Other aplastic anemias and other bone marrow failure syndromes (D61) ICD-10-CM
The D61 code range covers other aplastic anemias and other bone marrow failure syndromes with 17 ICD-10-CM diagnosis codes. 13 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- neutropenia D70
Codes in the D61 Range 17 codes · 13 billable
- D61 Other aplastic anemias and other bone marrow failure syndromesNon-billable
- D61.0 Constitutional aplastic anemiaNon-billable
- D61.01 Constitutional (pure) red blood cell aplasia
- D61.02 Shwachman-Diamond syndrome
- D61.03 Fanconi anemia
- D61.09 Other constitutional aplastic anemia
- D61.1 Drug-induced aplastic anemia
- D61.2 Aplastic anemia due to other external agents
- D61.3 Idiopathic aplastic anemia
- D61.8 Other specified aplastic anemias and other bone marrow failure syndromesNon-billable
- D61.81 PancytopeniaNon-billable
- D61.810 Antineoplastic chemotherapy induced pancytopenia
- D61.811 Other drug-induced pancytopenia
- D61.818 Other pancytopenia
- D61.82 Myelophthisis
- D61.89 Other specified aplastic anemias and other bone marrow failure syndromes
- D61.9 Aplastic anemia, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D61 range.
BRCA2 Protein
A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)
Fanconi Anemia Complementation Group A Protein
A Fanconi anemia complementation group protein that is the most commonly mutated protein in FANCONI ANEMIA. It undergoes PHOSPHORYLATION by PROTEIN KINASE B and forms a complex with FANCC PROTEIN in the CELL NUCLEUS.
Fanconi Anemia Complementation Group C Protein
A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.
Fanconi Anemia Complementation Group D2 Protein
A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.
Fanconi Anemia Complementation Group E Protein
A Fanconi anemia complementation group protein that interacts with FANCC PROTEIN and FANCD2 PROTEIN. It promotes the accumulation of FANCC protein in the CELL NUCLEUS.
Fanconi Anemia Complementation Group F Protein
A Fanconi anemia complementation group protein. It is an essential component of a nuclear core complex that protects the GENOME against CHROMOSOMAL INSTABILITY. It interacts directly with FANCG PROTEIN and helps stabilize a complex with FANCA PROTEIN and FANCC PROTEIN.
Fanconi Anemia Complementation Group G Protein
A Fanconi anemia complementation group protein that undergoes PHOSPHORYLATION by CDC2 PROTEIN KINASE during MITOSIS. It forms a complex with other FANCONI ANEMIA PROTEINS and helps protect CELLS from DNA DAMAGE by genotoxic agents.
Fanconi Anemia Complementation Group L Protein
An E3 UBIQUITIN LIGASE that plays a key role in the DNA damage response pathway of FANCONI ANEMIA PROTEINS. It is associated with mono-ubiquitination of FANCD2 PROTEIN and the redistribution of FANCD2 to nuclear foci containing BRCA1 PROTEIN.
Fanconi Anemia Complementation Group N Protein
A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
Fanconi Anemia Complementation Group Proteins
A diverse group of proteins whose genetic MUTATIONS have been associated with the chromosomal instability syndrome FANCONI ANEMIA. Many of these proteins play important roles in protecting CELLS against OXIDATIVE STRESS.
Pancytopenia
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
About the D61 Code Range
The D61 ICD-10 codes classify various types of aplastic anemias and bone marrow failure syndromes characterized by the bone marrow's inability to produce sufficient blood cells. These codes are used to identify specific causes and forms of these failures, from inherited conditions like Fanconi anemia (D61.03) to drug-induced cases such as D61.1, as well as other pancytopenias and marrow disorders.
This section includes unique diagnoses like constitutional aplastic anemia (D61.0) and its subtypes, including pure red cell aplasia (D61.01), also known as erythroid hypoplasia or hypoplastic anemia. Syndromes such as Shwachman-Diamond syndrome (D61.02) and hereditary forms like Fanconi anemia are distinctly coded. The codes D61.1 and D61.2 cover aplastic anemia caused by drugs or other external agents like radiation or infections. Idiopathic or acquired cases fall under D61.3. Pancytopenia, a condition of decreased blood cell counts, is coded in the D61.8 range, indicating causes from chemotherapy (D61.810) to autoimmune origins (D61.818). This comprehensive coding helps clinicians and coders accurately document and differentiate aplastic anemias and marrow failure syndromes for precise treatment and record-keeping.
Questions About This Page
How many billable codes are in the D61 range?
Of the 17 codes in this range, 13 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the D61 range classify?
The range classifies other aplastic anemias and other bone marrow failure syndromes. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
