2026 ICD-10-CM Diagnosis Code D69.42Congenital and hereditary thrombocytopenia purpura

ICD-10-CM Codes›D50–D89›D65-D69›D69

ICD-10-CM D69.42
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D69.42 is a billable ICD-10-CM diagnosis code for congenital and hereditary thrombocytopenia purpura. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coagulation and hemorrhagic disorders.

Code Identity

ICD-10-CM Code
D69.42
Billable Status
Yes — Valid for Submission
Code Describes
Congenital and hereditary thrombocytopenia purpura
Short Description
Congenital and hereditary thrombocytopenia purpura
Same as the full description in the CMS dataset.
Parent Code
D69.4
Other primary thrombocytopenia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD65-D69Coagulation defects, purpura and other hemorrhagic conditions
CategoryD69Purpura and other hemorrhagic conditions
This CodeD69.42Congenital and hereditary thrombocytopenia purpura

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Amegakaryocytic thrombocytopenia
  • Amegakaryocytic thrombocytopenia with congenital malformation
  • Autosomal dominant macrothrombocytopenia
  • Autosomal dominant thrombocytopenia with platelet secretion defect
  • Beta thalassemia X-linked thrombocytopenia syndrome
  • Bleeding diathesis due to thromboxane synthesis deficiency
  • Congenital amegakaryocytic thrombocytopenia
  • Congenital autosomal recessive small-platelet thrombocytopenia
  • Congenital dyserythropoietic anemia
  • Congenital radioulnar synostosis
  • Congenital thrombocytopenia
  • DIAPH1-related sensorineural hearing loss-thrombocytopenia syndrome
  • GATA binding protein 1 related thrombocytopenia with dyserythropoiesis
  • Giant platelet syndrome
  • Hereditary thrombocytopenia with early-onset myelofibrosis
  • Hereditary thrombocytopenia with normal platelets
  • Hereditary thrombocytopenic disorder
  • Macrothrombocytopenia, lymphedema, developmental delay, facial dysmorphism, camptodactyly syndrome
  • Megakaryocytic thrombocytopenia
  • Multifocal lymphangioendotheliomatosis, thrombocytopenia syndrome
  • MYH9 related disease
  • Platelet secretory disorder
  • Radioulnar synostosis with amegakaryocytic thrombocytopenia syndrome
  • Secondary thrombocytopenia
  • Severe autosomal recessive macrothrombocytopenia
  • Sex-linked thrombocytopenia
  • Thrombotic thrombocytopenic purpura
  • Upshaw-Schulman syndrome
  • X-linked congenital dyserythropoietic anemia with thrombocytopenia
  • X-linked thrombocytopenia with normal platelets

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Congenital thrombocytopenia
  • Hereditary thrombocytopenia

Code First

  • congential or hereditary disorder, such as:
  • thrombocytopenia with absent radius TAR syndrome Q87.2

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Purpura
      • thrombocytopenic
        • congenital
    • Purpura
      • thrombocytopenic
        • hereditary
    • Thrombocytopenia, thrombocytopenic
      • congenital
    • Thrombocytopenia, thrombocytopenic
      • hereditary

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD006
Coagulation and hemorrhagic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • CDAN1 Gene|CDAN1|CDAN1|Congenital Dyserythropoietic Anemia, Type I Gene

    this gene may be involved in nuclear membrane maintenance.

  • CDAN1 wt Allele|CDA-I|CDA1|CDAI|Codanin Gene|Congenital Dyserythropoietic Anemia, Type I wt Allele|DLT|Discs Lost Homolog Gene|Discs Lost, Drosophila, Homolog of Gene|PRO1295|UNQ664/PRO1295

    human cdan1 wild-type allele is located in the vicinity of 15q15.2 and is approximately 14 kb in length. this allele, which encodes codanin-1 protein, may play a role in the maintenance of the nuclear envelope. mutation of the gene is associated with congenital dyserythropoietic anemia type i.

  • Congenital Dyserythropoietic Anemia

    a rare group of disorders that result in anemia that is caused by ineffective erythropoiesis, which is associated with multinuclear erythroblasts, and which may present in childhood. the most common mutations are in the cdan1 and sec23b genes.

  • Congenital Dyserythropoietic Anemia Type II|CDA II|CDAN2|HEMPAS|Hereditary Erythroblastic Multinuclearity with Positive Acidified-Serum Test|SEC23B-CDG

    an autosomal recessive subtype of congenital dyserythropoietic anemia caused by mutation(s) in the sec23b gene, encoding protein transport protein sec23b.

  • Congenital Dyserythropoietic Anemia Type IV|CDAN4

    an autosomal dominant sub-type of congenital dyserythropoietic anemia caused by mutation(s) in the klf1 gene, encoding krueppel-like factor 1.

  • SEC23B wt Allele|CDA-II|CDAII|CDAN2|Congenital Dyserythropoietic Anemia, Type II Gene|HEMPAS|RP11-379J5.1|Sec23 Homolog B (S. cerevisiae) wt Allele

    human sec23b wild-type allele is located in the vicinity of 20p11.23 and is approximately 54 kb in length. this allele, which encodes protein transport protein sec23b, is involved in the transport of vesicles from the endoplasmic reticulum to the golgi. mutation of the gene is associated with congenital dyserythropoietic anemia type ii.

  • Congenital Amegakaryocytic Thrombocytopenia

    a rare, autosomal recessive inherited disorder caused by mutation in the c-mpl gene. it is characterized by thrombocytopenia and absence of megakaryocytes. it presents with bleeding in the first month of life.

Patient EducationClinical

Platelet Disorders

Platelets, also known as thrombocytes, are blood cells. They form in your bone marrow, a sponge-like tissue in your bones. Platelets play a major role in blood clotting. Normally, when one of your blood vessels is injured, you start to bleed.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D69.42 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
287.33 Cong/herid thromb purpra
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D69.42Overview

Is D69.42 (Other primary thrombocytopenia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report congenital and hereditary thrombocytopenia purpura on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of D69.42?

Under the General Equivalence Mappings, congenital and hereditary thrombocytopenia purpura converts to ICD-9-CM 287.33 (cong/herid thromb purpra). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.