

ICD-10-CM Code
E72.538
Billable Status
Yes — Valid for Submission
Code Describes
Other specified primary hyperoxaluria
Short Description
Other specified primary hyperoxaluria
Same as the full description in the CMS dataset.
Parent Code
E72.53
Primary hyperoxaluria

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE72Other disorders of amino-acid metabolism
This CodeE72.538Other specified primary hyperoxaluria

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Primary hyperoxaluria
  • Primary hyperoxaluria type III
  • Primary hyperoxaluria, type II

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Primary hyperoxaluria, type 2
  • Primary hyperoxaluria, type 3

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Disorder(of)
      • glycine metabolism
        • hyperoxaluria
          • primary
            • specified type NEC
    • Disorder(of)
      • glycine metabolism
        • hyperoxaluria
          • primary
            • type 2
    • Disorder(of)
      • glycine metabolism
        • hyperoxaluria
          • primary
            • type 3

Clinical InformationClinical

  • AGXT wt Allele|AGT|AGT1|AGXT1|Alanine--Glyoxylate Aminotransferase Gene|Alanine--Glyoxylate and Serine--Pyruvate Aminotransferase Gene|Alanine-Glyoxylate Aminotransferase wt Allele|Glycolicaciduria Gene|Hepatic Peroxisomal Alanine:Glyoxylate Aminotransferase Gene|L-Alanine: Glyoxylate Aminotransferase 1 Gene|Oxalosis I Gene|PH1|Primary Hyperoxaluria Type 1 Gene|SPAT|SPT|Ser-PyrAT|Serine:Pyruvate Aminotransferase Gene|TLH6

    human agxt wild-type allele is located in the vicinity of 2q37.3 and is approximately 12 kb in length. this allele, which encodes alanine-glyoxylate aminotransferase protein, is involved in gluconeogenesis, l-serine metabolism and glyoxylate detoxification. mutations in the gene are associated with primary hyperoxaluria 1.

  • GRHPR wt Allele|GLXR|GLYD|Glycerate-2-Dehydrogenase Gene|Glyoxylate and Hydroxypyruvate Reductase wt Allele|MSTP035|PH2|Primary Hyperoxaluria Type 2 Gene

    human grhpr wild-type allele is located in the vicinity of 9p13.2 and is approximately 14 kb in length. this allele, which encodes glyoxylate reductase/hydroxypyruvate reductase protein, plays a role in hydroxypyruvate and glyoxylate metabolism. mutation of the gene is associated with type ii primary hyperoxaluria.

  • Primary Hyperoxaluria

    a hereditary disorder characterized by excessive oxalate production, leading to hyperoxaluria.

  • Primary Hyperoxaluria Type I

    recessively inherited primary hyperoxaluria due to alanine-glyoxylate aminotransferase (agxt) deficiency.

  • Primary Hyperoxaluria Type II

    recessively inherited primary hyperoxaluria due to glyoxylate reductase/hydroxypyruvate reductase (grhpr) deficiency.

  • Primary Hyperoxaluria Type III

    recessively inherited primary hyperoxaluria due to mitochondrial 4-hydroxy-2-oxoglutarate aldolase (hoga1) gene mutations.

Code History & ChangesHistory

New Code E72.538 was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.

Replacement E72.538 replaces the following previously assigned code(s):

  • E72.53 - Hyperoxaluria
  • E72.53 - Primary hyperoxaluria
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2026CurrentRevised in the current code setEffective October 1, 2025 through September 30, 2026.

Questions About E72.538Overview

Is E72.538 (Primary hyperoxaluria) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other specified primary hyperoxaluria on HIPAA-covered claims from October 1, 2025 through September 30, 2026.