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  5. Resistance to antimicrobial drugs (Z16)

Resistance to antimicrobial drugs (Z16)

    • ICD-10 Index

      • Factors influencing health status and contact with health services (Z00–Z99)

        • Resistance to antimicrobial drugs (Z16)

            • Resistance to antimicrobial drugs (Z16)
            • Z16 - Resistance to antimicrobial drugs NON-BILLABLE CODE
            • Z16.1 - Resistance to beta lactam antibiotics NON-BILLABLE CODE
            • Z16.10 - Resistance to unspecified beta lactam antibiotics BILLABLE CODE
            • Z16.11 - Resistance to penicillins BILLABLE CODE
            • Z16.12 - Extended spectrum beta lactamase (ESBL) resistance BILLABLE CODE
            • Z16.19 - Resistance to other specified beta lactam antibiotics BILLABLE CODE
            • Z16.2 - Resistance to other antibiotics NON-BILLABLE CODE
            • Z16.20 - Resistance to unspecified antibiotic BILLABLE CODE
            • Z16.21 - Resistance to vancomycin BILLABLE CODE
            • Z16.22 - Resistance to vancomycin related antibiotics BILLABLE CODE
            • Z16.23 - Resistance to quinolones and fluoroquinolones BILLABLE CODE
            • Z16.24 - Resistance to multiple antibiotics BILLABLE CODE
            • Z16.29 - Resistance to other single specified antibiotic BILLABLE CODE
            • Z16.3 - Resistance to other antimicrobial drugs NON-BILLABLE CODE
            • Z16.30 - Resistance to unspecified antimicrobial drugs BILLABLE CODE
            • Z16.31 - Resistance to antiparasitic drug(s) BILLABLE CODE
            • Z16.32 - Resistance to antifungal drug(s) BILLABLE CODE
            • Z16.33 - Resistance to antiviral drug(s) BILLABLE CODE
            • Z16.34 - Resistance to antimycobacterial drug(s) NON-BILLABLE CODE
            • Z16.341 - Resistance to single antimycobacterial drug BILLABLE CODE
            • Z16.342 - Resistance to multiple antimycobacterial drugs BILLABLE CODE
            • Z16.35 - Resistance to multiple antimicrobial drugs BILLABLE CODE
            • Z16.39 - Resistance to other specified antimicrobial drug BILLABLE CODE

Clinical Information for Resistance to antimicrobial drugs (Z16)

Drug Resistance - Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

Drug Resistance, Bacterial - The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Drug Resistance, Fungal - The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.

Drug Resistance, Microbial - The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Drug Resistance, Multiple - Simultaneous resistance to several structurally and functionally distinct drugs.

Drug Resistance, Multiple, Bacterial - The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Drug Resistance, Multiple, Fungal - The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.

Drug Resistance, Multiple, Viral - The ability of viruses to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutation.

Drug Resistance, Neoplasm - Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

Drug Resistance, Viral - The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.

Drug Resistance - Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

Drug Resistance, Bacterial - The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Drug Resistance, Fungal - The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.

Drug Resistance, Microbial - The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Drug Resistance, Multiple - Simultaneous resistance to several structurally and functionally distinct drugs.

Drug Resistance, Multiple, Bacterial - The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Drug Resistance, Multiple, Fungal - The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.

Drug Resistance, Multiple, Viral - The ability of viruses to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutation.

Drug Resistance, Neoplasm - Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

Drug Resistance, Viral - The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.

Drug Tolerance - Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.

Drug Tolerance - Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.

Instructional Notations

Code First Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.

  • the infection

Type 1 Excludes Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

  • Methicillin resistant Staphylococcus aureus infection A49.02
  • Methicillin resistant Staphylococcus aureus pneumonia J15.212
  • Sepsis due to Methicillin resistant Staphylococcus aureus A41.02

  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.