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  3. Z00–Z99
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  5. Estrogen, and other hormones and factors receptor status (Z17)

Estrogen, and other hormones and factors receptor status (Z17)

ICD-10 code Z17 covers the receptor status of estrogen, progesterone, and human epidermal growth factor 2 (HER2), which are key markers often assessed in cancers like breast cancer to guide treatment decisions.

This range includes codes that specify whether estrogen receptors are positive (Z17.0) or negative (Z17.1), with synonyms such as hormone receptor positive malignant neoplasm of breast and HER2-positive carcinoma. It also identifies progesterone receptor status, including positive (Z17.21) and negative (Z17.22). Human epidermal growth factor receptor 2 (HER2) status is similarly captured with positive (Z17.31) and negative (Z17.32) designations. Combined hormone receptor and HER2 statuses are detailed under Z17.4 with subcodes describing hormone receptor positive or negative paired with specific HER2 statuses, helping clinicians and coders precisely document receptor profiles critical for personalized cancer care and prognosis. This coding allows accurate representation of hormone and growth factor receptor testing results in patient records.

Instructional Notations

Code First

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.

  • malignant neoplasm, such as:
  • malignant neoplasm of breast C50
  • malignant neoplasm of ovary C56