2026 ICD-10-CM Diagnosis Code D61.1Drug-induced aplastic anemia

ICD-10-CM Codes›D50–D89›D60-D64›D61

ICD-10-CM D61.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D61.1 is a billable ICD-10-CM diagnosis code for drug-induced aplastic anemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. Coders also document this condition as anemia caused by antineoplastic agent. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Aplastic anemia and Drug induced or toxic related condition.

Code Identity

ICD-10-CM Code
D61.1
Billable Status
Yes — Valid for Submission
Code Describes
Drug-induced aplastic anemia
Short Description
Drug-induced aplastic anemia
Same as the full description in the CMS dataset.
Parent Code
D61
Other aplastic anemias and other bone marrow failure syndromes

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD60-D64Aplastic and other anemias and other bone marrow failure syndromes
CategoryD61Other aplastic anemias and other bone marrow failure syndromes
This CodeD61.1Drug-induced aplastic anemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Anemia caused by antineoplastic agent
  • Aplastic anemia caused by antineoplastic agent
  • Aplastic anemia due to drugs
  • Drug-induced hypoplasia of bone marrow
  • Hypocellular bone marrow
  • Pancytopenia caused by medication
  • Secondary aplastic anemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • aplastic
        • drug-induced
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • aplastic
        • due to
          • drugs

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD003
Aplastic anemia
Default principal diagnosis: inpatient No · outpatient No
CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Aplastic Anemia

Aplastic anemia is a rare but serious blood disorder. If you have it, your bone marrow doesn't make enough new blood cells. It happens when there is damage to stem cells inside your bone marrow. There are different types of aplastic anemia, including Fanconi anemia.

The full article covers:

  • What is aplastic anemia?
  • What causes aplastic anemia?
  • What are the symptoms of aplastic anemia?
  • What other problems can aplastic anemia cause?
  • How is aplastic anemia diagnosed?
  • What are the treatments for aplastic anemia?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D61.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
284.89 Aplastic anemias NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D61.1Overview

Is D61.1 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced aplastic anemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D61.1 group to?

When drug-induced aplastic anemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D61.1?

Under the General Equivalence Mappings, drug-induced aplastic anemia converts to ICD-9-CM 284.89 (aplastic anemias NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.