2026 ICD-10-CM Diagnosis Code E75.22Gaucher disease

ICD-10-CM Codes›E00–E89›E70-E88›E75

ICD-10-CM E75.22
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E75.22 is a billable ICD-10-CM diagnosis code for gaucher disease. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E75.22
Billable Status
Yes — Valid for Submission
Code Describes
Gaucher disease
Short Description
Gaucher disease
Same as the full description in the CMS dataset.
Parent Code
E75.2
Other sphingolipidosis

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE75Disorders of sphingolipid metabolism and other lipid storage disorders
This CodeE75.22Gaucher disease

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acute neuronopathic Gaucher's disease
  • Atypical Gaucher disease due to saposin C deficiency
  • Cerebral degeneration in Gaucher's disease
  • Chronic non-neuropathic Gaucher's disease
  • Gaucher disease with ophthalmoplegia and cardiovascular calcification
  • Gaucher's disease
  • Kerasin thesaurismosis
  • Perinatal lethal Gaucher disease
  • Subacute neuronopathic Gaucher's disease

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Cerebroside lipidosis
    • Degeneration, degenerative
      • brain (cortical) (progressive)
        • in
          • Gaucher's disease
    • Gaucher's disease or splenomegaly(adult) (infantile)
    • Lipidosis
      • cerebroside
    • Splenomegaly, splenomegalia(Bengal) (cryptogenic) (idiopathic) (tropical)
      • Gaucher's

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Gaucher Disease

    an autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (glucosylceramidase) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the mononuclear phagocyte system. the characteristic gaucher cells, glycosphingolipid-filled histiocytes, displace normal cells in bone marrow and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. there are several subtypes based on the presence and severity of neurological involvement.

Patient EducationClinical

Gaucher Disease

Gaucher disease is a rare, inherited disorder. It is a type of lipid metabolism disorder. If you have it, you do not have enough of an enzyme called glucocerebrosidase. This causes too much of a fatty substance to build up in your spleen, liver, lungs, bones and, sometimes, your brain. This prevents these organs from working properly.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E75.22 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
272.7 Lipidoses
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E75.22Overview

Is E75.22 (Other sphingolipidosis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report gaucher disease on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of E75.22?

Under the General Equivalence Mappings, gaucher disease converts to ICD-9-CM 272.7 (lipidoses). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.