2026 ICD-10-CM Diagnosis Code Z15Genetic susceptibility to disease

ICD-10-CM Codes›Z00–Z99›Z14-Z15›Z15

ICD-10-CM Z15
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z15 is a non-billable ICD-10-CM category code for genetic susceptibility to disease, so it cannot be submitted on claims. Use a more specific code from this category instead, such as Z15.01, Z15.02, Z15.03, and Z15.04.

Code Identity

ICD-10-CM Code
Z15
Billable Status
No — Non-Billable Category
Code Describes
Genetic susceptibility to disease
Chapter
Z14-Z15
Genetic carrier and genetic susceptibility to disease

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ14-Z15Genetic carrier and genetic susceptibility to disease
CategoryZ15Genetic susceptibility to disease
This CodeZ15Genetic susceptibility to disease

Specific Coding for Genetic susceptibility to diseaseOverview

Non-specific codes like Z15 require more characters. Use one of these billable codes instead:

  • Z15.0 for Genetic susceptibility to malignant neoplasm

  • Use Z15.01 for Genetic susceptibility to malignant neoplasm of breast

  • Use Z15.02 for Genetic susceptibility to malignant neoplasm of ovary

  • Use Z15.03 for Genetic susceptibility to malignant neoplasm of prostate

  • Use Z15.04 for Genetic susceptibility to malignant neoplasm of endometrium

  • Use Z15.05 for Genetic susceptibility to malignant neoplasm of fallopian tube(s)

  • Z15.06 for Genetic susceptibility to malignant neoplasm of digestive system

  • Use Z15.07 for Genetic susceptibility to malignant neoplasm of urinary tract

  • Use Z15.09 for Genetic susceptibility to other malignant neoplasm

  • Use Z15.1 for Genetic susceptibility to epilepsy and neurodevelopmental disorders

  • Use Z15.2 for Genetic susceptibility to obesity

  • Use Z15.3 for Genetic susceptibility to kidney disease

  • Z15.8 for Genetic susceptibility to other disease

  • Use Z15.81 for Genetic susceptibility to multiple endocrine neoplasia [MEN]

  • Use Z15.89 for Genetic susceptibility to other disease

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Includes

  • confirmed abnormal gene

Use Additional Code

  • code, if applicable, for any associated family history of the disease Z80 Z84

Type 1 Excludes

  • chromosomal anomalies Q90 Q99

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z15Overview

Is Z15 (Genetic susceptibility to disease) a billable code?

No. This is a category header that groups the codes for genetic susceptibility to disease, and headers cannot be submitted on claims. Claims for genetic susceptibility to disease need a more specific code from this category, such as Z15.01, Z15.02, and Z15.03.