2026 ICD-10-CM Diagnosis Code D70.1Agranulocytosis secondary to cancer chemotherapy

ICD-10-CM Codes›D50–D89›D70-D77›D70

ICD-10-CM D70.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D70.1 is a billable ICD-10-CM diagnosis code for agranulocytosis secondary to cancer chemotherapy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. Coders also document this condition as agranulocytosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Conditions due to neoplasm or the treatment of neoplasm and Diseases of white blood cells.

Code Identity

ICD-10-CM Code
D70.1
Billable Status
Yes — Valid for Submission
Code Describes
Agranulocytosis secondary to cancer chemotherapy
Short Description
Agranulocytosis secondary to cancer chemotherapy
Same as the full description in the CMS dataset.
Parent Code
D70
Neutropenia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD70Neutropenia
This CodeD70.1Agranulocytosis secondary to cancer chemotherapy

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Agranulocytosis
  • Agranulocytosis due to and following administration of antineoplastic agent
  • Neutropenia due to and following chemotherapy

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Code Also

  • underlying neoplasm

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T45.1X5

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Agranulocytosis(chronic) (cyclical) (genetic) (infantile) (periodic) (pernicious)
      • cytoreductive cancer chemotherapy sequela
    • Agranulocytosis(chronic) (cyclical) (genetic) (infantile) (periodic) (pernicious)
      • drug-induced
        • due to cytoreductive cancer chemotherapy
    • Agranulocytosis(chronic) (cyclical) (genetic) (infantile) (periodic) (pernicious)
      • secondary
        • drug-induced
          • due to cytoreductive cancer chemotherapy
    • Leukopenia
      • chemotherapy (cancer) induced
    • Leukopenia
      • drug induced NEC
        • due to cytoreductive cancer chemotherapy
    • Neutropenia, neutropenic(chronic) (genetic) (idiopathic) (immune) (infantile) (malignant) (pernicious) (splenic)
      • cytoreductive cancer chemotherapy sequela
    • Neutropenia, neutropenic(chronic) (genetic) (idiopathic) (immune) (infantile) (malignant) (pernicious) (splenic)
      • drug-induced
        • due to cytoreductive cancer chemotherapy
    • Neutropenia, neutropenic(chronic) (genetic) (idiopathic) (immune) (infantile) (malignant) (pernicious) (splenic)
      • secondary (cyclic) (periodic) (splenic)
        • drug-induced
          • due to cytoreductive cancer chemotherapy

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO074
Conditions due to neoplasm or the treatment of neoplasm
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Agranulocytosis

    a decrease in the number of granulocytes; (basophils; eosinophils; and neutrophils).

  • Feline Panleukopenia

    a highly contagious dna virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. it is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. it is caused by feline panleukopenia virus or the closely related mink enteritis virus or canine parvovirus.

  • Agranulocytosis

    a marked decrease in the number of mature granulocytes (most often neutrophils) in the peripheral blood.

  • Chemotherapy Related Agranulocytosis|Chemotherapy-Related Agranulocytosis

    agranulocytosis that occurs with chemotherapy.

  • Congenital Neutropenia|congenital neutropenia|genetic infantile agranulocytosis|infantile genetic agranulocytosis

    a rare congenital disorder characterized by mild or severe reduction of neutrophils in the peripheral blood and recurrent infantile infections.

  • Cyclic Neutropenia|CH|CN|Cyclic Agranulocytosis|Cyclic Hematopoiesis|Cyclic Hematopoiesis|Dysplasia, Myelocytic Periodic|Periodic Neutropenia|cyclic neutropenia|periodic neutropenia

    a hematologic disorder caused by a mutation in the elane (ela2) gene; clinical manifestations include recurrent neutropenia with resultant susceptibility to infection leading to fever.

Patient EducationClinical

Blood Disorders

Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D70.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
288.03 Drug induced neutropenia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D70.1Overview

Is D70.1 (Neutropenia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report agranulocytosis secondary to cancer chemotherapy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D70.1 group to?

When agranulocytosis secondary to cancer chemotherapy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D70.1?

Under the General Equivalence Mappings, agranulocytosis secondary to cancer chemotherapy converts to ICD-9-CM 288.03 (drug induced neutropenia). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.