2026 ICD-10-CM Diagnosis Code D80.2Selective deficiency of immunoglobulin A [IgA]

ICD-10-CM Codes›D50–D89›D80-D89›D80

ICD-10-CM D80.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D80.2 is a billable ICD-10-CM diagnosis code for selective deficiency of immunoglobulin A [IgA]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D80.2
Billable Status
Yes — Valid for Submission
Code Describes
Selective deficiency of immunoglobulin A [IgA]
Short Description
Selective deficiency of immunoglobulin A [IgA]
Same as the full description in the CMS dataset.
Parent Code
D80
Immunodeficiency with predominantly antibody defects

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD80Immunodeficiency with predominantly antibody defects
This CodeD80.2Selective deficiency of immunoglobulin A [IgA]

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Alpha globulin level outside reference range
  • Chromosome 22 abnormalities with hypogammaglobulinemia
  • Deficiency of immunoglobulin A with immunoglobulin G subclass deficiency
  • Humoral immune defect
  • Hypoalphaglobulinemia
  • Immune defect
  • Immunoglobulin A deficiency
  • Immunoglobulin A1 deficiency
  • Immunoglobulin A2 deficiency
  • Immunoglobulin G subclass deficiency
  • Immunoglobulin heavy chain deficiency
  • Monosomy 22 and absence of immunoglobulin A
  • Selective immunoglobulin A deficiency
  • Selective immunoglobulin M and immunoglobulin A deficiency

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Absence(of) (organ or part) (complete or partial)
      • immunoglobulin, isolated NEC
        • IgA
    • Deficiency, deficient
      • immunity
        • IgA (secretory)
    • Deficiency, deficient
      • immunoglobulin, selective
        • A (IgA)
    • Immunodeficiency
      • selective, immunoglobulin
        • A (IgA)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D80.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
279.01 Selective iga immunodef
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D80.2Overview

Is D80.2 (Immunodeficiency with predominantly antibody defects) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report selective deficiency of immunoglobulin A [IgA] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D80.2 group to?

When selective deficiency of immunoglobulin A [IgA] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D80.2?

Under the General Equivalence Mappings, selective deficiency of immunoglobulin A [IgA] converts to ICD-9-CM 279.01 (selective iga immunodef). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.