ICD-10-CM Code Z16

Resistance to antimicrobial drugs

Version 2020 Non-Billable Code

Not Valid for Submission

Z16 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of resistance to antimicrobial drugs. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10:Z16
Short Description:Resistance to antimicrobial drugs
Long Description:Resistance to antimicrobial drugs

Consider the following ICD-10 codes with a higher level of specificity:

  • Z16.1 - Resistance to beta lactam antibiotics
  • Z16.10 - Resistance to unspecified beta lactam antibiotics
  • Z16.11 - Resistance to penicillins
  • Z16.12 - Extended spectrum beta lactamase (ESBL) resistance
  • Z16.19 - Resistance to other specified beta lactam antibiotics
  • Z16.2 - Resistance to other antibiotics
  • Z16.20 - Resistance to unspecified antibiotic
  • Z16.21 - Resistance to vancomycin
  • Z16.22 - Resistance to vancomycin related antibiotics
  • Z16.23 - Resistance to quinolones and fluoroquinolones
  • Z16.24 - Resistance to multiple antibiotics
  • Z16.29 - Resistance to other single specified antibiotic
  • Z16.3 - Resistance to other antimicrobial drugs
  • Z16.30 - Resistance to unspecified antimicrobial drugs
  • Z16.31 - Resistance to antiparasitic drug(s)
  • Z16.32 - Resistance to antifungal drug(s)
  • Z16.33 - Resistance to antiviral drug(s)
  • Z16.34 - Resistance to antimycobacterial drug(s)
  • Z16.341 - Resistance to single antimycobacterial drug
  • Z16.342 - Resistance to multiple antimycobacterial drugs
  • Z16.35 - Resistance to multiple antimicrobial drugs
  • Z16.39 - Resistance to other specified antimicrobial drug

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code Z16:

Code First

Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • the infection

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Methicillin resistant Staphylococcus aureus infection A49.02
  • Methicillin resistant Staphylococcus aureus pneumonia J15.212
  • Sepsis due to Methicillin resistant Staphylococcus aureus A41.02

  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Code Classification

  • Factors influencing health status and contact with health services (Z00–Z99)
    • Resistance to antimicrobial drugs (Z16)
      • Resistance to antimicrobial drugs (Z16)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Antibiotic Resistance

Antibiotics are medicines that fight bacterial infections. Used properly, they can save lives. But there is a growing problem of antibiotic resistance. It happens when bacteria change and become able to resist the effects of an antibiotic.

Using antibiotics can lead to resistance. Each time you take antibiotics, sensitive bacteria are killed. But resistant germs may be left to grow and multiply. They can spread to other people. They can also cause infections that certain antibiotics cannot cure. Methicillin-resistant Staphylococcus aureus (MRSA) is one example. It causes infections that are resistant to several common antibiotics.

To help prevent antibiotic resistance

  • Don't use antibiotics for viruses like colds or flu. Antibiotics don't work on viruses.
  • Don't pressure your doctor to give you an antibiotic.
  • When you take antibiotics, follow the directions carefully. Finish your medicine even if you feel better. If you stop treatment too soon, some bacteria may survive and re-infect you.
  • Don't save antibiotics for later or use someone else's prescription.

Centers for Disease Control and Prevention


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