ICD-10-CM Code Z15

Genetic susceptibility to disease

Version 2020 Non-Billable Code

Not Valid for Submission

Z15 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of genetic susceptibility to disease. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10:Z15
Short Description:Genetic susceptibility to disease
Long Description:Genetic susceptibility to disease

Consider the following ICD-10 codes with a higher level of specificity:

  • Z15.0 - Genetic susceptibility to malignant neoplasm
  • Z15.01 - Genetic susceptibility to malignant neoplasm of breast
  • Z15.02 - Genetic susceptibility to malignant neoplasm of ovary
  • Z15.03 - Genetic susceptibility to malignant neoplasm of prostate
  • Z15.04 - Genetic susceptibility to malignant neoplasm of endometrium
  • Z15.09 - Genetic susceptibility to other malignant neoplasm
  • Z15.8 - Genetic susceptibility to other disease
  • Z15.81 - Genetic susceptibility to multiple endocrine neoplasia [MEN]
  • Z15.89 - Genetic susceptibility to other disease

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code Z15:

Includes

Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
  • confirmed abnormal gene

Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
  • code, if applicable, for any associated family history of the disease Z80 Z84

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • chromosomal anomalies Q90 Q99

Code Classification

  • Factors influencing health status and contact with health services (Z00–Z99)
    • Genetic carrier and genetic susceptibility to disease (Z14-Z15)
      • Genetic susceptibility to disease (Z15)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Genetic Disorders

Genes are the building blocks of heredity. They are passed from parent to child. They hold DNA, the instructions for making proteins. Proteins do most of the work in cells. They move molecules from one place to another, build structures, break down toxins, and do many other maintenance jobs.

Sometimes there is a mutation, a change in a gene or genes. The mutation changes the gene's instructions for making a protein, so the protein does not work properly or is missing entirely. This can cause a medical condition called a genetic disorder.

You can inherit a gene mutation from one or both parents. A mutation can also happen during your lifetime.

There are three types of genetic disorders:

  • Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example.
  • Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. Chromosomes are the structures that hold our genes. Down syndrome is a chromosomal disorder.
  • Complex disorders, where there are mutations in two or more genes. Often your lifestyle and environment also play a role. Colon cancer is an example.

Genetic tests on blood and other tissue can identify genetic disorders.

NIH: National Library of Medicine


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