Not Valid for Submission
Q85.0 is a "header" nonspecific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of neurofibromatosis (nonmalignant). The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.
Specific Coding for Neurofibromatosis (nonmalignant)
Header codes like Q85.0 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for neurofibromatosis (nonmalignant):
- NEUROFIBROMATOSIS 1-. an autosomal dominant inherited disorder with a high frequency of spontaneous mutations that features developmental changes in the nervous system muscles bones and skin most notably in tissue derived from the embryonic neural crest. multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. peripheral and central nervous system neoplasms occur frequently especially optic nerve glioma and neurofibrosarcoma. nf1 is caused by mutations which inactivate the nf1 gene genes neurofibromatosis 1 on chromosome 17q. the incidence of learning disabilities is also elevated in this condition. from adams et al. principles of neurology 6th ed pp1014 18 there is overlap of clinical features with noonan syndrome in a syndrome called neurofibromatosis noonan syndrome. both the ptpn11 and nf1 gene products are involved in the signal transduction pathway of ras ras proteins.
- GENES NEUROFIBROMATOSIS 1-. tumor suppressor genes located on the long arm of human chromosome 17 in the region 17q11.2. mutation of these genes is thought to cause neurofibromatosis 1 watson syndrome and leopard syndrome.
- GENES NEUROFIBROMATOSIS 2-. tumor suppressor genes located on the long arm of human chromosome 22. mutation or loss of these genes causes neurofibromatosis 2.
- NEUROFIBROMATOSIS 2-. an autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas neurilemmoma of other cranial and peripheral nerves and other benign intracranial tumors including meningiomas ependymomas spinal neurofibromas and gliomas. the disease has been linked to mutations of the nf2 gene genes neurofibromatosis 2 on chromosome 22 22q12 and usually presents clinically in the first or second decade of life.
- NEUROFIBROMATOSES-. a group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. neurofibromatosis 1 generalized neurofibromatosis accounts for approximately 95% of cases although multiple additional subtypes e.g. neurofibromatosis 2 neurofibromatosis 3 etc. have been described. from neurochirurgie 1998 nov;444:267 72
- NEUROFIBROMIN 1-. a protein found most abundantly in the nervous system. defects or deficiencies in this protein are associated with neurofibromatosis 1 watson syndrome and leopard syndrome. mutations in the gene gene neurofibromatosis 1 affect two known functions: regulation of ras gtpase and tumor suppression.
- NEUROFIBROMIN 2-. a membrane protein homologous to the erm ezrin radixin moesin family of cytoskeleton associated proteins which regulate physical properties of membranes. alterations in neurofibromin 2 are the cause of neurofibromatosis 2.
Information for Patients
Also called: Recklinghausen's disease, von Recklinghausen's disease
Neurofibromatosis is a genetic disorder of the nervous system. It mainly affects how nerve cells form and grow. It causes tumors to grow on nerves. You can get neurofibromatosis from your parents, or it can happen because of a mutation (change) in your genes. Once you have it, you can pass it along to your children. Usually the tumors are benign, but sometimes they can become cancerous.
There are three types of neurofibromatosis:
- Type 1 (NF1) causes skin changes and deformed bones. It usually starts in childhood. Sometimes the symptoms are present at birth.
- Type 2 (NF2) causes hearing loss, ringing in the ears, and poor balance. Symptoms often start in the teen years.
- Schwannomatosis causes intense pain. It is the rarest type.
Doctors diagnose the different types based on the symptoms. Genetic testing is also used to diagnose NF1 and NF2. There is no cure. Treatment can help control symptoms. Depending on the type of disease and how serious it is, treatment may include surgery to remove tumors, radiation therapy, and medicines.
NIH: National Institute of Neurological Disorders and Stroke
- Neurofibromatosis 2 (Medical Encyclopedia)
- Neurofibromatosis-1 (Medical Encyclopedia)
- Optic glioma (Medical Encyclopedia)
Neurofibromatosis type 1 Neurofibromatosis type 1 is a condition characterized by changes in skin coloring (pigmentation) and the growth of tumors along nerves in the skin, brain, and other parts of the body. The signs and symptoms of this condition vary widely among affected people.Beginning in early childhood, almost all people with neurofibromatosis type 1 have multiple café-au-lait spots, which are flat patches on the skin that are darker than the surrounding area. These spots increase in size and number as the individual grows older. Freckles in the underarms and groin typically develop later in childhood.Most adults with neurofibromatosis type 1 develop neurofibromas, which are noncancerous (benign) tumors that are usually located on or just under the skin. These tumors may also occur in nerves near the spinal cord or along nerves elsewhere in the body. Some people with neurofibromatosis type 1 develop cancerous tumors that grow along nerves. These tumors, which usually develop in adolescence or adulthood, are called malignant peripheral nerve sheath tumors. People with neurofibromatosis type 1 also have an increased risk of developing other cancers, including brain tumors and cancer of blood-forming tissue (leukemia).During childhood, benign growths called Lisch nodules often appear in the colored part of the eye (the iris). Lisch nodules do not interfere with vision. Some affected individuals also develop tumors that grow along the nerve leading from the eye to the brain (the optic nerve). These tumors, which are called optic gliomas, may lead to reduced vision or total vision loss. In some cases, optic gliomas have no effect on vision.Additional signs and symptoms of neurofibromatosis type 1 vary, but they can include high blood pressure (hypertension), short stature, an unusually large head (macrocephaly), and skeletal abnormalities such as an abnormal curvature of the spine (scoliosis). Although most people with neurofibromatosis type 1 have normal intelligence, learning disabilities and attention-deficit/hyperactivity disorder (ADHD) occur frequently in affected individuals.
Neurofibromatosis type 2 Neurofibromatosis type 2 is a disorder characterized by the growth of noncancerous tumors in the nervous system. The most common tumors associated with neurofibromatosis type 2 are called vestibular schwannomas or acoustic neuromas. These growths develop along the nerve that carries information from the inner ear to the brain (the auditory nerve). Tumors that occur on other nerves are also commonly found with this condition.The signs and symptoms of neurofibromatosis type 2 usually appear during adolescence or in a person's early twenties, although they can begin at any age. The most frequent early symptoms of vestibular schwannomas are hearing loss, ringing in the ears (tinnitus), and problems with balance. In most cases, these tumors occur in both ears by age 30. If tumors develop elsewhere in the nervous system, signs and symptoms vary according to their location. Complications of tumor growth can include changes in vision, numbness or weakness in the arms or legs, and fluid buildup in the brain. Some people with neurofibromatosis type 2 also develop clouding of the lens (cataracts) in one or both eyes, often beginning in childhood.