2027 ICD-10-CM Diagnosis Code Z15Genetic susceptibility to disease

ICD-10-CM Codes›Z00–Z99›Z14-Z15›Z15

ICD-10-CM Z15
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Z15 is a non-billable ICD-10-CM category code for genetic susceptibility to disease, so it cannot be submitted on claims. Use a more specific code from this category instead, such as Z15.01, Z15.02, Z15.03, and Z15.04.

Code Identity

ICD-10-CM Code
Z15
Billable Status
No — Non-Billable Category
Code Describes
Genetic susceptibility to disease
Short Description
Genetic susceptibility to disease
Same as the full description in the CMS dataset.
Chapter
Z14-Z15
Genetic carrier and genetic susceptibility to disease

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ14-Z15Genetic carrier and genetic susceptibility to disease
CategoryZ15Genetic susceptibility to disease
This CodeZ15Genetic susceptibility to disease

Specific Coding for Genetic susceptibility to diseaseOverview

Non-specific codes like Z15 require more characters. Use one of these billable codes instead:

  • Z15.0 for Genetic susceptibility to malignant neoplasm

  • Use Z15.01 for Genetic susceptibility to malignant neoplasm of breast

  • Use Z15.02 for Genetic susceptibility to malignant neoplasm of ovary

  • Use Z15.03 for Genetic susceptibility to malignant neoplasm of prostate

  • Use Z15.04 for Genetic susceptibility to malignant neoplasm of endometrium

  • Use Z15.05 for Genetic susceptibility to malignant neoplasm of fallopian tube(s)

  • Z15.06 for Genetic susceptibility to malignant neoplasm of digestive system

  • Use Z15.07 for Genetic susceptibility to malignant neoplasm of urinary tract

  • Use Z15.09 for Genetic susceptibility to other malignant neoplasm

  • Use Z15.1 for Genetic susceptibility to epilepsy and neurodevelopmental disorders

  • Use Z15.2 for Genetic susceptibility to obesity

  • Use Z15.3 for Genetic susceptibility to kidney disease

  • Z15.8 for Genetic susceptibility to other disease

  • Use Z15.81 for Genetic susceptibility to multiple endocrine neoplasia [MEN]

  • Use Z15.89 for Genetic susceptibility to other disease

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Z15: its own notes plus those printed at Chapter 21. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

  • confirmed abnormal gene

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

  • chromosomal anomalies (Q90-Q99)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Notes

General instructions on how these codes are used.

From Chapter 21 (Z00-Z99) Factors influencing health status and contact with health services applies to 1,425 codes
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
  • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
  • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Z15, its category, or a range that includes it.

Use Additional Code 1

These codes say to use an additional code from the note, and Z15 is one of the codes named.

  • Z40.0 Encounter for prophylactic surgery for risk factors related to malignant neoplasms
    code to identify risk factor, such as genetic susceptibility to malignant neoplasm Z15.-

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Z15Overview

What is the ICD-10 code for genetic susceptibility to disease?

Z15 is the ICD-10-CM category for genetic susceptibility to disease, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is Z15 (Genetic susceptibility to disease) a billable code?

No. This is a category header that groups the codes for genetic susceptibility to disease, and headers cannot be submitted on claims. Claims for genetic susceptibility to disease need a more specific code from this category, such as Z15.01, Z15.02, and Z15.03.

Does Z15 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code, if applicable, for any associated family history of the disease (Z80-Z84). The additional code is reported after Z15.