ICD-10-CM Code Z15.89

Genetic susceptibility to other disease

Version 2020 Billable Code Unacceptable Principal Diagnosis POA Exempt

Valid for Submission

Z15.89 is a billable code used to specify a medical diagnosis of genetic susceptibility to other disease. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code Z15.89 might also be used to specify conditions or terms like at risk for heritable disorder, autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency, autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency, autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency, dense body defect, familial platelet syndrome with predisposition to acute myelogenous leukemia, etc The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

The code Z15.89 describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

ICD-10:Z15.89
Short Description:Genetic susceptibility to other disease
Long Description:Genetic susceptibility to other disease

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code Z15.89 are found in the index:


Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10 Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual’s health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • At risk for heritable disorder
  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency
  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Dense body defect
  • Familial platelet syndrome with predisposition to acute myelogenous leukemia
  • Genetic susceptibility to genetic disorder
  • Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 1 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 2 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interleukin 12 receptor beta 1 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interleukin 12 subunit beta deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete ISG15 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial IRF8 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial STAT1 deficiency
  • X-linked mendelian susceptibility to mycobacterial disease

Present on Admission (POA)

Z15.89 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here .

CMS POA Indicator Options and Definitions
POA Indicator CodePOA Reason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert Z15.89 to ICD-9

  • V84.89 - Genetic suscept dis NEC

Code Classification

  • Factors influencing health status and contact with health services (Z00–Z99)
    • Genetic carrier and genetic susceptibility to disease (Z14-Z15)
      • Genetic susceptibility to disease (Z15)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Genetic Disorders

Genes are the building blocks of heredity. They are passed from parent to child. They hold DNA, the instructions for making proteins. Proteins do most of the work in cells. They move molecules from one place to another, build structures, break down toxins, and do many other maintenance jobs.

Sometimes there is a mutation, a change in a gene or genes. The mutation changes the gene's instructions for making a protein, so the protein does not work properly or is missing entirely. This can cause a medical condition called a genetic disorder.

You can inherit a gene mutation from one or both parents. A mutation can also happen during your lifetime.

There are three types of genetic disorders:

  • Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example.
  • Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. Chromosomes are the structures that hold our genes. Down syndrome is a chromosomal disorder.
  • Complex disorders, where there are mutations in two or more genes. Often your lifestyle and environment also play a role. Colon cancer is an example.

Genetic tests on blood and other tissue can identify genetic disorders.

NIH: National Library of Medicine


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