2026 ICD-10-CM Diagnosis Code D89.3Immune reconstitution syndrome
ICD-10-CM Codes›D50–D89›D80-D89›D89
- Billable — Valid for Submission
- Chronic Condition
D89.3 is a billable ICD-10-CM diagnosis code for immune reconstitution syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.
D89.3 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 47 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 47, ESRD (V21) category 47, ESRD (V24) category 47, and RxHCC Part D (V08) category 99 for payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D89.3 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Disorder of immune reconstitution
- Engraftment reaction
- Engraftment syndrome
- Evidence of immune reconstitution
- Immune reconstitution finding
- Immune reconstitution inflammatory syndrome
- Immune reconstitution reaction
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Immune reconstitution inflammatory syndrome [IRIS]
Use Additional Code
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Syndrome See Also: Disease;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Immune Reconstitution Inflammatory Syndrome
exuberant inflammatory response towards a previously acquired or undiagnosed opportunistic infection. it is frequently seen in aids patients following antiretroviral treatment.Engraftment Syndrome
a toxicity of hematopoietic stem cell transplantation that manifests as fever, rash and pulmonary deterioration which becomes evident at marrow engraftment. it occurs unexpectedly and is occasionally fatal. it can occur after an autogeneic or an allogeneic hematopoietic cell transplantation.
Patient EducationClinical
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
The full article covers:
- What is the immune system?
- What are the parts of the immune system?
- How does the immune system work?
- What are the types of immunity?
- What can go wrong with the immune system?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D89.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D89.3Overview
What is the ICD-10 code for immune reconstitution syndrome?
The ICD-10-CM code for immune reconstitution syndrome is D89.3 (sometimes written as D893). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is D89.3 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report immune reconstitution syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D89.3 group to?
When immune reconstitution syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D89.3?
Under the General Equivalence Mappings, immune reconstitution syndrome converts to ICD-9-CM 279.8 (immune mechanism dis NEC). The mapping is approximate, so confirm the match fits the documentation.
Does D89.3 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D89.3 mapped to HCC 47 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 47 (Disorders of Immunity), ESRD (V21) category 47 (Disorders of Immunity), ESRD (V24) category 47 (Disorders of Immunity), and RxHCC Part D (V08) category 99 (Immune Disorders).
