2026 ICD-10-CM Diagnosis Code D69.49Other primary thrombocytopenia

ICD-10-CM Codes›D50–D89›D65-D69›D69

ICD-10-CM D69.49
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D69.49 is a billable ICD-10-CM diagnosis code for other primary thrombocytopenia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coagulation and hemorrhagic disorders.

Code Identity

ICD-10-CM Code
D69.49
Billable Status
Yes — Valid for Submission
Code Describes
Other primary thrombocytopenia
Short Description
Other primary thrombocytopenia
Same as the full description in the CMS dataset.
Parent Code
D69.4
Other primary thrombocytopenia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD65-D69Coagulation defects, purpura and other hemorrhagic conditions
CategoryD69Purpura and other hemorrhagic conditions
This CodeD69.49Other primary thrombocytopenia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Amegakaryocytic thrombocytopenia
  • Autoimmune hemolytic anemia, autoimmune thrombocytopenia, primary immunodeficiency syndrome
  • Congenital cutaneous angiomatosis
  • Decreased megakaryocyte production
  • Kasabach-Merritt syndrome
  • Mediterranean thrombocytopenia
  • Megakaryocytic aplasia
  • Megakaryocytic thrombocytopenia
  • Primary thrombocytopenia
  • Thrombocytopenia due to defective platelet production
  • Thrombocytopenia due to diminished platelet production
  • Thrombocytopenic purpura

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Megakaryocytic hypoplasia
  • Primary thrombocytopenia NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hypoplasia, hypoplastic
      • bone NOS
        • marrow
          • megakaryocytic
    • Hypoplasia, hypoplastic
      • megakaryocytic
    • Purpura
      • primary
    • Purpura
      • thrombocytopenic
    • Purpura
      • thrombopenic
    • Thrombocytopenia, thrombocytopenic
      • primary NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD006
Coagulation and hemorrhagic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Acquired Thrombotic Thrombocytopenic Purpura|Acquired ADAMTS13 Deficiency|Acquired TTP

    thrombotic thrombocytopenic purpura for which the cause is not present at birth.

  • Congenital Thrombotic Thrombocytopenic Purpura|Congenital ADAMTS-13 Deficiency|Congenital ADAMTS13 Deficiency|Congenital TTP

    thrombotic thrombocytopenic purpura for which the cause is present from birth.

  • Grade 3 Thrombotic Thrombocytopenic Purpura, CTCAE|Grade 3 Thrombotic thrombocytopenic purpura

    laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)

  • Grade 4 Thrombotic Thrombocytopenic Purpura, CTCAE|Grade 4 Thrombotic thrombocytopenic purpura

    life-threatening consequences, (e.g., cns hemorrhage or thrombosis/embolism or renal failure)

  • Grade 5 Thrombotic Thrombocytopenic Purpura, CTCAE|Grade 5 Thrombotic thrombocytopenic purpura

    death

  • Primary Immune Thrombocytopenia|ITP|ITP|ITP|ITP|Idiopathic Thrombocytopenia|Idiopathic Thrombocytopenia Purpura|Idiopathic Thrombocytopenic Purpura|Idiopathic Thrombocytopenic Purpura|Idiopathic Thrombocytopenic Purpura|Idiopathic Thrombocytopenic Purpura|Immune Thrombocytopenia|Immune Thrombocytopenic Purpura|Immune thrombocytopenic purpura|idiopathic thrombocytopenic purpura|immune thrombocytopenic purpura

    acquired thrombocytopenia of unknown cause, characterized by immune-mediated destruction of normal platelets. it affects both children and adults. it manifests with petechiae, purpura, and overt bleeding. based upon the duration of the disease, it is classified as newly diagnosed (from diagnosis until 3 months), persistent (3-12 months), and chronic (lasting for more than 12 months).

  • Thrombocytopenic Purpura

    purpura associated with a reduction in circulating blood platelets which can result from a variety of factors.

  • Thrombotic Thrombocytopenic Purpura, CTCAE|Thrombotic Thrombocytopenic Purpura|Thrombotic thrombocytopenic purpura

    a disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. it is an acute or subacute condition.

  • Thrombotic Thrombocytopenic Purpura|Moschowitz Disease|TTP|TTP|Thrombotic thrombocytopenic purpura

    a coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of adamts13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction.

  • Acquired Amegakaryocytic Thrombocytopenia|AAMT|AAT|AATP|Acquired Amegakaryocytic Thrombocytopenic Purpura

    a rare bone marrow disorder characterized by a marked decrease or complete absence of megakaryocytes with preservation of all other hematopoietic cell lineages. causes include toxins, viruses, drugs, and humoral and cell-mediated suppression of megakaryocytopoeisis. it usually presents with bleeding, severe thrombocytopenia, and absence of splenomegaly. it is often misdiagnosed as immune thrombocytopenic purpura (itp).

  • Thrombotic Thrombocytopenic Purpura, CTCAE|Thrombotic Thrombocytopenic Purpura|Thrombotic thrombocytopenic purpura

    a disorder characterized by a deficiency of adamts13 and the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. it is an acute or subacute condition.

Patient EducationClinical

Platelet Disorders

Platelets, also known as thrombocytes, are blood cells. They form in your bone marrow, a sponge-like tissue in your bones. Platelets play a major role in blood clotting. Normally, when one of your blood vessels is injured, you start to bleed.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D69.49 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
287.30 Prim thrombocytopen NOS
Approximate The match is approximate rather than exact.
ICD-9-CM
287.39 Prim thrombocytopen NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D69.49Overview

Is D69.49 (Other primary thrombocytopenia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other primary thrombocytopenia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of D69.49?

Under the General Equivalence Mappings, other primary thrombocytopenia converts to ICD-9-CM 287.30 (prim thrombocytopen NOS) and 287.39 (prim thrombocytopen NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.