2026 ICD-10-CM Diagnosis Code D80.7Transient hypogammaglobulinemia of infancy

ICD-10-CM Codes›D50–D89›D80-D89›D80

ICD-10-CM D80.7
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D80.7 is a billable ICD-10-CM diagnosis code for transient hypogammaglobulinemia of infancy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 44 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

D80.7 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 47 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 47, ESRD (V21) category 47, ESRD (V24) category 47, and RxHCC Part D (V08) category 99 for payment year 2026.

Code Identity

ICD-10-CM Code
D80.7
Billable Status
Yes — Valid for Submission
Code Describes
Transient hypogammaglobulinemia of infancy
Short Description
Transient hypogammaglobulinemia of infancy
Same as the full description in the CMS dataset.
Parent Code
D80
Immunodeficiency with predominantly antibody defects

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD80Immunodeficiency with predominantly antibody defects
This CodeD80.7Transient hypogammaglobulinemia of infancy

Medicare Risk Adjustment (HCC)Billing

D80.7 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 47
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 47 · ESRD (V21): HCC 47 · ESRD (V24): HCC 47
ESRD V21 weights: 0.097 dialysis, 0.549–0.688 functioning graft · ESRD V24 weights: 0.078 dialysis, 0.523–0.803 functioning graft
Part D (RxHCC)
RxHCC 99 — Immune Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Transient hypogammaglobulinemia of infancy

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D80.7 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
279.09 Humoral immunity def NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D80.7Overview

What is the ICD-10 code for transient hypogammaglobulinemia of infancy?

The ICD-10-CM code for transient hypogammaglobulinemia of infancy is D80.7 (sometimes written as D807). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Is D80.7 (Immunodeficiency with predominantly antibody defects) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report transient hypogammaglobulinemia of infancy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D80.7 group to?

When transient hypogammaglobulinemia of infancy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

Is D80.7 a CC or MCC?

CMS lists D80.7 as a CC (complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 44 closely related codes in its exclusion list.

What is the ICD-9 equivalent of D80.7?

Under the General Equivalence Mappings, transient hypogammaglobulinemia of infancy converts to ICD-9-CM 279.09 (humoral immunity def NEC). The mapping is approximate, so confirm the match fits the documentation.

Does D80.7 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. D80.7 mapped to HCC 47 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 47 (Disorders of Immunity), ESRD (V21) category 47 (Disorders of Immunity), ESRD (V24) category 47 (Disorders of Immunity), and RxHCC Part D (V08) category 99 (Immune Disorders).