2026 ICD-10-CM Diagnosis Code D80.2Selective deficiency of immunoglobulin A [IgA]
ICD-10-CM Codes›D50–D89›D80-D89›D80
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 115
- Chronic Condition
D80.2 is a billable ICD-10-CM diagnosis code for selective deficiency of immunoglobulin A [IgA]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 46 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.
For Medicare Advantage risk adjustment, D80.2 maps to CMS-HCC Category 115 (Specified Immunodeficiencies and White Blood Cell Disorders) under the V28 model, adding a risk factor of about 0.565 for a community, non-dual, aged beneficiary in payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D80.2 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2026.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Alpha globulin level outside reference range
- Chromosome 22 abnormalities with hypogammaglobulinemia
- Deficiency of immunoglobulin A with immunoglobulin G subclass deficiency
- Humoral immune defect
- Hypoalphaglobulinemia
- Immune defect
- Immunoglobulin A deficiency
- Immunoglobulin A1 deficiency
- Immunoglobulin A2 deficiency
- Immunoglobulin G subclass deficiency
- Immunoglobulin heavy chain deficiency
- Monosomy 22 and absence of immunoglobulin A
- Selective immunoglobulin A deficiency
- Selective immunoglobulin M and immunoglobulin A deficiency
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
The full article covers:
- What is the immune system?
- What are the parts of the immune system?
- How does the immune system work?
- What are the types of immunity?
- What can go wrong with the immune system?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D80.2 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D80.2Overview
What is the ICD-10 code for selective deficiency of immunoglobulin A [IgA]?
The ICD-10-CM code for selective deficiency of immunoglobulin A [IgA] is D80.2 (sometimes written as D802). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is D80.2 (Immunodeficiency with predominantly antibody defects) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report selective deficiency of immunoglobulin A [IgA] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D80.2 group to?
When selective deficiency of immunoglobulin A [IgA] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.
Is D80.2 a CC or MCC?
CMS lists D80.2 as a CC (complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 46 closely related codes in its exclusion list.
What is the ICD-9 equivalent of D80.2?
Under the General Equivalence Mappings, selective deficiency of immunoglobulin A [IgA] converts to ICD-9-CM 279.01 (selective iga immunodef). The mapping is a direct match.
What HCC is D80.2?
D80.2 (selective deficiency of immunoglobulin A [IgA]) maps to CMS-HCC Category 115 (Specified Immunodeficiencies and White Blood Cell Disorders), commonly written as HCC 115, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2026. It mapped to HCC 47 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 99.
Does D80.2 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D80.2 adds a risk adjustment factor of about 0.565 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.302 to 0.692 depending on the payment segment). A more severe related category (HCC 114) supersedes it when both are reported. See the full factor table on the HCC 115 category page.
