2026 ICD-10-CM Diagnosis Code D75.81Myelofibrosis

ICD-10-CM Codes›D50–D89›D70-D77›D75

ICD-10-CM D75.81
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D75.81 is a billable ICD-10-CM diagnosis code for myelofibrosis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 820 through 825, 840 through 842. The code is a manifestation code that cannot be reported as the principal diagnosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified hematologic conditions.

Code Identity

ICD-10-CM Code
D75.81
Billable Status
Yes — Valid for Submission
Code Describes
Myelofibrosis
Short Description
Myelofibrosis
Same as the full description in the CMS dataset.
Parent Code
D75.8
Other specified diseases of blood and blood-forming organs

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD75Other and unspecified diseases of blood and blood-forming organs
This CodeD75.81Myelofibrosis

Code EditsBilling

Medicare Code Editor checks that affect claim validity for D75.81.

Manifestation diagnoses
Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and therefore should not be used as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Congenital neutropenia, myelofibrosis, nephromegaly syndrome
  • Hereditary thrombocytopenia with early-onset myelofibrosis
  • Ischemic myelofibrosis
  • Myelofibrosis
  • Myelofibrosis caused by drug
  • Myelofibrosis due to another disorder
  • Post-essential thrombocythemia myelofibrosis
  • Post-polycythemia vera myelofibrosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Myelofibrosis NOS
  • Secondary myelofibrosis NOS

Code First

  • the underlying disorder, such as:
  • malignant neoplasm of breast C50

Use Additional Code

  • code, if applicable, for associated therapy-related myelodysplastic syndrome D46

Type 1 Excludes

  • acute myelofibrosis C94.4
  • idiopathic myelofibrosis D47.1
  • leukoerythroblastic anemia D61.82
  • myelofibrosis with myeloid metaplasia D47.4
  • myelophthisic anemia D61.82
  • myelophthisis D61.82
  • primary myelofibrosis D47.1

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • myelofibrosis
    • Myelofibrosis
    • Myelofibrosis
      • secondary
    • Osteosclerosis
      • myelofibrosis

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD010
Other specified and unspecified hematologic conditions
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Bone Marrow Diseases

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D75.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
289.83 Myelofibrosis
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D75.81Overview

Is D75.81 (Other specified diseases of blood and blood-forming organs) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report myelofibrosis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D75.81 group to?

On inpatient claims, myelofibrosis maps to MS-DRG 820, 821, 822, 823, 824, 825, 840, 841, 842, with relative weights from 1.0104 to 5.8648 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D75.81 be a principal diagnosis?

No. This is a manifestation code: myelofibrosis describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.

What is the ICD-9 equivalent of D75.81?

Under the General Equivalence Mappings, myelofibrosis converts to ICD-9-CM 289.83 (myelofibrosis). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.