2026 ICD-10-CM Diagnosis Code Z15.09Genetic susceptibility to other malignant neoplasm

ICD-10-CM Codes›Z00–Z99›Z14-Z15›Z15

ICD-10-CM Z15.09
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z15.09 is a billable ICD-10-CM diagnosis code for genetic susceptibility to other malignant neoplasm. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genetic susceptibility to disease.

Code Identity

ICD-10-CM Code
Z15.09
Billable Status
Yes — Valid for Submission
Code Describes
Genetic susceptibility to other malignant neoplasm
Short Description
Genetic susceptibility to other malignant neoplasm
Same as the full description in the CMS dataset.
Parent Code
Z15.0
Genetic susceptibility to malignant neoplasm

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ14-Z15Genetic carrier and genetic susceptibility to disease
CategoryZ15Genetic susceptibility to disease
This CodeZ15.09Genetic susceptibility to other malignant neoplasm

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z15.09.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z15.09 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • BAP1 tumor predisposition syndrome
  • Combined immunodeficiency due to CARMIL2 deficiency
  • Combined immunodeficiency due to CD70 deficiency
  • DDX41-related hematologic malignancy predisposition syndrome
  • DICER1 syndrome
  • Familial cutaneous telangiectasia and oropharyngeal cancer predisposition syndrome
  • Genetic susceptibility to cancer
  • Hereditary cancer-predisposing syndrome
  • Hereditary non-polyposis colon cancer gene mutation detected
  • Hereditary well-differentiated neuroendocrine tumor of small intestine
  • Inherited cancer-predisposing syndrome due to biallelic BRCA2 mutation
  • Lynch syndrome
  • Macroencephaly
  • Megalencephaly capillary malformation
  • MITF-related melanoma and renal cell carcinoma predisposition syndrome
  • Mosaic variegated aneuploidy syndrome
  • Palmoplantar keratoderma, 46,XX sex reversal, predisposition to squamous cell carcinoma syndrome
  • Progeroid features, hepatocellular carcinoma predisposition syndrome
  • Rhabdoid tumor predisposition syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Genetic
      • susceptibility to disease NEC
        • malignant neoplasm
    • Genetic
      • susceptibility to disease NEC
        • malignant neoplasm
          • specified NEC
    • Susceptibility to disease, genetic
      • malignant neoplasm
    • Susceptibility to disease, genetic
      • malignant neoplasm
        • specified NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC029
Genetic susceptibility to disease
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • DICER1 Syndrome

    a rare, autosomal dominant inherited syndrome caused by mutations in the dicer1 gene. people with this syndrome are at an increased risk of developing pleuropulmonary blastoma, cystic nephroma, sertoli-leydig cell tumor of the ovary, and multinodular goiter.

Convert Z15.09 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V84.09 Genetic susc mal neo NEC
Exact Match The mapping is direct, with no qualifiers.

Code History & ChangesHistory

Replaced This code was replaced in the FY 2026 code set by:

  • Z15.05 - Genetic susceptibility to malignant neoplasm of fallop(s)
  • Z15.060 - Genetic susceptibility to colorectal cancer
  • Z15.068 - Genetic susceptibility to other malig neoplasm of dgstv sys
  • Z15.07 - Genetic susceptibility to malig neoplasm of urinary tract
FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z15.09Overview

Is Z15.09 (Genetic susceptibility to malignant neoplasm) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report genetic susceptibility to other malignant neoplasm on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z15.09 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because genetic susceptibility to other malignant neoplasm describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z15.09 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for genetic susceptibility to other malignant neoplasm on inpatient claims.

What is the ICD-9 equivalent of Z15.09?

Under the General Equivalence Mappings, genetic susceptibility to other malignant neoplasm converts to ICD-9-CM V84.09 (genetic susc mal neo NEC). The mapping is a direct match.