2027 ICD-10-CM Diagnosis Code E74.89Other specified disorders of carbohydrate metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E74

ICD-10-CM E74.89
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E74.89 is a billable ICD-10-CM diagnosis code for other specified disorders of carbohydrate metabolism. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 55 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

E74.89 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.

Code Identity

ICD-10-CM Code
E74.89
Billable Status
Yes — Valid for Submission
Code Describes
Other specified disorders of carbohydrate metabolism
Short Description
Other specified disorders of carbohydrate metabolism
Same as the full description in the CMS dataset.
Parent Code
E74.8
Other specified disorders of carbohydrate metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE74Other disorders of carbohydrate metabolism
This CodeE74.89Other specified disorders of carbohydrate metabolism

Medicare Risk Adjustment (HCC)Billing

E74.89 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 23
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 23 · ESRD (V21): HCC 23 · ESRD (V24): HCC 23
ESRD V21 weights: 0.013 dialysis, 0.234–0.359 functioning graft · ESRD V24 weights: 0.036 dialysis, 0.217–0.390 functioning graft
Part D (RxHCC)
RxHCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • ALG1 congenital disorder of glycosylation
  • ALG12-congenital disorder of glycosylation
  • ALG3 congenital disorder of glycosylation
  • ALG8 congenital disorder of glycosylation
  • ALG9 congenital disorder of glycosylation
  • CCDC115 congenital disorder of glycosylation
  • COG1 congenital disorder of glycosylation
  • COG4 congenital disorder of glycosylation
  • COG5 congenital disorder of glycosylation
  • COG7 congenital disorder of glycosylation
  • COG8 congenital disorder of glycosylation
  • Congenital disorder of glycosylation type 1c
  • Congenital disorder of glycosylation type 1cc
  • Congenital disorder of glycosylation type 1e
  • Congenital disorder of glycosylation type 1f
  • Congenital disorder of glycosylation type 1i
  • Congenital disorder of glycosylation type 1j
  • Congenital disorder of glycosylation type 1n
  • Congenital disorder of glycosylation type 1p
  • Congenital disorder of glycosylation type 1q
  • Congenital disorder of glycosylation type 1r
  • Congenital disorder of glycosylation type 1s
  • Congenital disorder of glycosylation type 1w
  • Congenital disorder of glycosylation type 1x
  • Congenital disorder of glycosylation type 1y
  • Congenital myasthenic syndrome
  • Congenital myasthenic syndrome with glycosylation defect due to ALG14 UDP-N-acetylglucosaminyltransferase subunit gene mutation
  • Deficiency of aldehyde reductase
  • Deficiency of aldonolactonase
  • Deficiency of aldose 1-epimerase
  • Deficiency of ALG14 UDP-N-acetylglucosamine transferase
  • Deficiency of alpha-amylase
  • Deficiency of alpha-mannosidase
  • Deficiency of amylase
  • Deficiency of amylo-1,6-glucosidase
  • Deficiency of amylopectin 6-glucanohydrolase
  • Deficiency of benzaldehyde dehydrogenase
  • Deficiency of beta-amylase
  • Deficiency of beta-fructofuranosidase
  • Deficiency of beta-glucosidase
  • Deficiency of beta-glucuronidase
  • Deficiency of bisphosphoglycerate mutase
  • Deficiency of bisphosphoglycerate phosphatase
  • Deficiency of endo-1,3-beta-glucanase
  • Deficiency of glucan 1,3-alpha-glucosidase
  • Deficiency of glucokinase
  • Deficiency of gluconate 2-dehydrogenase
  • Deficiency of gluconokinase
  • Deficiency of gluconolactonase
  • Deficiency of glucosamine-6-phosphate isomerase
  • Deficiency of glucose dehydrogenase
  • Deficiency of glucose oxidase
  • Deficiency of glucose-1-phosphatase
  • Deficiency of glucose-6-phosphate isomerase
  • Deficiency of glucosyltransferase 1
  • Deficiency of glyceraldehyde-3-phosphate dehydrogenase
  • Deficiency of glycerol kinase
  • Deficiency of glycosidase
  • Deficiency of glycosulfatase
  • Deficiency of glycosyltransferase
  • Deficiency of maltose phosphorylase
  • Deficiency of mannokinase
  • Deficiency of phosphoglucokinase
  • Deficiency of phosphoglycerate kinase
  • Deficiency of phosphomannomutase 2
  • Deficiency of phosphorylase b kinase
  • Deficiency of protein kinase
  • Deficiency of rhamnulokinase
  • Deficiency of xylulokinase
  • D-Glyceric aciduria
  • Disacchariduria
  • Disorder of glucose metabolism
  • Disorder of glucose regulation
  • Disorder of glycerate metabolism
  • Disorder of glycerol metabolism
  • Essential pentosuria
  • Genetically determined myasthenia
  • Glycerol intolerance syndrome
  • Glycerol kinase deficiency - isolated
  • Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
  • Hyperimmunoglobulin E syndrome
  • Mannosyl-oligosaccharide glycosidase congenital disorder of glycosylation
  • Muscle phosphoglycerate mutase deficiency
  • Myasthenic syndrome due to another disorder
  • Nonglucosuric melituria
  • Pentose disorder
  • PGM1-related congenital disorder of glycosylation
  • PGM3-related congenital disorder of glycosylation
  • SLC35A1 congenital disorder of glycosylation
  • SLC39A8 congenital disorder of glycosylation
  • Solute carrier family 35 member A2 congenital disorder of glycosylation
  • Syndrome of carbohydrate intolerance
  • Trehalase deficiency
  • Xylosuria
  • XYLT1-CDG - xylosyltransferase 1 congenital disorder of glycosylation

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E74.89: its own notes plus those printed at E74, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Essential pentosuria

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E74 Other disorders of carbohydrate metabolism applies to 24 codes
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E74.89, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming E74.89: they are not reported together with it, unless the two conditions are unrelated.

  • R79 Other abnormal findings of blood chemistry
    specific findings indicating disorder of carbohydrate metabolism (E73-E74) names E73-E74, which includes this code
  • Block R80-R82 Abnormal findings on examination of urine, without diagnosis
    specific findings indicating disorder of carbohydrate metabolism (E73-E74) names E73-E74, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement E74.89 replaces the following previously assigned code(s):

  • E74.8 - Other specified disorders of carbohydrate metabolism
FY 2021AddedAdded to the ICD-10-CM code setEffective October 1, 2020.
FY 2022–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E74.89Overview

What is the ICD-10 code for other specified disorders of carbohydrate metabolism?

The ICD-10-CM code for other specified disorders of carbohydrate metabolism is E74.89 (sometimes written as E7489). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E74.89 (Other specified disorders of carbohydrate metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other specified disorders of carbohydrate metabolism on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E74.89 group to?

When other specified disorders of carbohydrate metabolism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.

Is E74.89 a CC or MCC?

CMS lists E74.89 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 55 closely related codes in its exclusion list.

Can E74.89 be reported with E16.2?

Not as a rule. The Excludes1 note at E74, which applies to E74.89, lists "hypoglycemia NOS (E16.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E74.89 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. E74.89 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).