2026 ICD-10-CM Diagnosis Code E78.5Hyperlipidemia, unspecified

ICD-10-CM Codes›E00–E89›E70-E88›E78

ICD-10-CM E78.5
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E78.5 is a billable ICD-10-CM diagnosis code for hyperlipidemia, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Disorders of lipid metabolism.

Code Identity

ICD-10-CM Code
E78.5
Billable Status
Yes — Valid for Submission
Code Describes
Hyperlipidemia, unspecified
Short Description
Hyperlipidemia, unspecified
Same as the full description in the CMS dataset.
Parent Code
E78
Disorders of lipoprotein metabolism and other lipidemias

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE78Disorders of lipoprotein metabolism and other lipidemias
This CodeE78.5Hyperlipidemia, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Complex dyslipidemia
  • Dyslipidemia
  • Dyslipidemia due to type 1 diabetes mellitus
  • Dyslipidemia due to type 2 diabetes mellitus
  • Familial hyperlipoproteinemia
  • Gastric xanthoma
  • Hyperlipidemia
  • Hyperlipidemia caused by steroid
  • Hyperlipidemia due to type 1 diabetes mellitus
  • Hyperlipidemia due to type 2 diabetes mellitus
  • Hyperlipidemia with lipid deposition in skin
  • Hyperlipoproteinemia
  • Lipid above reference range
  • Posttransplant hyperlipidemia
  • Secondary hyperlipidemia
  • Xanthoma due to abnormality of lipid metabolism
  • Xanthoma due to secondary hyperlipidemia

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dyslipidemia
    • Hyperlipemia, hyperlipidemia
    • Hyperlipoproteinemia
    • Lipoproteinemia
    • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
      • hyperlipidemic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END010
Disorders of lipid metabolism
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Family History of Hyperlipidemia|Hyperlipidemia

    a history of a first-degree relative that has hyperlipidemia.

  • Grade 1 Hyperlipidemia, CTCAE|Grade 1 Hyperlipidemia

    requiring diet changes

  • Grade 2 Hyperlipidemia, CTCAE|Grade 2 Hyperlipidemia

    requiring pharmaceutical intervention

  • Grade 3 Hyperlipidemia, CTCAE|Grade 3 Hyperlipidemia

    hospitalization; pancreatitis

  • Grade 4 Hyperlipidemia, CTCAE|Grade 4 Hyperlipidemia

    life-threatening consequences

  • Hyperlipidemia

    elevated levels of lipids in the blood.

  • Hyperlipidemia, CTCAE|Hyperlipidemia

    a disorder characterized by laboratory test results that indicate an elevation in the concentration of lipids in blood.

  • Hyperlipoproteinemia, Type II|Type II Hyperlipidemia

    an inheritable form of hyperlipidemia, in which there are excess lipids in the blood.

  • Hyperlipoproteinemia, Type IIa|FH|Familial Hypercholesterolemia|Hyperlipidemia Type IIa|Type IIa Hyperlipidemia

    an autosomal dominant inherited disorder characterized by very high levels of low-density lipoprotein cholesterol (ldl-c) and total cholesterol in the blood. it is usually caused by mutations in the ldlr gene which is located on the short arm of chromosome 19.

  • Hyperlipoproteinemia, Type IIb|Familial Combined Hyperlipidemia|Hyperlipidemia Type IIb|Type IIb Hyperlipidemia|Type IIb Hyperlipoproteinemia

    a disorder of lipoprotein metabolism characterized by high levels of cholesterol and triglycerides in the blood. it is caused by elevation of low density and very low density lipoproteins.

  • Remnant Hyperlipidemia

    a laboratory test result indicating a type of inherited dysbetalipoproteinemia in which the triglyceride and total cholesterol concentrations are increased and the high-density lipoprotein concentration is decreased.

  • Grade 3 Hyperlipidemia, CTCAE|Grade 3 Hyperlipidemia

    hospitalization

  • Mixed Hyperlipidemia

    a dyslipidemia characterized by elevated serum levels of total and low-density cholesterol, and triglycerides.

  • CDISC Dyslipidemia Therapeutic Area User Guide Version 1.0|Dyslipidemia Therapeutic Area User Guide v1.0

    the 1.0 version of the cdisc dyslipidemia therapeutic area user guide.

  • Dyslipidemia

    a lipoprotein metabolism disorder characterized by decreased levels of high-density lipoproteins, or elevated levels of plasma cholesterol, low-density lipoproteins and/or triglycerides.

  • Hyperlipoproteinemia

    an elevated concentration of lipoproteins.

  • Hyperlipoproteinemia, Type I|Familial Essential Hyperlipemia|Familial Hyperchylomicronemia|Hyperlipoproteinemia Type 1A|Lipoprotein Lipase Deficiency

    a genetic disorder of lipoprotein metabolism caused by mutations in the lpl and apolipoprotein (apo) c-ii genes. it is characterized by increased levels of chylomicrons and triglycerides in the blood.

  • Hyperlipoproteinemia, Type I|Familial Essential Hyperlipemia|Familial Hyperchylomicronemia|Hyperlipoproteinemia Type 1A|Lipoprotein Lipase Deficiency

    a genetic condition caused by mutation(s) in the lpl gene, encoding lipoprotein lipase, resulting in reduced activity of the enzyme lipoprotein lipase.

Patient EducationClinical

Cholesterol

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your body needs some cholesterol to make hormones, vitamin D, and substances that help you digest foods. Your body makes all the cholesterol it needs. Cholesterol is also found in foods from animal sources, such as egg yolks, meat, and cheese.

The full article covers:

  • What is cholesterol?
  • What are HDL, LDL, and VLDL?
  • What causes high cholesterol?
  • What can raise my risk of high cholesterol?
  • What other health problems can high cholesterol cause?
  • How is high cholesterol diagnosed?
  • How can I lower my cholesterol?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E78.5 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
272.4 Hyperlipidemia NEC/NOS
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E78.5Overview

Is E78.5 (Disorders of lipoprotein metabolism and other lipidemias) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hyperlipidemia, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of E78.5?

Under the General Equivalence Mappings, hyperlipidemia, unspecified converts to ICD-9-CM 272.4 (hyperlipidemia NEC/NOS). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.