2026 ICD-10-CM Diagnosis Code D48.19Other specified neoplasm of uncertain behavior of connective and other soft tissue

AHRQ’s CCSR groups this code into broader clinical categories.

• Hemangioblastoma

  a benign tumor of the nervous system that may occur sporadically or in association with von hippel-lindau disease. it accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. cerebellar hemangioblastomas usually present in the third decade with intracranial hypertension, and ataxia. (from devita et al., cancer: principles and practice of oncology, 5th ed, pp2071-2)

• Myofibromatosis

  a condition characterized by multiple formations of myofibromas (leiomyoma).

• Chondromatosis

  multiple formation of chondromas. (dorland, 27th ed)

• Chondromatosis, Synovial

  rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. some of the metaplastic foci can become detached producing loose bodies. when the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.

• Hemangioendothelioma

  a neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). they affect men and women about equally and rarely develop in childhood. (from stedman, 25th ed; holland et al., cancer medicine, 3d ed, p1866)

• Hemangioendothelioma, Epithelioid

  a tumor of medium-to-large veins, composed of plump-to-spindled endothelial cells that bulge into vascular spaces in a tombstone-like fashion. these tumors are thought to have borderline aggression, where one-third develop local recurrences, but only rarely metastasize. it is unclear whether the epithelioid hemangioendothelioma is truly neoplastic or an exuberant tissue reaction, nor is it clear if this is equivalent to kimura's disease (see angiolymphoid hyperplasia with eosinophilia). (segen, dictionary of modern medicine, 1992)

• Leiomyoma

  a benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. they rarely occur outside of the uterus and the gastrointestinal tract but can occur in the skin and subcutaneous tissue, probably arising from the smooth muscle of small blood vessels in these tissues.

• Angiolymphoid Hyperplasia with Eosinophilia

  solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells.

• Angiomyxoma

  a benign soft tissue neoplasm characterized by the presence of neoplastic spindle and stellate cells, and vascular proliferation in a myxoid stroma.

• Deep (Aggressive) Angiomyxoma|Aggressive Angiomyxoma|Aggressive angiomyxoma|Deep "Aggressive" Angiomyxoma|Deep Angiomyxoma

  a locally infiltrating, non-metastasizing angiomyxoma arising from the pelviperineal region. it may recur following resection

• Paratesticular Deep (Aggressive) Angiomyxoma|Paratesticular Deep "Aggressive" Angiomyxoma

  a locally infiltrating, non-metastasizing angiomyxoma that arises from the paratesticular region.

• Superficial Angiomyxoma

  an angiomyxoma arising from the dermis or subcutaneous tissues. it may recur following resection.

• Vaginal Deep (Aggressive) Angiomyxoma|Vaginal Aggressive Angiomyxoma|Vaginal Deep "Aggressive" Angiomyxoma|Vaginal Deep Angiomyxoma

  a locally infiltrating, non-metastasizing vaginal angiomyxoma. it may recur following resection.

• Vulvar Angiomyxoma

  a deep or superficial angiomyxoma of the vulva. it may recur following resection.

• Vulvar Deep (Aggressive) Angiomyxoma|Vulvar Aggressive Angiomyxoma|Vulvar Deep "Aggressive" Angiomyxoma|Vulvar Deep Angiomyxoma

  a locally infiltrating, non-metastasizing vulvar angiomyxoma. it may recur following resection.

• Vulvar Superficial Angiomyxoma

  a vulvar angiomyxoma arising from the dermis or subcutaneous tissues. it may recur following resection.

• Fibrocartilaginous Mesenchymoma

  a very rare, locally aggressive neoplasm arising from the bones, usually from the metaphysis of long tubular bones. it is composed of spindle cells, hyaline cartilage nodules, and trabeculae of bone. it may recur locally, but no metastases have been reported.

Anatomical sites in the Table of Neoplasms that reference this code family.