ICD-10 Diagnosis Code Z15.89

Genetic susceptibility to other disease

Diagnosis Code Z15.89

ICD-10: Z15.89
Short Description: Genetic susceptibility to other disease
Long Description: Genetic susceptibility to other disease
This is the 2019 version of the ICD-10-CM diagnosis code Z15.89

Valid for Submission
The code Z15.89 is valid for submission for HIPAA-covered transactions.

Code Classification
  • Factors influencing health status and contact with health services (Z00–Z99)
    • Genetic carrier and genetic susceptibility to disease (Z14-Z15)
      • Genetic susceptibility to disease (Z15)
Version 2019 Billable Code Unacceptable Principal Diagnosis POA Exempt

Information for Medical Professionals


Code Edits
The following edits are applicable to this code:
Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual’s health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Convert to ICD-9
  • V84.89 - Genetic suscept dis NEC

Present on Admission (POA)
The code Z15.89 is exempt from POA reporting.

Synonyms
  • At risk for heritable disorder
  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency
  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Dense body defect
  • Familial platelet syndrome with predisposition to acute myelogenous leukemia
  • Genetic susceptibility to genetic disorder
  • Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 1 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 2 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interleukin 12 receptor beta 1 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interleukin 12 subunit beta deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete ISG15 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial IRF8 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial STAT1 deficiency
  • X-linked mendelian susceptibility to mycobacterial disease

Index to Diseases and Injuries
References found for the code Z15.89 in the Index to Diseases and Injuries:


Information for Patients


Genetic Disorders

Genes are the building blocks of heredity. They are passed from parent to child. They hold DNA, the instructions for making proteins. Proteins do most of the work in cells. They move molecules from one place to another, build structures, break down toxins, and do many other maintenance jobs.

Sometimes there is a mutation, a change in a gene or genes. The mutation changes the gene's instructions for making a protein, so the protein does not work properly or is missing entirely. This can cause a medical condition called a genetic disorder.

You can inherit a gene mutation from one or both parents. A mutation can also happen during your lifetime.

There are three types of genetic disorders:

  • Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example.
  • Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. Chromosomes are the structures that hold our genes. Down syndrome is a chromosomal disorder.
  • Complex disorders, where there are mutations in two or more genes. Often your lifestyle and environment also play a role. Colon cancer is an example.

Genetic tests on blood and other tissue can identify genetic disorders.

NIH: National Library of Medicine

  • Genetics (Medical Encyclopedia)

[Read More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.

Present on Admission
The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement.

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