2027 ICD-10-CM Diagnosis Code D48.19Other specified neoplasm of uncertain behavior of connective and other soft tissue
ICD-10-CM Codes›C00–D49›D37-D48›D48
- Billable — Valid for Submission
- Not Chronic
D48.19 is a billable ICD-10-CM diagnosis code for other specified neoplasm of uncertain behavior of connective and other soft tissue. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 564 through 566. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Aggressive angiomyxoma
- Aggressive fibromatosis
- Aggressive fibromatosis of abdomen
- Aggressive fibromatosis of abdominal wall
- Alport syndrome
- Alport syndrome X-linked
- Angiomatoid fibrous histiocytoma
- Angiomyxoma
- Atypical fibrous histiocytoma of soft tissue
- Atypical fibroxanthoma - spindle cell type
- Atypical fibroxanthoma of skin
- Atypical lipoma of soft tissue
- Chondromatosis
- Chondromatosis of synovium of hip joint
- Chondromatosis of synovium of knee joint
- Chondromatosis of synovium of temporomandibular joint
- Collagen IV nephropathy
- Composite hemangioendothelioma
- Congenital nephritis
- Desmoplastic fibroma
- Desmoplastic fibroma of lower limb
- Desmoplastic fibroma of upper limb
- Epithelioid hemangioendothelioma
- Extragastrointestinal stromal tumor of peritoneum
- Fat-forming solitary fibrous tumor
- Fibrocartilaginous mesenchymoma
- Giant cell tumor of soft parts
- Giant cell tumor of synovium and/or tendon sheath
- Giant cell-rich solitary fibrous tumor
- Hemangioblastoma
- Hemangioblastoma of peripheral nerve
- Hemangioblastoma of soft tissue
- Hemangioendothelioma
- Hemosiderotic fibrolipomatous tumor
- Kaposiform hemangioendothelioma
- Lesion of joint capsule of pelvic region
- Lipofibromatosis
- Lymphangiomyomatosis of connective tissue
- Mass of hip joint
- Myofibromatosis
- Neoplasm of coccygeal body
- Neoplasm of diaphragm
- Neoplasm of great vessels
- Neoplasm of muscle of abdomen
- Neoplasm of muscle of buttock
- Neoplasm of muscle of face
- Neoplasm of muscle of head
- Neoplasm of muscle of hip
- Neoplasm of muscle of inguinal region
- Neoplasm of muscle of neck
- Neoplasm of muscle of pelvis
- Neoplasm of muscle of perineum
- Neoplasm of muscle of shoulder
- Neoplasm of muscle of thorax
- Neoplasm of soft tissues of inguinal region
- Neoplasm of uncertain behavior of axilla
- Neoplasm of uncertain behavior of blood vessel
- Neoplasm of uncertain behavior of coccygeal body
- Neoplasm of uncertain behavior of diaphragm
- Neoplasm of uncertain behavior of great vessels
- Neoplasm of uncertain behavior of inguinal region
- Neoplasm of uncertain behavior of muscle
- Neoplasm of uncertain behavior of muscle of abdomen
- Neoplasm of uncertain behavior of muscle of buttock
- Neoplasm of uncertain behavior of muscle of face
- Neoplasm of uncertain behavior of muscle of head
- Neoplasm of uncertain behavior of muscle of hip
- Neoplasm of uncertain behavior of muscle of inguinal region
- Neoplasm of uncertain behavior of muscle of lower limb
- Neoplasm of uncertain behavior of muscle of neck
- Neoplasm of uncertain behavior of muscle of pelvis
- Neoplasm of uncertain behavior of muscle of perineum
- Neoplasm of uncertain behavior of muscle of shoulder
- Neoplasm of uncertain behavior of muscle of thorax
- Neoplasm of uncertain behavior of muscle of trunk
- Neoplasm of uncertain behavior of muscle of upper limb
- Neoplasm of uncertain behavior of paraganglia
- Neoplasm of uncertain behavior of smooth muscle
- Neoplasm of uncertain behavior of soft tissue of hand
- Neoplasm of uncertain behavior of soft tissues
