2026 ICD-10-CM Diagnosis Code E78.49Other hyperlipidemia

ICD-10-CM Codes›E00–E89›E70-E88›E78

ICD-10-CM E78.49
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E78.49 is a billable ICD-10-CM diagnosis code for other hyperlipidemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as chemically induced hyperlipidemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Disorders of lipid metabolism.

Code Identity

ICD-10-CM Code
E78.49
Billable Status
Yes — Valid for Submission
Code Describes
Other hyperlipidemia
Short Description
Other hyperlipidemia
Same as the full description in the CMS dataset.
Parent Code
E78.4
Other hyperlipidemia

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE78Disorders of lipoprotein metabolism and other lipidemias
This CodeE78.49Other hyperlipidemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Chemically induced hyperlipidemia
  • Exogenous hyperlipidemia
  • Familial combined hyperlipidemia
  • Familial multiple lipoprotein-type hyperlipidemia
  • Mixed hyperlipidemia
  • Primary combined hyperlipidemia
  • Secondary hypercholesterolemia
  • Secondary hyperlipidemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Familial combined hyperlipidemia

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hyperlipemia, hyperlipidemia
      • combined
        • familial
    • Hyperlipemia, hyperlipidemia
      • specified NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END010
Disorders of lipid metabolism
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Family History of Hyperlipidemia|Hyperlipidemia

    a history of a first-degree relative that has hyperlipidemia.

  • Grade 1 Hyperlipidemia, CTCAE|Grade 1 Hyperlipidemia

    requiring diet changes

  • Grade 2 Hyperlipidemia, CTCAE|Grade 2 Hyperlipidemia

    requiring pharmaceutical intervention

  • Grade 3 Hyperlipidemia, CTCAE|Grade 3 Hyperlipidemia

    hospitalization; pancreatitis

  • Grade 4 Hyperlipidemia, CTCAE|Grade 4 Hyperlipidemia

    life-threatening consequences

  • Hyperlipidemia

    elevated levels of lipids in the blood.

  • Hyperlipidemia, CTCAE|Hyperlipidemia

    a disorder characterized by laboratory test results that indicate an elevation in the concentration of lipids in blood.

  • Hyperlipoproteinemia, Type II|Type II Hyperlipidemia

    an inheritable form of hyperlipidemia, in which there are excess lipids in the blood.

  • Hyperlipoproteinemia, Type IIa|FH|Familial Hypercholesterolemia|Hyperlipidemia Type IIa|Type IIa Hyperlipidemia

    an autosomal dominant inherited disorder characterized by very high levels of low-density lipoprotein cholesterol (ldl-c) and total cholesterol in the blood. it is usually caused by mutations in the ldlr gene which is located on the short arm of chromosome 19.

  • Hyperlipoproteinemia, Type IIb|Familial Combined Hyperlipidemia|Hyperlipidemia Type IIb|Type IIb Hyperlipidemia|Type IIb Hyperlipoproteinemia

    a disorder of lipoprotein metabolism characterized by high levels of cholesterol and triglycerides in the blood. it is caused by elevation of low density and very low density lipoproteins.

  • Remnant Hyperlipidemia

    a laboratory test result indicating a type of inherited dysbetalipoproteinemia in which the triglyceride and total cholesterol concentrations are increased and the high-density lipoprotein concentration is decreased.

  • Grade 3 Hyperlipidemia, CTCAE|Grade 3 Hyperlipidemia

    hospitalization

  • Mixed Hyperlipidemia

    a dyslipidemia characterized by elevated serum levels of total and low-density cholesterol, and triglycerides.

Patient EducationClinical

Cholesterol

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your body needs some cholesterol to make hormones, vitamin D, and substances that help you digest foods. Your body makes all the cholesterol it needs. Cholesterol is also found in foods from animal sources, such as egg yolks, meat, and cheese.

The full article covers:

  • What is cholesterol?
  • What are HDL, LDL, and VLDL?
  • What causes high cholesterol?
  • What can raise my risk of high cholesterol?
  • What other health problems can high cholesterol cause?
  • How is high cholesterol diagnosed?
  • How can I lower my cholesterol?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement E78.49 replaces the following previously assigned code(s):

  • E78.4 - Other hyperlipidemia
FY 2019AddedAdded to the ICD-10-CM code setEffective October 1, 2018.
FY 2020–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E78.49Overview

Is E78.49 (Other hyperlipidemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other hyperlipidemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.