Resistance to antimicrobial drugs (Z16) ICD-10-CM
The Z16 code range covers resistance to antimicrobial drugs with 24 ICD-10-CM diagnosis codes. 19 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
- the infection
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- Methicillin resistant Staphylococcus aureus infection A49.02
- Methicillin resistant Staphylococcus aureus pneumonia J15.212
- Sepsis due to Methicillin resistant Staphylococcus aureus A41.02
- The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
Codes in the Z16 Range 24 codes · 19 billable
- Z16 Resistance to antimicrobial drugsNon-billable
- Z16.1 Resistance to beta lactam antibioticsNon-billable
- Z16.10 Resistance to unspecified beta lactam antibiotics
- Z16.11 Resistance to penicillins
- Z16.12 Extended spectrum beta lactamase (ESBL) resistance
- Z16.13 Resistance to carbapenem
- Z16.19 Resistance to other specified beta lactam antibiotics
- Z16.2 Resistance to other antibioticsNon-billable
- Z16.20 Resistance to unspecified antibiotic
- Z16.21 Resistance to vancomycin
- Z16.22 Resistance to vancomycin related antibiotics
- Z16.23 Resistance to quinolones and fluoroquinolones
- Z16.24 Resistance to multiple antibiotics
- Z16.29 Resistance to other single specified antibiotic
- Z16.3 Resistance to other antimicrobial drugsNon-billable
- Z16.30 Resistance to unspecified antimicrobial drugs
- Z16.31 Resistance to antiparasitic drug(s)
- Z16.32 Resistance to antifungal drug(s)
- Z16.33 Resistance to antiviral drug(s)
- Z16.34 Resistance to antimycobacterial drug(s)Non-billable
- Z16.341 Resistance to single antimycobacterial drug
- Z16.342 Resistance to multiple antimycobacterial drugs
- Z16.35 Resistance to multiple antimicrobial drugs
- Z16.39 Resistance to other specified antimicrobial drug
About the Z16 Code Range
Antimicrobial drug resistance includes resistance to antibiotics and to other antimicrobial drugs.
Z16 separates resistance to beta lactam antibiotics (Z16.1), other antibiotics (Z16.2), and other antimicrobial drugs (Z16.3).
Questions About This Page
How many billable codes are in the Z16 range?
Of the 24 codes in this range, 19 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the Z16 range classify?
The range classifies resistance to antimicrobial drugs. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.