ICD-9 Code 279.8

Other specified disorders involving the immune mechanism

Not Valid for Submission

279.8 is a legacy non-billable code used to specify a medical diagnosis of other specified disorders involving the immune mechanism. This code was replaced on September 30, 2015 by its ICD-10 equivalent.

ICD-9: 279.8
Short Description:Immune mechanism dis NEC
Long Description:Other specified disorders involving the immune mechanism

Convert 279.8 to ICD-10

The following crosswalk between ICD-9 to ICD-10 is based based on the General Equivalence Mappings (GEMS) information:

  • D84.1 - Defects in the complement system
  • D89.89 - Oth disrd involving the immune mechanism, NEC
  • M35.9 - Systemic involvement of connective tissue, unspecified

Code Classification

  • Endocrine, nutritional and metabolic diseases, and immunity disorders (240–279)
    • Other metabolic disorders and immunity disorders (270-279)
      • 279 Disorders involving the immune mechanism

Information for Medical Professionals


  • Abnormal host defense
  • Adult linear immunoglobulin A disease
  • Age-related immunodeficiency
  • Alternative pathway deficiency
  • Anaphylotoxin inactivator deficiency
  • Angioedema due to disorder of C1 esterase inhibitor
  • Autoimmune AND/OR graft reaction
  • Autologous state
  • Classical complement pathway abnormality
  • Clonal anergy
  • Complement 1q beta chain deficiency
  • Complement 1q deficiency
  • Complement 1q dysfunction
  • Complement 1r deficiency
  • Complement 1s deficiency
  • Complement 2 deficiency
  • Complement 3 deficiency
  • Complement 4 binding protein deficiency
  • Complement 4 deficiency
  • Complement 4A deficiency
  • Complement 4B deficiency
  • Complement 5 deficiency
  • Complement 5 dysfunction
  • Complement 5a inhibitor deficiency
  • Complement 6 deficiency
  • Complement 7 deficiency
  • Complement 8 alpha-gamma deficiency
  • Complement 8 beta chain deficiency
  • Complement 8 beta chain dysfunction
  • Complement 9 deficiency
  • Complement abnormality
  • Complement component deficiency
  • Complement deficiency disease
  • Complement receptor 1 deficiency
  • Complement receptor 3 deficiency
  • Complement receptor deficiency
  • Complement regulatory factor defect
  • Cutis laxa with complement deficiency
  • Decay accelerating factor deficiency
  • Defective phagocytic cell chemotaxis
  • Disorder of complement
  • Disorder of kidney due to kappa light chain disease
  • Disorder of kidney due to lambda light chain disease
  • Factor B deficiency
  • Factor D deficiency
  • Factor H deficiency
  • Familial C3B inhibitor deficiency syndrome
  • Familial immunoglobulin hypercatabolism
  • Hereditary C1 esterase inhibitor deficiency - deficient factor
  • Hereditary C1 esterase inhibitor deficiency - dysfunctional factor
  • Homologous restriction factor deficiency
  • Hyperimmune state
  • Hyperimmunoglobulin D with periodic fever
  • Immune reconstitution syndrome
  • Immunodeficiency associated with chromosomal abnormality
  • Immunodeficiency with major anomalies
  • Immunoglobulin hypercatabolism
  • Kappa light chain disease
  • Neutrophil secondary granule deficiency
  • Panniculitis with complement deficiency
  • Phagocytic cell defect
  • Postinfectious autoimmune reaction
  • Predominant humoral immune deficiency
  • Primary immune deficiency disorder
  • Primary immunoglobulin catabolism abnormality
  • Properdin deficiency disease
  • Reticuloendothelial blockade
  • Secondary immune deficiency disorder
  • Terminal component deficiency
  • T-lymphocyte deficiency
  • X-linked hyperimmunoglobulin M syndrome

Index to Diseases and Injuries

References found for the code 279.8 in the Index of Diseases and Injuries:

Information for Patients

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

NIH: National Institute of Allergy and Infectious Diseases

  • Agammaglobulinemia
  • Aging changes in immunity
  • Chronic granulomatous disease
  • Graft-versus-host disease
  • Histiocytosis
  • Hyperimmunoglobulin E syndrome
  • Immune response
  • Immunodeficiency disorders
  • Nitroblue tetrazolium test
  • Quantitative nephelometry
  • Selective deficiency of IgA
  • Serum sickness

[Read More]

ICD-9 Footnotes

General Equivalence Map Definitions
The ICD-9 and ICD-10 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.

Index of Diseases and Injuries Definitions

  • And - The word "and" should be interpreted to mean either "and" or "or" when it appears in a title.
  • Code also note - A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
  • Code first - Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • Type 1 Excludes Notes - A type 1 Excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Type 2 Excludes Notes - A type 2 Excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • Includes Notes - This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
  • Inclusion terms - List of terms is included under some codes. These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • NEC "Not elsewhere classifiable" - This abbreviation in the Alphabetic Index represents "other specified". When a specific code is not available for a condition, the Alphabetic Index directs the coder to the "other specified” code in the Tabular List.
  • NOS "Not otherwise specified" - This abbreviation is the equivalent of unspecified.
  • See - The "see" instruction following a main term in the Alphabetic Index indicates that another term should be referenced. It is necessary to go to the main term referenced with the "see" note to locate the correct code.
  • See Also - A "see also" instruction following a main term in the Alphabetic Index instructs that there is another main term that may also be referenced that may provide additional Alphabetic Index entries that may be useful. It is not necessary to follow the "see also" note when the original main term provides the necessary code.
  • 7th Characters - Certain ICD-10-CM categories have applicable 7th characters. The applicable 7th character is required for all codes within the category, or as the notes in the Tabular List instruct. The 7th character must always be the 7th character in the data field. If a code that requires a 7th character is not 6 characters, a placeholder X must be used to fill in the empty characters.
  • With - The word "with" should be interpreted to mean "associated with" or "due to" when it appears in a code title, the Alphabetic Index, or an instructional note in the Tabular List. The word "with" in the Alphabetic Index is sequenced immediately following the main term, not in alphabetical order.