• Genetic
    • carrier (status)
      • cystic fibrosis - Z14.1 Cystic fibrosis carrier
      • hemophilia A (asymptomatic) - Z14.01 Asymptomatic hemophilia A carrier
        • symptomatic - Z14.02 Symptomatic hemophilia A carrier
      • specified NEC - Z14.8 Genetic carrier of other disease
    • susceptibility to disease NEC - Z15.89 Genetic susceptibility to other disease
      • malignant neoplasm - Z15.09 Genetic susceptibility to other malignant neoplasm
        • breast - Z15.01 Genetic susceptibility to malignant neoplasm of breast
        • endometrium - Z15.04 Genetic susceptibility to malignant neoplasm of endometrium
        • ovary - Z15.02 Genetic susceptibility to malignant neoplasm of ovary
        • prostate - Z15.03 Genetic susceptibility to malignant neoplasm of prostate
        • specified NEC - Z15.09 Genetic susceptibility to other malignant neoplasm
      • multiple endocrine neoplasia - Z15.81 Genetic susceptibility to multiple endocrine neoplasia [MEN]


Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.

Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Endometrium: The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.

Multiple Endocrine Neoplasia: A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.

Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.

Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.

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