2026 ICD-10-CM Diagnosis Code D59.4Other nonautoimmune hemolytic anemias

ICD-10-CM Codes›D50–D89›D55-D59›D59

ICD-10-CM D59.4
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D59.4 is a billable ICD-10-CM diagnosis code for other nonautoimmune hemolytic anemias. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.

Code Identity

ICD-10-CM Code
D59.4
Billable Status
Yes — Valid for Submission
Code Describes
Other nonautoimmune hemolytic anemias
Short Description
Other nonautoimmune hemolytic anemias
Same as the full description in the CMS dataset.
Parent Code
D59
Acquired hemolytic anemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD59Acquired hemolytic anemia
This CodeD59.4Other nonautoimmune hemolytic anemias

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Anemia caused by oxygen
  • Anemia due to mechanical damage
  • Babesiosis
  • Disease caused by Babesiidae
  • Hematologic complication of procedure
  • Hemolytic anemia caused by Bartonella
  • Hemolytic anemia caused by Clostridium welchii
  • Hemolytic anemia caused by hyperbaric oxygen
  • Hemolytic anemia due to babesiosis
  • Hemolytic anemia due to infection
  • Hemolytic anemia due to malaria
  • Infection caused by Clostridium perfringens
  • Intracorpuscular hemolytic anemia
  • Intraerythrocytic parasitosis by Nuttallia
  • Mechanical hemolysis following insertion of prosthetic heart valve
  • Mechanical hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Non-autoimmune hemolytic anemia
  • Polyagglutinable erythrocyte syndrome
  • Toxic hemolytic anemia
  • Traumatic cardiac hemolytic anemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Mechanical hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Toxic hemolytic anemia

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • acquired
          • infectious
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • acquired
          • toxic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • due to
          • cardiac conditions
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • due to
          • presence of shunt or other internal prosthetic device
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • mechanical
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • microangiopathic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • nonautoimmune
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • secondary
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • symptomatic
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • toxic
    • Disease, diseased
      • nonautoimmune hemolytic
    • Nonautoimmune hemolytic anemia
    • Syndrome
      • erythrocyte fragmentation

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Babesiosis

    a group of tick-borne diseases of mammals including zoonoses in humans. they are caused by protozoa of the genus babesia, which parasitize erythrocytes, producing hemolysis. in the u.s., the organism's natural host is mice and transmission is by the deer tick ixodes scapularis.

  • Babesiosis

    a parasitic infection caused by babesia. it is transmitted by ticks and infects the red blood cells. signs and symptoms include fever, fatigue and hemolytic anemia.

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D59.4 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
283.10 Nonauto hem anemia NOS
Approximate The match is approximate rather than exact.
ICD-9-CM
283.19 Oth nonauto hem anemia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D59.4Overview

Is D59.4 (Acquired hemolytic anemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other nonautoimmune hemolytic anemias on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D59.4 group to?

When other nonautoimmune hemolytic anemias is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D59.4?

Under the General Equivalence Mappings, other nonautoimmune hemolytic anemias converts to ICD-9-CM 283.10 (nonauto hem anemia NOS) and 283.19 (oth nonauto hem anemia). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.