- Neoplasm of uncertain behavior of soft tissues of abdomen
- Neoplasm of uncertain behavior of soft tissues of axilla
- Neoplasm of uncertain behavior of soft tissues of buttock
- Neoplasm of uncertain behavior of soft tissues of face
- Neoplasm of uncertain behavior of soft tissues of head
- Neoplasm of uncertain behavior of soft tissues of hip
- Neoplasm of uncertain behavior of soft tissues of inguinal region
- Neoplasm of uncertain behavior of soft tissues of lower limb
- Neoplasm of uncertain behavior of soft tissues of neck
- Neoplasm of uncertain behavior of soft tissues of pelvis
- Neoplasm of uncertain behavior of soft tissues of perineum
- Neoplasm of uncertain behavior of soft tissues of shoulder
- Neoplasm of uncertain behavior of soft tissues of thorax
- Neoplasm of uncertain behavior of soft tissues of trunk
- Neoplasm of uncertain behavior of soft tissues of upper limb
- Neuroendocrine composite hemangioendothelioma
- Pleomorphic hyalinizing angiectatic tumor of soft tissue
- Plexiform fibrohistiocytic tumor
- Pseudomyogenic epithelioid sarcoma-like hemangioendothelioma
- Retiform hemangioendothelioma
- Solitary fibrous tumor
- Spindle cell hemangioma
- Superficial angiomyxoma
- Superficial CD34-positive fibroblastic tumor
- Synovial chondromatosis
- X-linked diffuse leiomyomatosis with Alport syndrome
- X-linked sensorineural hearing loss
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D48.19: its own notes plus those printed at D48.1, D48, block D37-D48, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- neurofibromatosis (nonmalignant) (Q85.0-)
- neoplasms of unspecified behavior (D49.-)
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D48.19, its category, or a range that includes it.
Excludes1 5
These codes carry an Excludes1 note naming D48.19: they are not reported together with it, unless the two conditions are unrelated.
- D37 Neoplasm of uncertain behavior of oral cavity and digestive organsstromal tumors of uncertain behavior of digestive system (D48.1-) names D48.1-, which includes this code
- D48.0 Neoplasm of uncertain behavior of bone and articular cartilageneoplasm of uncertain behavior of cartilage of ear (D48.1-) names D48.1-, which includes this code
- D48.0 Neoplasm of uncertain behavior of bone and articular cartilageneoplasm of uncertain behavior of connective tissue of eyelid (D48.1-) names D48.1-, which includes this code
- D48.0 Neoplasm of uncertain behavior of bone and articular cartilageneoplasm of uncertain behavior of synovia (D48.1-) names D48.1-, which includes this code
- D48.7 Neoplasm of uncertain behavior of other specified sitesneoplasm of uncertain behavior of connective tissue (D48.1-) names D48.1-, which includes this code
Excludes2 1
These codes carry an Excludes2 note naming D48.19: its condition is not part of those codes, and both may be reported when the patient has both.
Code First 1
These codes say to code first a condition named in the note, and D48.19 is one of the conditions named.
Notes 1
These notes mention D48.19.
- Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesCategories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. names D48, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Myofibromatosis D48.19
Tumor See Also: Neoplasm, unspecified behavior, by site;
gastric D48.19
uncertain behavior D48.19
uncertain behavior D48.19
uncertain behavior D48.19
uncertain behavior D48.19
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Myofibromatosis
a condition characterized by multiple formations of myofibromas (leiomyoma).
