2027 ICD-10-CM Diagnosis Code E75.5Other lipid storage disorders
ICD-10-CM Codes›E00–E89›E70-E88›E75
- Billable — Valid for Submission
- Chronic Condition
E75.5 is a billable ICD-10-CM diagnosis code for other lipid storage disorders. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
E75.5 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E75.5 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Ataxia due to cerebrotendinous xanthomatosis
- Chemically-induced lipidosis
- Cholestanol storage disease
- Cholesterol ester storage disease
- Disorder of cholesterol catabolism
- Disorder of cholesterol metabolism
- Disorder of lipid storage and metabolism
- Disorder of sialic acid metabolism
- Familial disease with storage of sterols
- Ichthyosiform erythroderma
- Infiltrative cardiomyopathy
- Lipid storage myopathy
- Lysosomal acid lipase deficiency
- Neutral lipid storage disease with myopathy
- Papular xanthoma
- Primary triglyceride deposit cardiomyovasculopathy
- Pulmonary lipid storage disease
- Salla disease
- Sialic storage disease
- Sitosterolemia
- Sitosterolemia with xanthomatosis
- Synthetic defect of bile acids
- Triglyceride deposit cardiomyovasculopathy
- Triglyceride storage disease with ichthyosis
- Wolman's disease
- Xanthoma due to abnormality of lipid metabolism
- Xanthoma due to lipid storage disease
- Xanthoma of lung
- Xanthoma tendinosum
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E75.5: its own notes plus those printed at E75, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein]
- Wolman's disease
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E75.5, its category, or a range that includes it.
Excludes1 2
These codes carry an Excludes1 note naming E75.5: they are not reported together with it, unless the two conditions are unrelated.
Code First 2
These codes say to code first a condition named in the note, and E75.5 is one of the conditions named.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disease, diseased See Also: Syndrome;
specified NEC E75.5
triglyceride-storage E75.5
Disorder (of) See Also: Disease;
specified NEC E75.5
Wolman's disease E75.5
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Wolman Disease
the severe infantile form of inherited lysosomal lipid storage diseases due to deficiency of acid lipase (sterol esterase). it is characterized by the accumulation of neutral lipids, particularly cholesterol esters in leukocytes, fibroblasts, and hepatocytes. it is also known as wolman's xanthomatosis and is an allelic variant of cholesterol ester storage disease.
Patient EducationClinical
Metabolic Disorders
Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E75.5 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E75.5Overview
What is the ICD-10 code for other lipid storage disorders?
The ICD-10-CM code for other lipid storage disorders is E75.5 (sometimes written as E755). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E75.5 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other lipid storage disorders on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E75.5 group to?
When other lipid storage disorders is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Can E75.5 be reported with G60.1?
Not as a rule. The Excludes1 note at E75, which applies to E75.5, lists "Refsum's disease (G60.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of E75.5?
Under the General Equivalence Mappings, other lipid storage disorders converts to ICD-9-CM 272.8 (lipoid metabol dis NEC). The mapping is approximate, so confirm the match fits the documentation.
Does E75.5 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage: E75.5 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
