ICD-10 Diagnosis Code C49.9

Malignant neoplasm of connective and soft tissue, unsp

Diagnosis Code C49.9

ICD-10: C49.9
Short Description: Malignant neoplasm of connective and soft tissue, unsp
Long Description: Malignant neoplasm of connective and soft tissue, unspecified
This is the 2018 version of the ICD-10-CM diagnosis code C49.9

Valid for Submission
The code C49.9 is valid for submission for HIPAA-covered transactions.

Code Classification
  • Neoplasms (C00–D48)
    • Malignant neoplasms of mesothelial and soft tissue (C45-C49)
      • Malignant neoplasm of other connective and soft tissue (C49)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code C49.9 is grouped in the following Diagnostic Related Group(s) (MS-DRG V35.0)


Convert to ICD-9 Additional informationCallout TooltipGeneral Equivalence Map
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Adipocytic liposarcoma
  • Alveolar rhabdomyosarcoma
  • Alveolar soft part sarcoma
  • Angiosarcoma
  • Botryoid rhabdomyosarcoma
  • Cutaneous fibrosarcoma
  • Cutaneous leiomyosarcoma
  • Cutaneous leiomyosarcoma with granular cell change
  • Dedifferentiated liposarcoma
  • Embryonal rhabdomyosarcoma
  • Epithelioid leiomyosarcoma of skin
  • Ewing's sarcoma of soft tissue
  • Extraskeletal osteosarcoma
  • Fibrosarcoma of connective tissue
  • Giant cell malignant fibrous histiocytoma of skin
  • Infantile fibrosarcoma
  • Inflammatory malignant fibrous histiocytoma of skin
  • Intravascular angiosarcoma
  • Leiomyosarcoma
  • Leiomyosarcoma of connective tissue
  • Liposarcoma
  • Liposarcoma of connective tissue
  • Local recurrence of malignant tumor of soft tissue
  • Low-grade fibromyxoid sarcoma
  • Lymphangiosarcoma
  • Malignant fibrohistiocytic tumor of skin
  • Malignant fibromatous neoplasm
  • Malignant fibrous histiocytoma
  • Malignant fibrous histiocytoma of skin
  • Malignant granular cell tumor
  • Malignant melanoma of soft tissues
  • Malignant neoplasm of bone, connective tissue, skin and breast
  • Malignant neoplasm of connective tissue
  • Malignant neoplasm of soft tissue
  • Malignant neoplasm of subcutaneous fibrous tissue
  • Malignant tumor of dermis
  • Malignant tumor of fibrous tissue
  • Malignant tumor of muscle
  • Malignant tumor of nerve sheath origin
  • Metastasis from malignant tumor of soft tissues
  • Myxofibrosarcoma of skin
  • Myxoid leiomyosarcoma of skin
  • Myxoid liposarcoma
  • Pleomorphic liposarcoma
  • Pleomorphic malignant fibrous histiocytoma of skin
  • Pleomorphic rhabdomyosarcoma
  • Primary leiomyosarcoma
  • Primary malignant neoplasm of blood vessel
  • Primary malignant neoplasm of muscle
  • Primary malignant neoplasm of soft tissues
  • Rhabdomyosarcoma
  • Rhabdomyosarcoma of connective or soft tissue
  • Round cell liposarcoma
  • Sarcoma
  • Sarcoma of bone and connective tissue
  • Sarcoma of connective tissue
  • Sarcoma of soft tissue
  • Sclerosing liposarcoma
  • Spindle cell liposarcoma
  • Spindle cell rhabdomyosarcoma
  • Superficial malignant fibrous histiocytoma of skin
  • Surgical margin involved by sarcoma
  • Surgical margin involvement by sarcoma cannot be assessed
  • Surgical margin uninvolved by sarcoma
  • Synovial sarcoma
  • Synovial-like neoplasm
  • Vaccine-induced fibrosarcoma

Table of Neoplasms

The code C49.9 is included in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

The Tabular must be reviewed for the complete diagnosis code.

Neoplasm, neoplastic Malignant
CaInSitu Benign Uncertain
»connective tissue NEC
»connective tissue NEC
»connective tissue NEC
  »limb NEC
»lymph, lymphatic channel NEC
»lymph, lymphatic channel NEC
  »vessel [See Also: Neoplasm, connective tissue]

Information for Patients


Also called: Carcinoma, Malignancy, Neoplasms, Tumor

Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for where they start. For example, lung cancer starts in the lung, and breast cancer starts in the breast. The spread of cancer from one part of the body to another is called metastasis. Symptoms and treatment depend on the cancer type and how advanced it is. Most treatment plans may include surgery, radiation and/or chemotherapy. Some may involve hormone therapy, immunotherapy or other types of biologic therapy, or stem cell transplantation.

NIH: National Cancer Institute

  • Cancer (Medical Encyclopedia)
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  • Cancer treatment -- early menopause (Medical Encyclopedia)
  • Cancer treatment: preventing infection (Medical Encyclopedia)
  • Cancer treatments (Medical Encyclopedia)
  • How to research cancer (Medical Encyclopedia)
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  • Hyperthermia for treating cancer (Medical Encyclopedia)
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  • Photodynamic therapy for cancer (Medical Encyclopedia)
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  • Understanding your cancer prognosis (Medical Encyclopedia)
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Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Over 200 disorders that impact connective tissue. There are different types:

  • Genetic disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta
  • Autoimmune disorders, such as lupus and scleroderma
  • Cancers, like some types of soft tissue sarcoma

Each disorder has its own symptoms and needs different treatment.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

  • Dupuytrens contracture (Medical Encyclopedia)

[Read More]
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