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| abdomen, abdominal › wall [See Also: Neoplasm, abdomen, wall, skin] › connective tissue | C49.4 | C79.8 | – | D21.4 | D48.1 | D49.2 |
| adipose tissue [See Also: Neoplasm, connective tissue] | C49.4 | C79.89 | – | D21.9 | D48.1 | D49.2 |
| aorta (thoracic) | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| aorta (thoracic) › abdominal | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| aponeurosis | C49.9 | C79.89 | – | D21.9 | D48.1 | D49.2 |
| aponeurosis › palmar | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| aponeurosis › plantar | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| carotid (artery) | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › auricular | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › ear (external) | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › eyelid | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › pinna | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| coccygeal › body or glomus | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC | C49.9 | C79.89 | – | D21.9 | D48.1 | D49.2 |
| connective tissue NEC › abdomen | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › abdominal wall | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › ankle | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › antecubital fossa or space | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › arm | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › auricle (ear) | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › axilla | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › back | C49.6 | C79.89 | – | D21.6 | D48.1 | D49.2 |
| connective tissue NEC › buttock | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › calf | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › cervical region | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › cheek | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › chest (wall) | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › chin | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › diaphragm | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › ear (external) | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › elbow | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › extrarectal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › extremity | C49.9 | C79.89 | – | D21.9 | D48.1 | D49.2 |
| connective tissue NEC › extremity › lower | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › extremity › upper | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › eyelid | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › face | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › finger | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › flank | C49.6 | C79.89 | – | D21.6 | D48.1 | D49.2 |
| connective tissue NEC › foot | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › forearm | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › forehead | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › gastric | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › gastrointestinal | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › gluteal region | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › great vessels NEC | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › groin | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › hand | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › head | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › heel | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › hip | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › hypochondrium | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › iliopsoas muscle | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › infraclavicular region | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › inguinal (canal) (region) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › intestinal | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › intrathoracic | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › ischiorectal fossa | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › jaw | C03.9 | C79.89 | D00.03 | D10.39 | D48.1 | D49.0 |
| connective tissue NEC › knee | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › leg | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › limb NEC | C49.9 | C79.89 | – | D21.9 | D48.1 | D49.2 |
| connective tissue NEC › limb NEC › lower | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › limb NEC › upper | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › nates | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › neck | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › orbit | C69.6 | C79.49 | D09.2 | D31.6 | D48.1 | D49.89 |
| connective tissue NEC › pararectal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › para-urethral | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › paravaginal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › pelvis (floor) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › pelvo-abdominal | C49.8 | C79.89 | – | D21.6 | D48.1 | D49.2 |
| connective tissue NEC › perineum | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › perirectal (tissue) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › periurethral (tissue) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › popliteal fossa or space | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › presacral | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › psoas muscle | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › pterygoid fossa | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › rectovaginal septum or wall | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › rectovesical | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › sacrococcygeal region | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › scalp | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › scapular region | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › shoulder | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › stomach | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › submental | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › supraclavicular region | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › temple | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › temporal region | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| connective tissue NEC › thigh | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › thoracic (duct) (wall) | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › thorax | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › thumb | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| connective tissue NEC › toe | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| connective tissue NEC › trunk | C49.6 | C79.89 | – | D21.6 | D48.1 | D49.2 |
| connective tissue NEC › umbilicus | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| connective tissue NEC › vesicorectal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › wrist | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| diaphragm | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| ear (external) [See Also: Neoplasm, skin, ear] › cartilage | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| eyelid (lower) (skin) (upper) › cartilage | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| fascia [See Also: Neoplasm, connective tissue] › palmar | C49.1 | C79.89 | – | D21.1 | D48.1 | D49.2 |
| fascia [See Also: Neoplasm, connective tissue] › plantar | C49.2 | C79.89 | – | D21.2 | D48.1 | D49.2 |
| fossa (of) › pterygoid | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| glomus › coccygeal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| great vessels NEC | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| lymph, lymphatic channel NEC | C49.9 | C79.89 | – | D21.9 | D48.1 | D49.2 |
| lymph, lymphatic channel NEC › vessel [See Also: Neoplasm, connective tissue] | C49.9 | C79.89 | – | D21.9 | D48.1 | D49.2 |
| pterygoid fossa | C49.0 | C79.89 | – | D21.0 | D48.1 | D49.2 |
| thorax, thoracic (cavity) (organs NEC) › duct | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| vena cava (abdominal) (inferior) | C49.4 | C79.89 | – | D21.4 | D48.1 | D49.2 |
| vena cava (abdominal) (inferior) › superior | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
Code History & ChangesHistory
Replacement D48.19 replaces the following previously assigned code(s):
- D48.1 - Neoplasm of uncertain behavior of connctv/soft tiss
Questions About D48.19Overview
Is D48.19 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other specified neoplasm of uncertain behavior of connective and other soft tissue on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D48.19 group to?
When other specified neoplasm of uncertain behavior of connective and other soft tissue is the principal diagnosis on an inpatient stay, it groups to MS-DRG 564, 566, 565, with relative weights from 0.7374 to 1.4909 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D48.19 be reported with D48.0?
Not as a rule. The Excludes1 note at D48.1, which applies to D48.19, lists "neoplasm of uncertain behavior of articular cartilage (D48.0)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).